Tauroursodeoxycholic acid protects rat hepatocytes from bile acid–induced apoptosis via activation of survival pathways

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1. Sphingosine kinase-1 inhibition protects primary rat hepatocytes against bile salt-induced apoptosis
   Golnar Karimian, Manon Buist‐Homan, Martina Schmidt, Uwe J.F. Tietge, Jan Freark de Boer, Karin Klappe, Jan Kok, Laurent Combettes, Thierry Tordjmann, Klaas Nico Faber et al. · 2013 · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease
2. Eupatilin attenuates bile acid-induced hepatocyte apoptosis
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3. An Update on Adverse Outcome Pathways Leading to Liver Injury
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4. Intracellular Signaling by Bile Acids
   M. S. Anwer · 2014 · Journal of Bio-Science
5. Unconjugated Bile Salts Shuttle Through Hepatocyte Peroxisomes for Taurine Conjugation
   Krzysztof P. Rembacz, Jannes Woudenberg, Mark Hoekstra, Elles Jonkers, Fiona A.J. van den Heuvel, Manon Buist‐Homan, Titia E. Woudenberg-Vrenken, Jana Roháčová, Maria Luisa Marin, Miguel Angel Miranda et al. · 2010 · Hepatology
6. Tauroursodeoxycholic acid reduces bile acid-induced apoptosis by modulation of AP-1
   Thomas Pusl, Timo Vennegeerts, Ralf Wimmer, Gerald Denk, Ulrich H. Beuers, Christian Rust · 2007 · Biochemical and Biophysical Research Communications
7. Combination of tauroursodeoxycholic acid and N‐acetylcysteine exceeds standard treatment for acetaminophen intoxication
   Annelies Paridaens, Sarah Raevens, Isabelle O. Colle, Eliene Bogaerts, Yves‐Paul Vandewynckel, Xavier Verhelst, Anne Hoorens, Leo A. van Grunsven, Hans Van Vlierberghe, Anja M. Geerts et al. · 2016 · Liver International
8. Tauroursodeoxycholate Protects Rat Hepatocytes from Bile Acid-Induced Apoptosis via β1-Integrin- and Protein Kinase A-Dependent Mechanisms
   Annika Sommerfeld, Roland Reinehr, Dieter Häussinger · 2015 · Cellular Physiology and Biochemistry
9. Na+/H+ exchanger regulatory factor 1 knockout mice have an attenuated hepatic inflammatory response and are protected from cholestatic liver injury
   Man Li, Albert Mennone, Carol J. Soroka, Lee R. Hagey, Xinshou Ouyang, Edward J. Weinman, James Lorenzen Boyer · 2015 · Hepatology
10. Treatment with Taurine Attenuates Hepatic Apoptosis in NZB/W F1 Mice Fed with a High-Cholesterol Diet
    Hsu, Tsai-Ching, Chiang, Szu-Yi, Wu, Jen-Huang, Tsai, Chun-Chou, Huang, Chih-Yang, Chen, Yi-Chen, Tzang, Bor-Show · 2008 · Journal of Agricultural and Food Chemistry
11. UDCA for Drug-Induced Liver Disease: Clinical and Pathophysiological Basis
    Fernando Bessone, Geraldine L. Hillotte, Natalia Ahumada, Fernanda Jaureguizahar, Anabela Carolina Medeot, Marcelo G. Roma · 2024 · Seminars in Liver Disease
12. Current Landscape and Evolving Therapies for Primary Biliary Cholangitis
    Stefano Fiorucci, Ginevra Urbani, Cristina Di Giorgio, Michele Biagioli, Eleonora Distrutti · 2024 · Cells
13. Medical Treatment of Primary Biliary Cirrhosis and Primary Sclerosing Cholangitis
    Christian Rust, Ulrich H. Beuers · 2005 · Clinical Reviews in Allergy & Immunology
14. cAMP-GEF cytoprotection by Src tyrosine kinase activation of phosphoinositide-3-kinase p110 β/α in rat hepatocytes
    Anna Gates, Simon D. Hohenester, M. Sawkat Anwer, Cynthia R. L. Webster · 2009 · American Journal of Physiology-Gastrointestinal and Liver Physiology
