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Multivariate analysis of prognostic factors in fulminant hepatitis B
Abstract
We assessed prognostic factors in 115 patients with serologically defined fulminant hepatitis B. The diagnosis in each case was based on the finding of IgM antibody to the hepatitis B core antigen in serum. Multivariate analysis showed that factor V level (p < 0.001), patient's age (p = 0.001), absence of detectable HBsAg by radioimmunoassay (p = 0.06) and serum α-fetoprotein concentration (p = 0.07) were independent predictors of survival. The survival rate in the 21 patients in whom HBsAg was not detected was 47%, which was significantly higher than the survival rate of 17% observed in the 94 HBsAg-positive patients (p = 0.006). In patients with fulminant hepatitis B, the absence of HBsAg in serum as detected by radioimmunoassay has an independent, favorable prognostic value.
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Cited by
Early indicators of prognosis in fulminant hepatic failure
O'Grady, J. G., Alexander, G. J. M., Hayllar, K. M., & Williams, R. (1989) · Gastroenterology · doi:10.1016/0016-5085(89)90081-4 · Cited by 2,085
Martin, P., DiMartini, A., Feng, S., Brown, R., & Fallon, M. (2014) · Hepatology · doi:10.1002/hep.26972 · Cited by 1,045
EASL Clinical Practical Guidelines on the management of acute (fulminant) liver failure
Wendon, J., Cordoba, J., Dhawan, A., Larsen, F. S., Manns, M., Nevens, F., Samuel, D., Simpson, K. J., Yaron, I., & Bernardi, M. (2017) · Journal of Hepatology · doi:10.1016/j.jhep.2016.12.003 · Cited by 917
Stravitz, R. T., & Lee, W. M. (2019) · The Lancet · doi:10.1016/s0140-6736(19)31894-x · Cited by 844
Timing and benefit of liver transplantation in acute liver failure
O’Grady, J. (2014) · Journal of Hepatology · doi:10.1016/j.jhep.2013.10.024 · Cited by 130
Metadata
- Authors
- Bernuau, J., Goudeau, A., Poynard, T., Dubois, F., Lesage, G., Yvonnet, B., Degott, C., Bezeaud, A., Rueff, B., & Benhamou, J.-P.
- Venue
- Hepatology
- Published
- 1986-07
- Volume
- 6
- Issue
- 4
- Pages
- 648-651
- ISSN
- 0270-9139 (ISSN-L)
- OpenAlex
- W2158736090
- Cited by
- 501
- References
- 0
- FWCI
- 5.44
- Type
- journal article
- Language
- en
- Open access
- closed
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- Bernuau, J., Goudeau, A., Poynard, T., Dubois, F., Lesage, G., Yvonnet, B., Degott, C., Bezeaud, A., Rueff, B., & Benhamou, J.-P. (1986). Multivariate analysis of prognostic factors in fulminant hepatitis B. Hepatology. https://doi.org/10.1002/hep.1840060417
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