Childhood maltreatment is associated with a sex‐dependent functional reorganization of a brain inhibitory control network
Open accessAbstract
Childhood adversity represents a major risk factor for drug addiction and other mental disorders. However, the specific mechanisms by which childhood adversity impacts human brain organization to confer greater vulnerability for negative outcomes in adulthood is largely unknown. As an impaired process in drug addiction, inhibitory control of behavior was investigated as a target of childhood maltreatment (abuse and neglect). Forty adults without Axis‐I psychiatric disorders (21 females) completed a Childhood Trauma Questionnaire (CTQ) and underwent functional MRI (fMRI) while performing a stop‐signal task. A group independent component analysis identified a putative brain inhibitory control network. Graph theoretical analyses and structural equation modeling investigated the impact of childhood maltreatment on the functional organization of this neural processing network. Graph theory outcomes revealed sex differences in the relationship between network functional connectivity and inhibitory control which were dependent on the severity of childhood maltreatment exposure. A network effective connectivity analysis indicated that a maltreatment dose‐related negative modulation of dorsal anterior cingulate (dACC) activity by the left inferior frontal cortex (IFC) predicted better response inhibition and lesser attention deficit hyperactivity disorder (ADHD) symptoms in females, but poorer response inhibition and greater ADHD symptoms in males. Less inhibition of the right IFC by dACC in males with higher CTQ scores improved inhibitory control ability. The childhood maltreatment‐related reorganization of a brain inhibitory control network provides sex‐dependent mechanisms by which childhood adversity may confer greater risk for drug use and related disorders and by which adaptive brain responses protect individuals from this risk factor. Hum Brain Mapp 35:1654–1667, 2014. © 2013 Wiley Periodicals, Inc.
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Recent neuroimaging studies show an impact of childhood trauma on resting-state functional brain connectivity.
“A few recent neuroimaging studies demonstrate an impact of CT on resting-state functional brain connectivity (17–20).”
From Impact of Childhood Trauma on Executive Function in Adolescence—Mediating Functional Brain Networks and Prediction of High-Risk Drinking (2020) · cites this paper as [18]
In adults, maltreatment-related changes in dorsal anterior cingulate cortex connectivity to inferior frontal cortex and precuneus have been linked to dysfunctional self-regulation and inhibitory control.
“in adults, maltreatment-related changes of functional connectivity of the dACC to cortical areas including the inferior frontal cortex and precuneus have been linked to dysfunctional self-regulation and inhibitory control (18,28).”
From Impact of Childhood Trauma on Executive Function in Adolescence—Mediating Functional Brain Networks and Prediction of High-Risk Drinking (2020) · cites this paper as [18]
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References 92 · Cited by 119
Research works printed but not linked: 3
- De Bellis MD Keshavan MS Clark DB Casey BJ Giedd JN Boring AM Frustaci K Ryan ND Developmental traumatology part II: brain development Biological Psychiatry 1999 45 10 1271 1284 10349033
- First MB Spitzer RL Gibbon M Williams JBW Structured Clinical Interview for DSM-IV-TR Axis I Disorders – Non-patient Edition (SCID-I/NP, 1/2007 revision 2007 New York, New York, USA Biometrics Research Department
- Green JG McLaughlin KA Berglund PA Gruber MJ Sampson NA Zaslavsky AM Kessler RC Childhood Adversities and Adult Psychiatric Disorders in the National Comorbidity Survey Replication I: Associations With First Onset of DSM-IV Disorders Arch Gen Psychiatry 2010 67 2 113 123 20124111 PMC2822662
- Authors
- Elton, A., Tripathi, S. P., Mletzko, T., Young, J., Cisler, J. M., James, G. A., & Kilts, C. D.
- Affiliations
- University of Arkansas for Medical Sciences (US)
- Emory University (US)
- Venue
- Human Brain Mapping
- Publisher
- Wiley
- Published
- 2013-04-24
- Volume
- 35
- Issue
- 4
- Pages
- 1654-1667
- ISSN
- 1065-9471 (ISSN-L)
- 1097-0193
- PMC
- PMC3779516
- OpenAlex
- W2100818092
- Cited by
- 119
- References
- 92
- Citations by year
- 2026: 4 · 2025: 7 · 2024: 9 · 2023: 3 · 2022: 5 · 2021: 9 · 2020: 9 · 2019: 14 · 2018: 12 · 2017: 14 · 2016: 17 · 2015: 5 · 2014: 8 · 2013: 3
- FWCI
- 12.22
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Human Brain Mapping (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institute on Drug Abuse (R01DA019999, T32DA022981)
- National Center for Research Resources (KL2RR029883, UL1RR029884)
- Topics
- Social Sciences › Psychology › Clinical Psychology › Child Abuse and Trauma
- Life Sciences › Neuroscience › Cognitive Neuroscience › Functional Brain Connectivity Studies
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
- Keywords
- child abuse, childhood adversity, inhibitory control, sex differences, response inhibition, ADHD symptoms, drug addiction risk, dorsal anterior cingulate cortex, inferior frontal cortex, functional connectivity, effective connectivity, brain network reorganization, stop-signal task
- MeSH terms
- Adult, Attention Deficit Disorder with Hyperactivity, Brain, Brain Mapping, Child, Child Abuse, Female, Humans, Impulsive Behavior, Inhibition, Psychological, Magnetic Resonance Imaging, Male, Neural Pathways, Neuropsychological Tests, Psychiatric Status Rating Scales, Psychomotor Performance, Surveys and Questionnaires, Sex Factors, Signal Processing, Computer-Assisted, Task Performance and Analysis, Executive Function
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