CAR and PXR agonists stimulate hepatic bile acid and bilirubin detoxification and elimination pathways in mice†

Cited by (352)

Items 301–352 of 352

1. Gut metabolites: key factors in the cross-talk between the gut microbiota and tumor immunotherapy
   Lizhu Zeng, Yuxin Ren, Hui Huang, Qiurong Wang, Hong Li, Jieyu Song, Feng He, Li J · 2026 · Frontiers in Immunology
2. Novel treatment strategies for unconjugated hyperbilirubinemia
   Frans J.C. Cuperus · 2011 · University of Groningen research database (University of Groningen / Centre for Information Technology)
3. Geneticheskiye aspekty etiologii biliarnoy atrezii
   M. Kh. Isaeva, Vera Belova, Dmitriy O. Korostin, А. В. Дегтярева · 2020 · Вестник Российского государственного медицинского университета
4. Signaling Pathways in Liver Diseases: PXR and CAR
   Catherine A. M. Stedman, Michael Downes, Christopher Liddle · 2009 · Springer eBooks
5. The Role of Cholesterol in the Pathogenesis of Hypertension- Associated Nonalcoholic Steatohepatitis
   Yuan Yuan, Hisao Naito, Tamie Nakajima · 2018 · InTech eBooks
6. The Role of Oral Phenobarbital Therapy in the Management of Neonates with Prolonged Unconjugated Hyperbilirubinemia
   Zuhair M. Al-Musawi, Sabah N. Al-Musawi, Inas Muayad Mohammed Ali · 2019 · AL-QADISIYAH MEDICAL JOURNAL
7. Oral treatment of unconjugated hyperbilirubinemia
   Anja M. Hafkamp · 2006 · University of Groningen research database (University of Groningen / Centre for Information Technology)
8. Learning from the pregnane X receptor: how to fight one aggressor with two strategies
   Christian Rust, Ulrich H. Beuers · 2009 · Liver International
9. Bile acids and their receptors
   Thierry Claudel, Michael A Trauner · 2015
10. SUMOylation of ABCD3 restricts bile acid synthesis and regulates metabolic homeostasis
    Vanessa Goyon, Aurèle Besse‐Patin, Rodolfo Zunino, Mai Nguyen, Étienne Coyaud, Jonathan M. Lee, Bich Nguyen, Brian Raught, Heidi May McBride · 2022 · bioRxiv (Cold Spring Harbor Laboratory)
11. Constitutive Androstane Receptor Regulates Bile Acid Homeostasis and Metabolism During Liver Regeneration
    Zhou, Weinan, Chembazhi, Ullas Valiya, Huang, Jiansheng, Bangru, Sushant, Dean, Angela E., Asokakumar, Anjana, Kalsotra, Auinash, Rudnick, David A., Anakk, Sayeepriyadarshini · 2026 · Cellular and Molecular Gastroenterology and Hepatology
12. XENOSENSOR REGULATION OF ENZYMES AND TRANSPORTERS IN DRUG EXPOSURE AND DISEASE
    Matthew D. Merrell · 2011 · UA Campus Repository (The University of Arizona)
13. Orphan drugs in development for primary biliary cirrhosis: challenges and progress
    Keith D. Lindor, Ahmad Hassan Ali, Thomas Byrne · 2015 · Orphan Drugs Research and Reviews
14. Beyond PXR and CAR, Regulation of Xenobiotic Metabolism by other Nuclear Receptors
    Martin Wagner, Gernot Zollner, Michael Trauner · 2008 · Wiley eBooks
15. TRANSLATIONAL REGULATORY MECHANISMS OF THE RAT AND HUMAN MULTIDRUG RESISTANCE PROTEIN 2
    Yuanyuan Zhang · 2008 · UKnowledge (University of Kentucky)
16. Efeitos de hipolipemiantes sobre a expressão de CYP3A4 e CYP3A5 in vitro e in vivo
    Maria Alice V. Willrich · 2011
17. In vitro thyroid hormone metabolism: effects of nuclear receptor activation on the metabolic profiles of thyroxine in rat and human hepatocytes
    Vicki M. Richardson · 2019 · Carolina Digital Repository (University of North Carolina at Chapel Hill)
18. Utility of Genetically Modified Animal Models for Drug Metabolism and Drug Transporters
    Andrew J. Bessire, Kuresh A. Youdim, Susan I. Hurst, Caroline A. Lee · 2012 · Wiley eBooks
19. Guiding ES cell differentiation into the definitive endoderm lineages
    Nobuaki Shiraki, Yuichiro Higuchi, Shoen Kume · 2010 · Inflammation and Regeneration
20. 940 LOSS OF KERATIN 19 PREDISPOSES TO THE DEVELOPMENT OF CHOLESTATIC LIVER DISEASE
    Yang Chen, Nurdan Güldiken, M. Bishr Omary, Johannes Haybäck, Pavel Strnad · 2012 · Journal of Hepatology
21. EFFECT OF BILE ACID FEEDING AND SEQUESTRATION ON LIVER BILE ACID COMPOSITION AND GENE REGULATION IN MICE
    Peizhen Song · 2010
22. NF-kB et les xénorécepteurs CAR et PXR
    Jean‐Marc Pascussi, Marie‐José Vilarem · 2008
23. Behazun-gatzen garraioaren fisiologia
    Yuri Rueda, Patricia Apichueta, Olatz Fresnedo · 2011 · EKAIA Euskal Herriko Unibertsitateko Zientzi eta Teknologi Aldizkaria
