Absence of peroxisomes in mouse hepatocytes causes mitochondrial and ER abnormalities†

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1. Combination therapy of lovastatin and AMP ‐activated protein kinase activator improves mitochondrial and peroxisomal functions and clinical disease in experimental autoimmune encephalomyelitis model
   Inderjit Singh, Devadoss J. Samuvel, Seungho Choi, Nishant Saxena, Avtar Kaur Singh, Je‐Seong Won · 2018 · Immunology
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3. Mitochondrial free radical theory of aging: Who moved my premise?: MFRTA: Who moved my premise?
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4. Octadecaneuropeptide (ODN) Induces N2a Cells Differentiation through a PKA/PLC/PKC/MEK/ERK-Dependent Pathway: Incidence on Peroxisome, Mitochondria, and Lipid Profiles
   Amira Namsi, Thomas Nury, Amira Sayed Khan, Jérôme Leprince, David Vaudry, Claudio Caccia, Valerio Leoni, Atanas G. Atanasov, Marie‐Christine Tonon, Olfa Masmoudi‐Kouki et al. · 2019 · Molecules
5. A pex1 missense mutation improves peroxisome function in a subset of Arabidopsis pex6 mutants without restoring PEX5 recycling
   Kim L. Gonzalez, Sarah E. Ratzel, Kendall H. Burks, Charles H. Danan, Jeanne M. Wages, Bethany K. Zolman, Bonnie Bartel · 2018 · Proceedings of the National Academy of Sciences
6. Differential Effects of Insulin-Deficient Diabetes Mellitus on Visceral vs. Subcutaneous Adipose Tissue—Multi-omics Insights From the Munich MIDY Pig Model
   Florian Flenkenthaler, Erik Ländström, Bachuki Shashikadze, Mattias Backman, Andreas Blutke, Julia Philippou‐Massier, Simone Renner, Martin Hrabě de Angelis, Rüdiger Wanke, Helmut Blum et al. · 2021 · Frontiers in Medicine
7. Multifaceted Nature of Lipid Droplets in Viral Interactions and Pathogenesis
   Luis Herrera-Moro Huitron, Luis Adrián De Jesús‐González, Macario Martínez Castillo, José Manuel Ulloa-Aguilar, Carlos Cabello-Gutiérrez, Addy Cecilia Helguera‐Repetto, Julio García‐Cordero, Moisés León‐Juárez · 2023 · Microorganisms
8. Slc25a17 Gene Trapped Mice: PMP34 Plays a Role in the Peroxisomal Degradation of Phytanic and Pristanic Acid
   Paul P. Van Veldhoven, Evelyn de Schryver, Stephen G. Young, An Zwijsen, Marc Fransen, Marc Espeel, Myriam I Baes, Elke Van Ael · 2020 · Frontiers in Cell and Developmental Biology
9. Mitochondrial disruption in peroxisome deficient cells is hepatocyte selective but is not mediated by common hepatic peroxisomal metabolites
   Abhijit Babaji Shinde, Ritesh Kumar Baboota, Simone W. Denis, Ursula Loizides‐Mangold, Annelies Peeters, Marc Espeel, Ana Rita Malheiro, Howard Riezman, Stefan Vinckier, Frédéric Maxime Vaz et al. · 2017 · Mitochondrion
10. Induced pluripotent stem cell models of Zellweger spectrum disorder show impaired peroxisome assembly and cell type-specific lipid abnormalities
    Xiao Ming Wang, Wing Yan Yik, Peilin Zhang, Wange Lu, Ning Huang, Bo Ram Kim, Darryl K. Shibata, Madison Zitting, Robert Hsiu-Ping Chow, Ann B. Moser et al. · 2015 · Stem Cell Research & Therapy
11. Hepatosteatosis in peroxisome deficient liver despite increased β-oxidation capacity and impaired lipogenesis
    Annelies Peeters, Johannes V. Swinnen, Paul P. Van Veldhoven, Myriam I Baes · 2011 · Biochimie
12. Loss of functional peroxisomes leads to increased mitochondrial biogenesis and reduced autophagy that preserve mitochondrial function