15. The bile acid TUDCA reduces age-related hyperinsulinemia in mice
    Lucas Zangerolamo, Marina Uchôa Wall Barbosa De Carvalho, Letícia Barssotti, Gabriela Moreira Soares, Carine Marmentini, Antonio Carlos Boschero, Helena C.L. Barbosa · 2022 · Scientific Reports
16. Ursodeoxycholic acid-induced inhibition of DLC1 protein degradation leads to suppression of hepatocellular carcinoma cell growth
    Jung‐Hwan Yoon · 2011 · Oncology Reports
17. Hydrophobic bile acid apoptosis is regulated by sphingosine-1-phosphate receptor 2 in rat hepatocytes and human hepatocellular carcinoma cells
    Cynthia R. L. Webster, M. S. Anwer · 2016 · American Journal of Physiology-Gastrointestinal and Liver Physiology
18. Bile acids alter the subcellular localization of CNT2 (concentrative nucleoside cotransporter) and increase CNT2-related transport activity in liver parenchymal cells
    Sonia Fernández‐Veledo, Isabel Huber‐Ruano, Ivette Aymerich, Sylvie Duflot, Francisco Javier Casado, Marçal Pastor‐Anglada · 2006 · Biochemical Journal
19. Adverse Outcome Pathways as Tools to Assess Drug-Induced Toxicity
    Mathieu Vinken · 2016 · Methods in molecular biology
20. The active metabolite of leflunomide, A77 1726, protects rat hepatocytes against bile acid-induced apoptosis
    Titia E. Vrenken, Manon Buist‐Homan, Allard Jan Kalsbeek, Klaas Nico Faber, Han J. Moshage · 2008 · Journal of Hepatology
21. On the Role of Illness Duration and Nutrient Restriction in Cholestatic Alterations that Occur During Critical Illness
    Marc Jenniskens, Fabián Güiza, Marlies Oorts, Sarah Vander Perre, Sarah Derde, Thomas Dufour, Steven Thiessen, Pieter Annaert, Greet Van den Berghe, Lies Langouche · 2017 · Shock
22. cAMP-guanine exchange factor protection from bile acid-induced hepatocyte apoptosis involves glycogen synthase kinase regulation of c-Jun NH2-terminal kinase
    Andrea N. Johnston, Kathleen Marie Ponzetti, M. S. Anwer, Cynthia R. L. Webster · 2011 · American Journal of Physiology-Gastrointestinal and Liver Physiology
23. Endoplasmic reticulum stress and pulmonary hypertension
    Hu, Yanan, Yang, Wenhao, Xie, Liang, Liu, Tao, Liu, Hanmin, Liu, Bin · 2020 · Pulmonary Circulation
24. Glycocholic acid aggravates liver fibrosis by promoting the up-regulation of connective tissue growth factor in hepatocytes
    Zihang Yuan, Jie Wang, Haoran Zhang, Yuanyuan Chai, Yunxia Xu, Yingying Miao, Ziqiao Yuan, Luyong Zhang, Zhenzhou Jiang, Qinwei Yu · 2022 · Cellular Signalling
25. Anti-oxidants do not prevent bile acid-induced cell death in rat hepatocytes
    Titia E. Woudenberg-Vrenken, Manon Buist‐Homan, Laura Conde de la Rosa, Klaas Nico Faber, Han J. Moshage · 2010 · Liver International
26. Plasma levels of ursodeoxycholic acid in black bears, Ursus americanus: Seasonal changes
    Susana Solá, David L. Garshelis, Joana D. Amaral, Karen V. Noyce, Pamela L. Coy, Clifford J. Steer, Paul A. Iaizzo, Cecília M. P. Rodrigues · 2006 · Comparative Biochemistry and Physiology Part C Toxicology & Pharmacology
27. Chemical modifications of bile acids under high-intensity ultrasound or microwave irradiation
    Giancarlo Cravotto, Luisa Boffa, Marta Turello, Massimo Parenti, Alessandro Barge · 2004 · Steroids
28. Bile Acid Toxicity and Protein Kinases
    Atilla Engin · 2021 · Advances in experimental medicine and biology
