The DOI matches its Crossref record; 12 of the 12 references it cites were found in a registry or an index.
Hepatic and portal vein thrombosis in cirrhosis: Possible role in development of parenchymal extinction and portal hypertension
Open accessAbstract
Obliterative lesions in portal veins (PVs) and hepatic veins (HVs) of all sizes are known to occur in cirrhotic livers. PV lesions have generally been attributed to thrombosis, but the pathogenesis of the HV (veno-occlusive) lesions is unknown. We have studied 61 cirrhotic livers removed at transplantation to clarify the prevalence, distribution, and pathogenesis of venous lesions, as well as the association of these lesions with other morphological features and clinical morbidity. Intimal fibrosis that is highly suggestive of healed HV or PV thrombosis was found in at least 70% and 36% of livers, respectively. The distribution of HV lesions was patchy and largely confined to veins between 0.1 and 3 mm in diameter, suggesting multifocal origin in small veins. PV lesions were more uniform throughout the liver, suggesting origin in large veins with propagation to the small veins. HV lesions were associated with regions of confluent fibrosis (focal parenchymal extinction), and PV lesions were associated with regional variation in the size of cirrhotic nodules and a history of bleeding varices. These observations suggest that thrombosis of medium and large PVs and HVs is a frequent occurrence in cirrhosis, and that these events are important in causing progression of cirrhosis.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
(1965) · Elsevier eBooks · doi:10.1016/c2013-0-06663-7 · Cited by 664
Incidence of portal vein thrombosis in liver cirrhosis
Okuda, K., Ohnishi, K., Kimura, K., Matsutani, S., Sumida, M., Goto, N., Musha, H., Takashi, M., Suzuki, N., Shinagawa, T., et al. (1985) · Gastroenterology · doi:10.1016/0016-5085(85)90327-0 · Cited by 387
Harbin, W. P., Robert, N. J., & Ferrucci, J. T. (1980) · Radiology · doi:10.1148/radiology.135.2.7367613 · Cited by 328
Prevalence of spontaneous hepatofugal portal flow in liver cirrhosis
Gaiani, S., Bolondi, L., Li Bassi, S., Zironi, G., Siringo, S., & Barbara, L. (1991) · Gastroenterology · doi:10.1016/0016-5085(91)90596-d · Cited by 193
Role of thrombosis in the pathogenesis of congestive hepatic fibrosis (cardiac cirrhosis)
Wanless, I. R., Liu, J. J., & Butany, J. (1995) · Hepatology · doi:10.1002/hep.1840210504 · Cited by 179
Self-citationInjection-corrosion studies of normal and cirrhotic livers.
Hales, M. R., Allan, J. S., & Hall, E. M. (1998) · PubMed · Cited by 150
Portal Thrombosis in Cirrhotics
Belli, L., Sansalone, C. V., Aseni, P., Romani, F., & Rondinara, G. F. (1986) · Annals of Surgery · doi:10.1097/00000658-198603000-00012 · Cited by 121
Wanless, I. R., Lentz, J., & Roberts, E. A. (1985) · PubMed · Cited by 82
Self-citationPortal hypertension in primary biliary cirrhosis.
Kew, M. C., Varma, R. R., Santos, H. D., & Scheuer, P. J. (1971) · PubMed · Cited by 75
Portal hypertension in primary biliary cirrhosis
Kew, M. C., Varma, R. R., Santos, H. A. D., & Scheuer, P. J. (1971) · Gut · doi:10.1136/gut.12.10.830 · Cited by 73
Cited by
Mechanisms of fibrosis: therapeutic translation for fibrotic disease
Wynn, T. A., & Ramalingam, T. R. (2012) · Nature Medicine · doi:10.1038/nm.2807 · Cited by 3,541
Sarin, S. K., Kedarisetty, C. K., Abbas, Z., Amarapurkar, D., Bihari, C., Chan, A. C. Y., Chawla, Y. K., Dokmeci, A. K., Garg, H., Ghazinyan, H., et al. (2014) · Hepatology International · doi:10.1007/s12072-014-9580-2 · Cited by 1,481
Rebalanced hemostasis in patients with liver disease: evidence and clinical consequences
Lisman, T., & Porte, R. J. (2010) · Blood · doi:10.1182/blood-2010-02-261891 · Cited by 667
Coagulation in liver disease: A guide for the clinician
Northup, P. G., & Caldwell, S. H. (2013) · Clinical Gastroenterology and Hepatology · doi:10.1016/j.cgh.2013.02.026 · Cited by 268
Pathologic Features and Evolution of Primary Biliary Cirrhosis and Primary Sclerosing Cholangitis
Scheuer, P. J. (1998) · Mayo Clinic Proceedings · doi:10.1016/s0025-6196(11)63652-5 · Cited by 106
Metadata
- Authors
- Wanless, I. R., Wong, F., Blendis, L. M., Greig, P., Heathcote, J. E., & Levy, G.
- Venue
- Hepatology
- Published
- 1995-05
- Volume
- 21
- Issue
- 5
- Pages
- 1238-1247
- ISSN
- 0270-9139 (ISSN-L)
- OpenAlex
- W1968641413
- Cited by
- 434
- References
- 12
- FWCI
- 3.18
- Type
- journal article
- Language
- en
- Open access
- bronze
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
How to cite
Cite CoChat for the checks on this page, and the paper for its own findings.
- This page
- CoChat. (2026). Citation check: Hepatic and portal vein thrombosis in cirrhosis: Possible role in development of parenchymal extinction and portal hypertension. https://app.cochat.ai/papers/10.1002/hep.1840210505
- The paper
- Wanless, I. R., Wong, F., Blendis, L. M., Greig, P., Heathcote, J. E., & Levy, G. (1995). Hepatic and portal vein thrombosis in cirrhosis: Possible role in development of parenchymal extinction and portal hypertension. Hepatology. https://doi.org/10.1002/hep.1840210505
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