    Lijun Chi, Dorothy Lee, Sharon Leung, Guanlan Hu, Bijun Wen, Paul Delgado-Olguı́n, Miluska Vissa, Ren Li, John Hunter Brumell, Peter Kijun Kim et al. · 2023 · Cellular and Molecular Life Sciences
13. Peroxisome deficient aP2–Pex5 knockout mice display impaired white adipocyte and muscle function concomitant with reduced adrenergic tone
    Katrin Martens, Astrid Bottelbergs, Annelies Peeters, Frank Jacobs, Marc Espeel, Peter Carmeliet, Paul P. Van Veldhoven, Myriam I Baes · 2012 · Molecular Genetics and Metabolism
14. Renal tubular peroxisomes are dispensable for normal kidney function
    Camille Ansermet, Gabriel Centeno, Sylvain Pradervand, Dušan Harmáček, Andy Garcia, Jean Daraspe, Sai Kocherlakota, Myriam I Baes, Yohan Bignon, Dmitri Firsov · 2022 · JCI Insight
15. Nonylphenol-mediated CYP induction is PXR-dependent: The use of humanized mice and human hepatocytes suggests that hPXR is less sensitive than mouse PXR to nonylphenol treatment
    Linda C. Mota, Christina Barfield, Juan P. Hernandez, William S. Baldwin · 2011 · Toxicology and Applied Pharmacology
16. Peroxisome Deficiency in Cochlear Hair Cells Causes Hearing Loss by Deregulating BK Channels
    Xiaolong Fu, Peifeng Wan, Ling Lü, Yingcui Wan, Ziyi Liu, Guodong Hong, Shengda Cao, Xiuli Bi, Jing Zhou, Ruifeng Qiao et al. · 2023 · Advanced Science
17. Cell Type-Selective Loss of Peroxisomal β-Oxidation Impairs Bipolar Cell but Not Photoreceptor Survival in the Retina
    Daniëlle Swinkels, Yannick Das, Sai Kocherlakota, Stefan Vinckier, Eric J. M. Wever, Antoine H. C. van Kampen, Frédéric Maxime Vaz, Myriam I Baes · 2022 · Cells
18. Organelle stress and alterations in interorganelle crosstalk during liver fibrosis
    Saloni Sinha, Nora Ali Hassan, Robert E. Schwartz · 2023 · Hepatology
19. Ubiquitin ligase MARCH5 controls the formation of mitochondria-derived pre-peroxisomes
    Jun Zheng, Jing Chen, Zhihe Cao, Kou‐Juey Wu, Jinhui Wang, Yusong Guo, Min Zhuang · 2024 · Developmental Cell
20. Liver disease predominates in a mouse model for mild human Zellweger spectrum disorder
    Kevin Berendse, Maxim Boek, Marion J. Gijbels, Nicole N. van der Wel, Femke C. C. Klouwer, Marius A. van den Bergh Weerman, Abhijit Babaji Shinde, Rob Ofman, Bwee Tien Poll‐The, Sander M. Houten et al. · 2019 · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease
21. Potential Involvement of Peroxisome in Multiple Sclerosis and Alzheimer’s Disease
    Amira Zarrouk, Thomas Nury, Hammam I. El Hajj, Catherine Gondcaille, Pierre Andreoletti, Thibault Moreau, Mustapha Cherkaoui‐Malki, Johannes Berger, Mohamed Hammami, Gérard Lizard et al. · 2020 · Advances in experimental medicine and biology
22. Targeting lipid droplets and lipid droplet-associated proteins: a new perspective on natural compounds against metabolic diseases
    Xinyue Jiang, Hongzhan Wang, Kexin Nie, Yang Gao, Chen Shen, Yueheng Tang, Zhi Wang, Hao Su, Hui Dong · 2024 · Chinese Medicine
23. Proteasome inhibitors induce auditory hair cell death through peroxisome dysfunction
    Joon No Lee, Seul‐Gi Kim, Jae‐Young Lim, Se-Jin Kim, Seong‐Kyu Choe, Raekil Park · 2014 · Biochemical and Biophysical Research Communications
24. Clinical and Neuroimaging Spectrum of Peroxisomal Disorders
    Ai Peng Tan, Fabrício Guimarães Gonçalves, Abeer Almehdar, Bruno Passebon Soares · 2018 · Topics in Magnetic Resonance Imaging
25. ACOX3 Dysfunction as a Potential Cause of Recurrent Spontaneous Vasospasm of Internal Carotid Artery