29. Cholangiocyte death in ductopenic cholestatic cholangiopathies: Mechanistic basis and emerging therapeutic strategies
    Soraya Salas‐Silva, Arturo Simoni Nieves, Jocelyn López-Ramirez, Leticia Bucio, Luis Enrique Gómez-Quiroz, María Concepción Gutiérrez‐Ruíz, Marcelo G. Roma · 2019 · Life Sciences
30. Hepatitis C virus core or NS3/4A protein expression preconditions hepatocytes against oxidative stress and endoplasmic reticulum stress
    W. Alfredo Ríos‐Ocampo, Toos Daemen, Manon Buist‐Homan, Klaas Nico Faber, María Cristina Navas, Han J. Moshage · 2019 · Redox Report
31. Prevention of Clostridium sordellii Lethal Toxin-Induced Apoptotic Cell Death by Tauroursodeoxycholic Acid
    Florian Schulz, Ingo Just, Harald Genth · 2009 · Biochemistry
32. UPLC-MS-based serum metabonomics for identifying acute liver injury biomarkers in Chinese miniature pigs
    Jing Ma, Jiong Yu, Xiaoru Su, Chengxing Zhu, Xiao Yang, Huawang Sun, Deying Chen, Ying Wang, Hongcui Cao, Jianxin Lu · 2014 · Toxicology Letters
33. A novel, protective role of ursodeoxycholate in bile-induced pancreatic ductal injury
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34. Hormesis in Cholestatic Liver Disease; Preconditioning with Low Bile Acid Concentrations Protects against Bile Acid-Induced Toxicity
    Esther M. Verhaag, Manon Buist‐Homan, Martijn Koehorst, Albert Kornelis Groen, Han J. Moshage, Klaas Nico Faber · 2016 · PLoS ONE
35. Ursodeoxycholic Acid Protects Colon Cancer HCT116 Cells From Deoxycholic Acid-Induced Apoptosis by Inhibiting Apoptosome Formation
    Tohru SAEKI, Satoko Yui, Tadashi Hirai, Takami Fujii, Sawami Okada, Ryuhei Kanamoto · 2012 · Nutrition and Cancer
36. Role of Mitochondria in Drug-Induced Cholestatic Injury
    George E.N. Kass, Shirley C. Price · 2008 · Clinics in Liver Disease
37. Effects of bile acids on expression of the human apical sodium dependent bile acid transporter gene
    William C. Duane, Wendy Xiong, Jennifer J. Wolvers · 2007 · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids
38. Primary biliary cirrhosis: From bench to bedside
    Elias Kouroumalis · 2015 · World Journal of Gastrointestinal Pharmacology and Therapeutics
39. Osmotic Stress Induced Cell Death in Wheat Is Alleviated by Tauroursodeoxycholic Acid and Involves Endoplasmic Reticulum Stress–Related Gene Expression
    Liting Zhang, Zeyu Xin, Xing Yu, Chao Ma, Weiwei Liang, Meichen Zhu, Qiwei Cheng, Zongzhen Li, Yanan Niu, Yongzhe Ren et al. · 2017 · Frontiers in Plant Science
40. Bile Acid Supplementation Improves Murine Pancreatitis in Association With the Gut Microbiota
    Youdong Wan, Ruixue Zhu, Xinting Pan, Tongwen Sun · 2020 · Frontiers in Physiology
41. Restoration of articular osteochondral defects in rat by a bi-layered hyaluronic acid hydrogel plug with TUDCA-PLGA microsphere
    Byoung‐Ju Kim, Yoshie Arai, Bogyu Choi, Sunghyun Park, Jinsung Ahn, Inbo Han, Soo‐Hong Lee · 2017 · Journal of Industrial and Engineering Chemistry
42. The effect of ω-3 polyunsaturated fatty acids on the liver lipidome, proteome and bile acid profile: parenteral versus enteral administration
    Kamila Bechyňská, Nikola Ďásková, Nikola Vrzáčková, Karel Harant, Marie Heczková, Kateřina Podzimkova, Miriam Brátová, Helena Daňková, Zuzana Berková, Vít Kosek et al. · 2019 · Scientific Reports
43. Eicosapentaenoic Acid and Docosahexaenoic Acid Synergistically Attenuate Bile Acid–Induced Hepatocellular Apoptosis
