The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
p16 expression as a surrogate marker for HPV‐related oropharyngeal carcinoma: A guide for interpretative relevance and consistency
Abstract
Recent studies of oropharyngeal carcinoma have reported remarkable correlation between integrated human papillomavirus (HPV) viral detection and p16 protein overexpression in tumor cells. These findings led to calls for the substitution of p16 expression for the more demanding HPV testing in clinical practice. The rationale for such practice is largely driven by the simplicity, low cost, and the feasibility of the immunohistochemical (IHC) analysis. There are, however, several caveats that need to be fully considered. These include the subjective nature of IHC evaluation, the variable mechanisms of p16 expression in head and neck squamous cell carcinoma, and the lack of scoring and interpretive criteria. This perspective addresses the conceptual and practical issues associated with the p16 expression analysis and provides a broad outline for its application and evaluation in patients with oropharyngeal carcinoma. © 2011 Wiley Periodicals, Inc. Head Neck, 2012
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Cites
The Regulation of INK4/ARF in Cancer and Aging
Kim, W. Y., & Sharpless, N. E. (2006) · Cell · doi:10.1016/j.cell.2006.10.003 · Cited by 1,009 · cited 1×
“factor, and, in turn, prevents cell-cycle progression.(15) In conventional HNSCC, the p16 tumor suppressor gene is inactivated primarily by various genetic and nongenetic (eg, promoter hypermethylation) modifications such that the expression of its protein product is lost, diminished, or limited to tumor nuclei.”
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Cited by
Lydiatt, W. M., Patel, S. G., O'Sullivan, B., Brandwein, M. S., Ridge, J. A., Migliacci, J. C., Loomis, A. M., & Shah, J. P. (2017) · CA: A Cancer Journal for Clinicians · doi:10.3322/caac.21389 · Cited by 1,625
Human Papillomavirus-related Carcinomas of the Sinonasal Tract
Bishop, J. A., Guo, T. W., Smith, D. F., Wang, H., Ogawa, T., Pai, S. I., & Westra, W. H. (2013) · American Journal of Surgical Pathology · doi:10.1097/pas.0b013e3182698673 · Cited by 298
Self-citationGillison, M. L., Alemany, L., Snijders, P. J. F., Chaturvedi, A., Steinberg, B. M., Schwartz, S., & Castellsagué, X. (2012) · Vaccine · doi:10.1016/j.vaccine.2012.05.070 · Cited by 289
Metadata
- Authors
- El‐Naggar, A. K., & Westra, W. H.
- Venue
- Head & Neck
- Publisher
- Wiley
- Published
- 2011-12-16
- Volume
- 34
- Issue
- 4
- Pages
- 459-461
- ISSN
- 1043-3074 (ISSN-L)
- 1097-0347
- OpenAlex
- W1968108709
- Cited by
- 313
- References
- 1
- FWCI
- 19.11
- Type
- journal article
- Language
- en
- Open access
- closed
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- El‐Naggar, A. K., & Westra, W. H. (2012). p16 expression as a surrogate marker for HPV‐related oropharyngeal carcinoma: A guide for interpretative relevance and consistency. Head & Neck. https://doi.org/10.1002/hed.21974
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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