The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Altered Thiol and Calcium Homeostasis in Oxidative Hepatocellular Injury
Open accessAbstract
Perturbation of cellular thiol homeostasis occurs during the early phase of oxidative cell injury in isolated hepatocytes.This perturbation, involves depletion of soluble and protein-bound thiols, and is associated with altered intracellular calcium (Ca") homeostasis resulting from inhibition of major Ca2+ transport systems.The result is sustained increase in cytosolic Ca2+ concentration which appears to trigger cytotoxicity.The step-wise reduction of molecular oxygen to water results in formation of several, potentially toxic, intermediates, including superoxide anion-free radical, hydrogen peroxide and the hydroxyl radical: O2 + ee 0; 0; + e-+ 2H' + H202 H202 + e-+ H' e OH. + H20 OH. + e-+ H' + H20
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Cites
Moore, M., Thor, H., Moore, G., Nelson, S., Moldéus, P., & Orrenius, S. (1985) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(17)38834-8 · Cited by 410
Self-citation
Cited by
Jaeschke, H., McGill, M. R., & Ramachandran, A. (2012) · Drug Metabolism Reviews · doi:10.3109/03602532.2011.602688 · Cited by 964
Molecular and Cellular Aspects of Thiol–Disulfide Exchange
Gilbert, H. F. (1990) · Advances in Enzymology - and Related Areas of Molecular Biology · doi:10.1002/9780470123096.ch2 · Cited by 758
Effect of chronic intake of arsenic-contaminated water on liver
Guha Mazumder, D. N. (2005) · Toxicology and Applied Pharmacology · doi:10.1016/j.taap.2004.08.025 · Cited by 299
Tirmenstein, M. A., & Nelson, S. D. (1989) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)81731-8 · Cited by 298
The pathophysiological significance of lipid peroxidation in oxidative cell injury
Tribble, D. L., Aw, T. Y., & Jones, D. P. (1987) · Hepatology · doi:10.1002/hep.1840070227 · Cited by 290
Metadata
- Authors
- Bellomo, G., & Orrenius, S.
- Venue
- Hepatology
- Published
- 1985-09
- Volume
- 5
- Issue
- 5
- Pages
- 876-882
- ISSN
- 0270-9139 (ISSN-L)
- OpenAlex
- W2061052410
- Cited by
- 246
- References
- 1
- FWCI
- 5.69
- Type
- journal article
- Language
- en
- Open access
- bronze
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