    Emma M. Tillman, Richard A. Helms, Dennis D. Black · 2011 · Journal of Parenteral and Enteral Nutrition
44. The effect of tauroursodeoxycholic Acid (TUDCA) treatment on placental endoplasmic reticulum (ER) stress in a rat model of advanced maternal age
    Mazhar Pasha, Raven D. Kirschenman, Amy L. Wooldridge, Floor Spaans, Christy‐Lynn M. Cooke, Sandra Thomas Davidge · 2023 · PLoS ONE
45. Protective effects of caffeine against palmitate-induced lipid toxicity in primary rat hepatocytes is associated with modulation of adenosine receptor A1 signaling
    Johanna C. Arroyave-Ospina, Manon Buist‐Homan, Martina Schmidt, Han J. Moshage · 2023 · Biomedicine & Pharmacotherapy
46. From Alcohol Toxicity to Treatment
    Helmut Karl Seitz, Mikko P. Salaspuro, Markku J. Savolainen, Paul Haber, Hiromasa Ishii, Rolf Teschke, Han J. Moshage, Charles S. Lieber · 2005 · Alcoholism Clinical and Experimental Research
47. Cyclic AMP stimulates Mrp2 translocation by activating p38α MAPK in hepatic cells
    Christopher M. Schonhoff, Cynthia R. L. Webster, M. Sawkat Anwer · 2010 · American Journal of Physiology-Gastrointestinal and Liver Physiology
48. Activation of CREB by tauroursodeoxycholic acid protects cholangiocytes from apoptosis induced by mTOR inhibition†
    Lifu Wang, Anne‐Christine Piguet, Karin Schmidt, Thierry Tordjmann, Jean‐François Dufour · 2005 · Hepatology
49. FDX1-mediated cuproptosis promotes cholestatic liver injury exacerbated by taurocholic acid-enhanced copper accumulation
    Yujun Guo, Min Yang, Sun Sb, Zhaohua Zhong, Wenjun Lu, Ze'nan Zhang, Meili Fan, Aodan Zhang, Tingting Zhang, Yang Wu et al. · 2026 · Cell Death Discovery
50. Obeticholic acid improved triptolide/lipopolysaccharide‐induced hepatotoxicity by inhibiting caspase‐11‐GSDMD pyroptosis pathway
    Peishi Liang, Shaoyun Zhou, Ziqiao Yuan, Luyong Zhang, Zhenzhou Jiang, Qinwei Yu · 2022 · Journal of Applied Toxicology
51. EGFR participates downstream of ERα in estradiol-17β-d-glucuronide-induced impairment of Abcc2 function in isolated rat hepatocyte couplets
    Ismael Ricardo Barosso, Andres Ernesto Zucchetti, Gisel Sabrina Miszczuk, Andrea Carolina Boaglio, Diego R. Taborda, Marcelo G. Roma, Fernando Ariel Crocenzi, Enrique Juan Sánchez Pozzi · 2015 · Archives of Toxicology
52. Bile Acid-Induced Liver Injury in Cholestasis
    Tiangang Li, John Y.L. Chiang · 2017 · Springer eBooks
53. Bile Acids as Signaling Molecules: Role of Ursodeoxycholic Acid in Cholestatic Liver Disease
    Eduardo Cifuentes-Silva, Claudio Cabello‐Verrugio · 2023 · Current Protein and Peptide Science
54. Hemochromatosis: As a conformational disorder
    Steven G. Gray, John Crowe, Matthew W. Lawless · 2009 · The International Journal of Biochemistry & Cell Biology
55. Taurolithocholic Acid-3 Sulfate Impairs Insulin Signaling in Cultured Rat Hepatocytes and Perfused Rat Liver
    Gudrun Mannack, Dirk Graf, Markus M. Donner, Lisa Richter, Boris Görg, Stephan vom Dahl, Dieter Häussinger, Freimut Schliess · 2008 · Cellular Physiology and Biochemistry
56. Protein kinase Cδ protects against bile acid apoptosis by suppressing proapoptotic JNK and BIM pathways in human and rat hepatocytes
    Cynthia R. L. Webster, Andrea N. Johnston, M. S. Anwer · 2014 · American Journal of Physiology-Gastrointestinal and Liver Physiology