    Joon-Tae Kim, So Yeon Won, Kyung Wook Kang, Sang‐Hoon Kim, Man‐Seok Park, Kang‐Ho Choi, Tai‐Seung Nam, Simone W. Denis, Sacha Ferdinandusse, Ji Eun Lee et al. · 2020 · Translational Stroke Research
26. Zebrafish model of human Zellweger syndrome reveals organ-specific accumulation of distinct fatty acid species and widespread gene expression changes
    Shigeo Takashima, Shoko Takemoto, Kayoko Toyoshi, Akiko Ohba, Nobuyuki Shimozawa · 2021 · Molecular Genetics and Metabolism
27. Autophagy and the peroxisome proliferator-activated receptor signaling pathway: A molecular ballet in lipid metabolism and homeostasis
    Pouria Kiani, Elaheh Sadat Khodadadi, Ali Nikdasti, Sahar Yarahmadi, Mobina Gheibi, Zeynab Yousefi, Sajad Ehtiati, Sheida Yahyazadeh, Sayed Mohammad Shafiee, Motahareh Taghizadeh et al. · 2025 · Molecular and Cellular Biochemistry
28. Early-onset Purkinje cell dysfunction underlies cerebellar ataxia in peroxisomal multifunctional protein-2 deficiency
    Stephanie De Munter, Simon Verheijden, Esther Vanderstuyft, Ana Rita Malheiro, Pedro Brites, David Gall, Serge N. Schiffmann, Myriam I Baes · 2016 · Neurobiology of Disease
29. Developmental and Inherited Liver Disease
    Alberto Quaglia, Eve A. Roberts, Michael S Torbenson · 2017 · Elsevier eBooks
30. Developmental Roles of D-bifunctional Protein-A Zebrafish Model of Peroxisome Dysfunction
    Yong‐Il Kim, Sushil Bhandari, Joon No Lee, Kyeong‐Won Yoo, Se-Jin Kim, Gi‐Su Oh, Hyungjin Kim, Meyoung Cho, Jong-Young Kwak, Hong‐Seob So et al. · 2014 · Molecules and Cells
31. Lipid droplet - organelle crosstalk and its implication in cancer
    Jing Quan, Chunhong Zhang, Xue Chen, Xinfei Cai, Xiangjian Luo · 2025 · Progress in Biophysics and Molecular Biology
32. Loss of pex5 sensitizes zebrafish to fasting due to deregulated mitochondria, mTOR, and autophagy
    Sushil Bhandari, Yong‐Il Kim, In-Koo Nam, KwangHeum Hong, Yunju Jo, Kyeong‐Won Yoo, Weifang Liao, Jae‐Young Lim, Seong‐Jin Kim, Jae‐Young Um et al. · 2023 · Cellular and Molecular Life Sciences
33. Crosstalk between Lipids and Non-Alcoholic Fatty Liver Disease
    Divyavani Gowda, Chandra Shekhar, Siddabasave Gowda B. Gowda, Yifan Chen, Shu‐Ping Hui · 2023 · Livers
34. Peroxisomal import stress activates integrated stress response and inhibits ribosome biogenesis
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35. Hepatobiliary pathology
    Jay H. Lefkowitch · 2006 · Current Opinion in Gastroenterology
36. Microporation is an efficient method for siRNA-induced knockdown of PEX5 in HepG2 cells: evaluation of the transfection efficiency, the PEX5 mRNA and protein levels and induction of peroxisomal deficiency
    Barbara Ahlemeyer, Julia-Franziska Vogt, Vera Michel, Petra Hahn-Kohlberger, Eveline Baumgart‐Vogt · 2014 · Histochemistry and Cell Biology
37. Long-Term Cholic Acid Treatment in a Patient with Zellweger Spectrum Disorder
    James E. Heubi, Warren P. Bishop · 2018 · Case Reports in Gastroenterology
38. Normal plasmalogen levels are maintained in tissues from mice with hepatocyte-specific deletion in peroxin 5
    Ernst R. Werner, Daniëlle Swinkels, Viktorija Jurić, Fabian Dorninger, Myriam I Baes, Markus Andreas Keller, Johannes Berger, Katrin Watschinger · 2022 · Brain Research Bulletin
39. Cisd2 Preserves the Youthful Pattern of the Liver Proteome during Natural Aging of Mice
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40. Potential biomarkers in hypoglycemic brain injury
    Shuquan Zhao, Zi-Hao Liu, Longda Ma, Yin M, Yiwu Zhou · 2023 · Forensic Science Medicine and Pathology
