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Cited by 53

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Dietary N–3 Polyunsaturated Fatty Acids Decrease Biliary Cholesterol Saturation in Gallstone Disease

Berr, Frieder, Holl, Joseph, Jüngst, Dieter, Fischer, Sven, Richter, Werner O., Seifferth, Bernd, Paumgartner, Gustav·1992·Hepatology
DOI 10.1002/hep.1840160418
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Abstract

Because fatty acid composition of biliary phospholipids influences cholesterol secretion into bile, we investigated whether replacement of n–1 monounsaturated or n–6 polyunsaturated fatty acids with n–3 polyunsaturated fatty acids in biliary phosphatidylcholines reduces supersaturation with cholesterol and prevents precipitation of cholesterol crystals in bile of gallstone patients. Seven patients with radiolucent gallstones in functioning gallbladders were studied before (control) and after 5 wk of dietary supplementation with marine fish oil (11.3 gm/day = 3.75 gm n–3 polyunsaturated fatty acids/day). Duodenal bile was collected for analysis during intravenous infusion of cholecystokinin. Gallbladder emptying in response to cholecystokinin was comparable before and during intake of n–3 polyunsaturated fatty acids. Intake of n–3 polyunsaturated fatty acids increased (p < 0.001) the fractions of eicosapentaenoic and docosahexaenoic acids and decreased the fractions of linoleic (p < 0.001) and arachidonic acids (p < 0.02) in biliary phospholipids. Concomitantly, the molar ratio of cholesterol to phospholipids decreased (-19%; p < 0.05). As a consequence, the cholesterol saturation index was reduced by -25% (p = 0.01), from 1.60 ± 0.44 to 1.24 ± 0.38. However, in vitro nucleation time of duodenal bile was not prolonged. The decrease in cholesterol saturation was not sufficient to prevent nucleation of cholesterol crystals in bile of gallstone patients. In conclusion, our data suggest that cholesterol saturation can be influenced by the fatty acid composition of the phosphatidylcholines secreted in bile. (HEPATOLOGY 1992;16:960-967.)

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  • Legumes, olive oil, and nuts are reported to reduce the risk of cholecystectomy.

    “Other foods reported to reduce the risk of cholecystectomy include legumes, olive oil [68], and nuts [69].”

    From Excess Body Weight and Gallstone Disease (2021) · cites this paper as [68]

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Metadata

Authors
Berr, F., Holl, J., Jüngst, D., Fischer, S., Richter, W. O., Seifferth, B., & Paumgartner, G.
Venue
Hepatology
Publisher
Ovid Technologies (Wolters Kluwer Health)
Published
1992-10
Volume
16
Issue
4
Pages
960-967
ISSN
0270-9139
DOI
10.1002/hep.1840160418
Cited by
53
References
0
Language
en
Licence
doi.wiley.com/10.1002/tdm_license_1.1 (tdm, 8370 d)

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