57. Review article: insights into the bile acid‐gut microbiota axis in intestinal failure‐associated liver disease—redefining the treatment approach
    Yaoxuan Wang, Lei Zheng, Zhiyuan Zhou, Danhua Yao, Yuhua Huang, Bin Liu, Yantao Duan, Yousheng Li · 2021 · Alimentary Pharmacology & Therapeutics
58. Pertussis Toxin, an Inhibitor of Gαi PCR, Inhibits Bile Acid- and Cytokine-Induced Apoptosis in Primary Rat Hepatocytes
    Golnar Karimian, Manon Buist‐Homan, Klaas Nico Faber, Han J. Moshage · 2012 · PLoS ONE
59. Elevated cholesterol levels have a poor prognosis in a cholestasis scenario
    Natalia Nuño‐Lámbarri, Varenka J. Barbero-Becerra, Misael Uribe, Norberto Carlos Chávez-Tapia · 2016 · Journal of Biochemical and Molecular Toxicology
60. Regio- and stereoselective reductions of dehydrocholic acid
    Giancarlo Cravotto, Arianna E. Binello, Luisa Boffa, Ornelio Rosati, Marco Boccalini, Stefano Chimichi · 2006 · Steroids
61. Activation of focal adhesion kinase and JNK contributes to the extracellular matrix and cAMP-GEF mediated survival from bile acid induced apoptosis in rat hepatocytes
    Paul Usechak, Anna Gates, Cynthia R. L. Webster · 2008 · Journal of Hepatology
62. Angiotensin II Protects Primary Rat Hepatocytes against Bile Salt-Induced Apoptosis
    Golnar Karimian, Manon Buist‐Homan, Bojana Mikus, Robert H. Henning, Klaas Nico Faber, Han J. Moshage · 2012 · PLoS ONE
63. p38 MAPK α and β isoforms differentially regulate plasma membrane localization of MRP2
    Christopher M. Schonhoff, Se Won Park, Cynthia R. L. Webster, M. Sawkat Anwer · 2016 · American Journal of Physiology-Gastrointestinal and Liver Physiology
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    Ling Xiong, Ya-Xin Huang, Lan Mao, Yong Xu, Yongqiong Deng · 2025 · World Journal of Diabetes
65. Taurochenodeoxycholate relaxes rat mesenteric arteries through activating eNOS: Comparing with glycochenodeoxycholate and tauroursodeoxycholate
    Changlin Zhen, Jie Yan, Yu Zhao, Shanliang Li, Mingyu Liu, Xin Shen, Na Li, Yonghui Zhang, Yanqiu Zhang, Chun-Yan Ma et al. · 2016 · European Journal of Pharmacology
66. A fluorescent analogue of tauroursodeoxycholic acid reduces ER stress and is cytoprotective
    Jason Gavin, Fran Quilty, Ferenc Májer, Georgina Gilsenan, Anne-Marie Byrne, Aideen Long, Gábor Radics, John F. Gilmer · 2016 · Bioorganic & Medicinal Chemistry Letters
67. Combination of Plasma-Based Metabolomics and Machine Learning Algorithm Provides a Novel Diagnostic Strategy for Malignant Mesothelioma
    Na Li, Chenxi Yang, Sicheng Zhou, Siyu Song, Yuyao Jin, Ding Wang, Junping Liu, Yun Liang Gao, Haining Yang, Weimin Mao et al. · 2021 · Diagnostics
68. Insight into Nephrotoxicity and Processing Mechanism of Arisaema erubescens (Wall.) Schott by Metabolomics and Network Analysis
    Min Wang, Na Yang, Xu Wu, Ting Zou, Jiahui Zheng, Huaijun Zhu, Chongbo Zhao, Jing Wang · 2023 · Drug Design Development and Therapy
69. Hepatotoxicity effect of short-term Bradykinin potentiating factor in cholestatic rats
    Sohair Ramadan Fahmy, Ayman Saber Mohamed, Mohamed Hosney, Hanan A. Issa, Sarah Sayed Hassanein, Amel M. Soliman · 2018 · Toxicology Letters
70. Physiological hypoxia prevents bile salt‐induced apoptosis in human and rat hepatocytes
    Simon D. Hohenester, Timo Vennegeerts, Michaela M. Wagner, Ralf Wimmer, Heidrun Drolle, Christina Theresa Rieger, Gerald Denk, Christian Rust, Michael Fiegl · 2013 · Liver International