41. Obesity, metabolic syndrome, and disorders of energy balance
    Ram Weiss, Robert H. Lustig · 2014 · Elsevier eBooks
42. Peroxisomal Malfunction Caused by Mitochondrial Toxin 3-NP: Protective Role of Oxytocin.
    Mehdi Moslemi, Fereshteh Motamedi, Sareh Asadi, Fariba Khodagholi · 2019 · Europe PMC (PubMed Central)
43. Hepatocyte-specific deletion of peroxisomal protein PEX13 results in disrupted iron homeostasis
    Gautam Rishi, Maneet Bhatia, Eriza S. Secondes, Michelle Melino, Denis I. Crane, V. Nathan Subramaniam · 2020 · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease
44. Mouse Models to Study Peroxisomal Functions and Disorders: Overview, Caveats, and Recommendations
    Sai Kocherlakota, Daniëlle Swinkels, Paul P. Van Veldhoven, Myriam I Baes · 2023 · Methods in molecular biology
45. Peroxisomal Disorders in Children
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46. Developmental and Inherited Liver Disease
    Alberto Quaglia, Eve A. Roberts, Michael S Torbenson · 2023 · Elsevier eBooks
47. Lipid Droplet Metabolism Across Eukaryotes: Evidence from Yeast to Humans
    Jie Huang, Xiaojia Chen, Feilong Zhang, Margarita Lin, Guorong Lin, Zhizhen Zhang · 2020 · Journal of Evolutionary Biochemistry and Physiology
48. Mitochondrial Signaling
    Nuno Raimundo, Lorena Fernández-Mosquera, King Faisal Yambire · 2016 · Springer eBooks
49. Impaired neurogenesis and associated gliosis in mouse brain with PEX13 deficiency
    Rani Sadia Rahim, James A. St John, Denis I. Crane, Adrian Cuda Banda Meedeniya · 2017 · Molecular and Cellular Neuroscience
50. Peroxisome import stress impairs ribosome biogenesis and induces integrative stress response through eIF2α phosphorylation
    Kerui Huang, Jinoh Kim, Pham Thuy Tien Vo, Ting Miao, Hua Bai · 2020 · bioRxiv (Cold Spring Harbor Laboratory)
51. A Mouse Model System to Study Peroxisomal Roles in Neurodegeneration of Peroxisome Biogenesis Disorders
    Yuichi Abe, Shigehiko Tamura, Masanori Honsho, Yukio Fujiki · 2020 · Advances in experimental medicine and biology
52. Implication de l'acide docosanoïque (C22 0) et des acides gras à très longue chaîne (acide tétracosanoïque (C24 0), acide hexacosanoïque ( C26 0) dans la maladie d'Alzheimer : aspects biologiques et cliniques
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53. Organellar crosstalk as a potential therapeutic target for rare neurodegenerative diseases
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54. Metabolomic Profiling Reveals Brain Lipid Alterations in PEX7-Deficient Models of Rhizomelic Chondrodysplasia Punctata
    R. Sankhe, Meredith I. Williams, Wedad Fallatah, Laura Palmer Mackay, Mary Layne Brown, Pranjali Bhagwat, Sarah H. Elsea, Nancy Braverman, Michael F. Wangler · 2025 · Biomolecules
55. PEX5 integrates the p38 MAPK signaling pathway and taurine metabolism to regulate senescence in lung fibroblasts
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56. Peroxisome Assembly, Degradation, and Disease
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57. Longitudinal study of liver disease progression in the PEX1-Gly844Asp mouse model of mild Zellweger Spectrum Disorder
    Lingxiao Chen, Hong Yul Choi, Catherine Argyriou, Monica Hsieh, Erminia Di Pietro, Wei Cui, Esther Nuebel, Caroline Daneault, Matthieu Ruiz, Daniel Charpentier et al. · 2025 · bioRxiv (Cold Spring Harbor Laboratory)
58. Activités cytotoxiques et pro-oxydantes d'acides gras à très longue chaîne sur des oligodendrocytes murins sauvages et déficients en Abcd1 et Acox1 : application à la physiopathologie de l'X-ALD et de la P-NALD
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59. Mechanisms Linking Lipid Metabolism and Longevity in Yeast
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60. Mouse Models with Peroxisome Biogenesis Defects
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61. Mechanisms Underlying Longevity Regulation and Extension by Genetic, Dietary and Pharmacological Interventions in the Yeast Saccharomyces Cerevisiae
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62. Lactate dehydrogenase is C-terminally extended by stop codon read-through which targets this isoform into the peroxisomes
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63. Communication between the Endoplasmic Reticulum and Peroxisomes in Mammalian Cells
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64. Hepatic peroxisome and its implications on cardiac function, inflammation and aging
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