Quality of life in patients with primary biliary cirrhosis
Open accessAbstract
The impact of primary biliary cirrhosis (PBC) on health-related quality of life (HRQOL) is poorly documented. We assessed quality of life in a group of 276 unselected patients with PBC using the Nottingham Health Profile (NHP). This is a generic scale that assesses six major areas commonly associated with HRQOL. Data were compared with those of a sex- and age-matched control group. The associations between NHP scores and the severity of PBC were tested. Patients (86% women) had a median age of 62 years (range 33-87). Most patients were treated with UDCA. PBC patients showed a strong statistically significant difference in energy compared to controls (respectively, 40.6 vs. 22.9, P < .0001) and had worse scores for emotional reactions (22.2 vs. 16.1, P < .005). No other differences were observed. No associations of the dimension subscores were found with biochemical liver tests, histological stages, or duration of the disease. Among the signs or symptoms, fatigue was the finding most often associated with the dimension subscores. In conclusion, patients with PBC feel that their overall quality of life is worse than that of the control population. This difference is mainly due to the decrease in the subscores of energy and emotional reactions, both associated with fatigue. These effects must be taken into account by clinicians when treating these patients, as they constitute the clinical outcomes that have the most impact on patients’ lifestyle and adherence to treatment. (Hepatology 2004;40:489-494.)
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Fatigue is the most common symptom in PBC, found in 50% to 78% of patients, and has a significant negative impact on quality of life.
“Fatigue is the most common symptom in PBC; it has been found in 50% to 78% of patients and has a significant negative impact on quality of life.(95)(96)”
From Primary Biliary Cholangitis: 2018 Practice Guidance from the American Association for the Study of Liver Diseases (2019) · cites this paper as [96]
The Associations Between NHP Scores and the Characteristics of PBC section reports a significant association between fatigue and worse overall quality of life. The Discussion calls fatigue the finding most often associated with quality-of-life scores, not the most common symptom, and reports prevalence across prior studies as 8%–80%, not 50%–78%. Page numbers are unavailable in our copy. (LLM, conf=0.88)
Experimental — accuracy not yet measuredFatigue is the most common symptom in PBC, found in 50% to 78% of patients, and has a significant negative impact on quality of life.
“Fatigue is the most common symptom in PBC; it has been found in 50% to 78% of patients and has a significant negative impact on quality of life.(95)(96)”
From Primary Biliary Cholangitis: 2018 Practice Guidance from the American Association for the Study of Liver Diseases (2019) · cites this paper as [95]
The Associations Between NHP Scores and the Characteristics of PBC section reports a significant association between fatigue and worse overall quality of life. The Discussion says fatigue was the finding most often associated with quality-of-life subscores, not that it was the most common symptom; it gives a prevalence range of 8%–80% across prior studies, not 50%–78%. Page numbers are unavailable in our copy. (LLM, conf=0.88)
Experimental — accuracy not yet measured
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
The citation lists haven’t been fetched yet
References 15 · Cited by 144
- Authors
- Poupon, R. E., Chrétien, Y., Chazouillères, O., Poupon, R., & Chwalow, J.
- Affiliations
- Inserm (FR)
- Hôtel-Dieu de Paris (FR)
- Corresponding author
- Poupon, Renée Eugénie
- Poupon, Raoul
- Venue
- Hepatology
- Published
- 2004-08
- Volume
- 40
- Issue
- 2
- Pages
- 489-494
- ISSN
- 0270-9139 (ISSN-L)
- OpenAlex
- W2012421341
- Cited by
- 144
- References
- 15
- Citations by year
- 2026: 5 · 2025: 7 · 2024: 3 · 2023: 8 · 2022: 2 · 2021: 4 · 2020: 2 · 2019: 7 · 2018: 8 · 2017: 5 · 2016: 2 · 2015: 4 · 2014: 3 · 2013: 8 · 2012: 7
- FWCI
- 7.38
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Hepatology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Institut National de la Santé et de la Recherche Médicale
- Topics
- Health Sciences › Medicine › Hepatology › Liver Diseases and Immunity
- Health Sciences › Medicine › Surgery › Pediatric Hepatobiliary Diseases and Treatments
- Health Sciences › Medicine › Hepatology › Liver Disease and Transplantation
- Keywords
- primary biliary cirrhosis, health-related quality of life, Nottingham Health Profile, fatigue, energy, emotional responses, ursodeoxycholic acid, disease severity, medication adherence
- MeSH terms
- Adult, Aged, Aged, 80 and over, Cholagogues and Choleretics, Emotions, Energy Metabolism, Fatigue, Female, Humans, Liver Cirrhosis, Biliary, Male, Middle Aged, Prospective Studies, Quality of Life, Ursodeoxycholic Acid, Case-Control Studies, Sickness Impact Profile
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