71. GLP-1 analogues: a new therapeutic approach to prevent ductopenia in cholangiopathies?
    Ulrich H. Beuers, Burkhard Göke · 2009 · Gut
72. Apoptosis: A Friend Or Foe?
    2006 · The Internet Journal of Pharmacology
73. An Integrated Pathogenetic Model of Primary Biliary Cholangitis
    Elias Kouroumalis, Ioannis Tsomidis, Argyro Voumvouraki · 2025 · Livers
74. Intestinal capacity to digest and absorb carbohydrates is maintained in a rat model of cholestasis
    Esther Los, Henk Wolters, Frans Stellaard, Folkert Kuipers, Henkjan J. Verkade, Edmond H.H.M. Rings · 2007 · American Journal of Physiology-Gastrointestinal and Liver Physiology
75. Natural bioactive compounds reprogram bile acid metabolism in MAFLD: Multi-target mechanisms and therapeutic implications
    Dongjie Wu, Jing Liu, Ziwei Guo, Liang Wang, Ziang Yao, Qingjuan Wu, Yanping Lu, Wenliang Lv · 2025 · International Immunopharmacology
76. The Most Severe Paradigm of Early Cardiovascular Disease: Hutchinson-Gilford Progeria. Focus on the Role of Oxidative Stress
    Chiara Mozzini, Angela Setti, Sebastiano Cicco, Mauro Pagani · 2021 · Current Problems in Cardiology
77. Reversal of deleterious effect of hypertension on the liver by inhibition of endoplasmic reticulum stress
    Nur Banu Bal, Sevtap Han, Saba Kiremitçi, Mecit Orhan Uludağ, Emine Demirel-Yılmaz · 2020 · Molecular Biology Reports
78. Ursodeoxycholic acid induces autophagy via LC3B to suppress hepatocellular carcinoma in vivo and in vitro.
    Fengyan Wang, Chengyong Qin, Li Yang, Wendong Qu, Hui Liu, Bin Li, Jianni Qi, Juan Liu, Liyun Wang · 2017 · PubMed Central
79. Characterization of Radioprotective, Radiomitigative and Bystander Signaling Modulating Effects of Endogenous Metabolites – Phenylacetate, Ursodeoxycholate and Tauroursodeoxycholate – on HCT116 Human Colon Carcinoma Cell Line
    Dusan Vukmirovic, Nguyen T. K. Vo, Colin B Seymour, David Rollo, Carmel E Mothersill · 2019 · Radiation Research
80. Tauroursodeoxycholic Acid Induces Liver Regeneration and Alleviates Fibrosis Through GATA3 Activation
    Chongyang Bai, Xiaojing Song, Jiexi Yan, Jun Chen Xu, Yongqiang Zhou, Zongbin Sun, Qiuxia Zheng, Yue Zhang, Ruixi Chen, Xiaoyi Jin et al. · 2025 · Biomedicines
81. Microwave-Assisted Synthesis of New Steroidal Thiosemicarbazones Derived from methyl 3-Oxocholanate under Solvent-Free Conditions
    Zhigang Zhao, Xingli Liu, Lingling Liu, Guohua Li · 2010 · Journal of Chemical Research
82. Hepatitis B virus surface proteins accelerate cholestatic injury and tumor progression in Abcb4-knockout mice
    Daniel Zahner, Hannah Glimm, Tomomitsu Matono, Yuri Churin, Diran Agaid Herebian, Ertan Mayatepek, Kernt Köhler, Stefan Gattenlöhner, Anne Stinn, Annette Tschuschner et al. · 2017 · Oncotarget
83. Protection of hepatocytes from apoptosis by a novel substance from actinomycetes culture medium
    Yang LIU, Saori Takahashi, Hironobu Ogasawara, Han Geuk Seo, Masami Kawagoe, Fujiko Hirasawa, Naxin Guo, Yasuharu Ueno, Takashi KAMEDA, Toshihiro Sugiyama · 2005 · Biomedical Research
84. URSODEOXYCHOLIC ACID REGULATES CASPASE-9 AND ROS PRODUCTION IN PROTECTING CARDIOMYOCYTES AGAINST HYPOXIA
    Noorul Izzati Hanafi, Siti Hamimah Sheikh Abdul Kadir, Anis Syamimi Mohamed, Julina Md Noor, Nora Julianna Osman, Rosfaiizah Siran, Sharaniza Ab Rahim, Narimah Abdul Hamid Hasani · 2017 · Jurnal Teknologi
85. Inhibition of glucagon secretion from pancreatic α-cells by the bile acid TUDCA involves a S1PR2-PI3K pathway
    Joel Alves da Silva, Jean Franciesco Vettorazzi, Sergi Soriano, Eva Bru-Tarí, Talía Boronat‐Belda, Manuel Castellano-Muñoz, Patrícia Cristine Borck, Rosane Aparecida Ribeiro, Gabriela Moreira Soares, Camila Lubaczeuski et al. · 2025 · The Journal of Nutritional Biochemistry
86. Role of P38 MAPK in Bile Formation and Cholestasis
    M. S. Anwer · 2018 · Gastroenterology & Hepatology Research
87. Progeria, atherosclerosis and clonal hematopoiesis: links and future perspectives
    Chiara Mozzini · 2020 · Mechanisms of Ageing and Development
88. Interplay of autophagy, apoptosis, and senescence in primary biliary cholangitis
    Elias Kouroumalis, Ioannis Tsomidis, Argyro Voumvouraki · 2023 · Exploration of Digestive Diseases
89. Anti-apoptotic therapeutic approaches in liver diseases: do they really make sense?
    Karen Bannert, Angela Kuhla, Kerstin Abshagen, Brigitte Vollmar · 2014 · APOPTOSIS
90. Tauroursodeoxycholic acid improves viability of artificial RBCs
    Shin Hee Hong, Kang Jun Yoon, Key‐Hwan Lim, Yun Jung Um, Jin Gu Cho, Young Joon Jo, Sang Gyu Park · 2016 · Biochemical and Biophysical Research Communications
91. Ursodeoxycholic and tauroursodeoxycholic acids as antiapoptotic agents: modulation of Parkinson's disease
    Noha F. Abdelkader · 2020 · Elsevier eBooks
92. Chemical chaperones reverse early suppression of regulatory circuits during unfolded protein response in B cells from common variable immunodeficiency patients
    Darshak Bhatt, Razvan Costin Stan, Raffaele Pinhata, María Aparecida de Andrade Moreira Machado, Shuvadeep Maity, Charlotte Cunningham‐Rundles, Christine Vogel, Maristela Martins De Camargo · 2019 · Clinical & Experimental Immunology
93. Transglutaminase‐mediated cytokeratin modifications implicated in bile‐acid‐induced hepatocyte death
    Hideki Tatsukawa, Haruka Nakagawa, Chin Mun Yee, Keiko Kuwata, Kiyotaka Hitomi · 2025 · FEBS Journal
94. Detrimental Role of CXCR3 in α-Naphthylisothiocyanate- and Triptolide-Induced Cholestatic Liver Injury
    Yuan Mei, Xinyu Li, Chao He, Yiying Zhang, Weichao Kong, Rufeng Xue, Xin Huang, Yaxiang Shi, Gang Tao, Mengtao Xing et al. · 2023 · Chemical Research in Toxicology
95. Function of nuclear steroid receptors in apoptosis: role of ursodeoxycholic acid
    Joana D. Amaral, Susana Solá, Clifford J. Steer, Cecília P Rodrigues · 2007 · Expert Review of Endocrinology & Metabolism
96. Iron and Bile Acids Synergize to Exacerbate Congenital Cholestatic Liver Injury via Ferroptosis
    Yudai Ohta, Yohei Kanamori, Ayato Maeda, Mohammad Saleh, Akihiro Nita, Takashi Matsumoto, Keiichi I. Nakayama, Toshiro Moroishi · 2025 · American Journal Of Pathology
97. Glycoursodeoxycholic acid regulates peritoneal monocytic myeloid-derived suppressor cells to alleviate systemic inflammation in decompensated cirrhosis
    Rui Wang, Binghong Wang, Bo Li, Jun Zhang, Yikang Li, Chenyi Jiang, Peixuan Ji, Ruqi Tang, Zhengrui You, Xiao Xiao et al. · 2026 · Journal of Autoimmunity
98. Tauroursodeoxycholic acid (TUDCA) ameliorates age‐related skeletal muscle loss
    Marina Uchôa Wall Barbosa De Carvalho, Letícia Barssotti, Lohanna M.B. dos Santos, Lucas Rodolfo de Oliveira Rosa, Maria Cristina Cintra Gomes‐Marcondes, EVERARDO M. CARNEIRO, Helena C.L. Barbosa, Lucas Zangerolamo · 2026 · The Journal of Physiology
99. [Oxidative stress and endoplasmic reticulum stress].
    Yoshito Ihara, Midori Ikezaki · 2010 · PubMed
100. Bile Acid as Therapeutic Agents
     Yoshihide Yamanashi, Tappei Takada, Hiroshi Suzuki · 2017 · Springer eBooks