24. Dysregulated Bile Acid Synthesis, Metabolism and Excretion in a High Fat-Cholesterol Diet-Induced Fibrotic Steatohepatitis in Rats
    Xiaofang JiaHisao · 2013
25. Reactivation of hepatic organic anion transporters in different forms of acquired cholestasis by nuclear hormone receptor activators
    I. V. Martin, Andreas Geier · 2009 · Springer eBooks
26. TEMPORAL EFFECTS OF FESCUE TOXICOSIS AND HEAT
    Raja S. Settivari · 2007
27. A conserved bile acid biosynthesis and secretion pathway in Caenorhabditis elegans
    Ju‐Ling Liu · 2013 · eScholarship@McGill (McGill)
28. ABC Transporters Involved in Cholestasis
    Frans J.C. Cuperus, Julien Gautherot, Emina Halilbasic, Thierry Claudel, Michael Trauner · 2017 · Methods and principles in medicinal chemistry
29. The Systems Biology of Transporters – Targeting the Regulatory System for Transporters (FXR/RXR)
    Antimo Gioiello, Maura Marinozzi, Bruno Cerra, Chiara Custodi, Roberto Pellicciari, Antonio Macchiarulo · 2017 · Methods and principles in medicinal chemistry
30. Nuclear Receptor Regulation
    Makoto Makishima · 2017 · Springer eBooks
31. Bile Acids and Bilirubin in Liver Immunology
    Ci Zhu, Thierry Claudel, Michael Trauner · 2020 · Springer eBooks
32. Genetic aspects of biliary atresia etiology
    M. Kh. Isaeva, Vera Belova, Dmitriy O. Korostin, А. V. Degtyareva · 2020 · Bulletin of Russian State Medical University
33. New approaches to improve prediction of drug-induced liver injury
    Melanie Adler · 2012 · Online Publication Service of Würzburg University (Würzburg University)
34. Hyperbilirubinaemia
    Peter L. M. Jansen · 2007
35. Role of polymorphisms in genes involved in bile acid detoxification pathways in primary sclerosing cholangitis
    Tom H. Karlsen, Kirsten Muri Boberg, Elisabeth Schrumpf · 2007 · Springer eBooks
36. Molecular mechanisms controlling bile metabolism in health and disease
    Martin C. Carey · 2007 · Springer eBooks
37. Efflux Transporters
    Paiboon Jungsuwadee, Mary E. Vore · 2017 · Elsevier eBooks
38. State-of-the-Art Lecture III: Genetics of cholestasis
    Peter L. M. Jansen · 2007 · Springer eBooks
39. Postoperative liver (dys)function
    Kim M.C. van Mierlo · 2022 · Research Publications (Maastricht University)
40. Gut microbiota affects the role of mPXR agonist PCN in alleviating sepsis-induced liver injury by regulating YAP activation
    Chenghua Wu, Shuang Hu, Dan Li, Xiaowen Jiang, Guofang Bi, Peng Wang, Hui Ouyang, Jian-Hong Fang, Xiao Yang, Guofang Bi · 2025 · International Immunopharmacology
41. Etude du rôle du récepteur nucléaire CAR, Constitutive Androstane Receptor, dans le métabolisme des lipides et la susceptibilité à l'athérosclérose
    Anne-Laure Sberna · 2011 · theses.fr (ABES)
42. Etude des xénorécepteurs CAR (NR1I3) et PXR (NR1I2) : identification d’un nouveau gène cible de CAR (SPOT14) et d’une nouvelle isoforme de PXR (PXR-small) dans l'hépatocyte humain
    Cyril Breuker · 2010 · theses.fr (ABES)
43. Rôle du récepteur nucléaire CAR dans la pathogénèse dimorphique de la NAFLD (Non-Alcoholic Fatty Liver Disease), induite par un régime gras ou par l'exposition à des contaminants alimentaires
    Fabiana Oliviero · 2021 · theses.fr (ABES)
44. Farnesoid x Receptor Deficiency Promotes Hepatocytic Injury in Cyp2c70 ‐Deficient Mice With a Human‐Like Bile Acid Composition
    Hilde D. de Vries, Jinxiao Li, Kirill Ustyantsev, Milaine V. Hovingh, Niels L. Mulder, Rick Havinga, Anna Palmiotti, Krisztina de Bruyn, Brecht J. Attema, Ellen Weersing et al. · 2026 · Liver International
45. Constitutive AMPK activation prevents hepatocellular carcinoma development through inhibition of HNF4α activity
    Zhen Sun, Bernard Linarés, Cassidy Urdiales, Fiyad Al-sarmi, Boyuan Sang, Nagireddy Putluri, Jeanine L. Van Nostrand · 2026 · Science Advances
46. Circulating 4β-hydroxycholesterol as a biomarker of CYP3A4 activity: beyond drug development
    Michael N. Passarelli · 2026 · Steroids
47. Estradiol-induced disruption of CAR signaling leads to bile acid homeostasis dysregulation in a murine model of intrahepatic cholestasis of pregnancy and is reversed by CAR ligands
    Maria Bajnokova, Hana Laštůvková, Martin Ambrož, Milos Hroch, Alžběta Štefela, Jana Hricová, Lucie Smutná, Jolana Schreiberová, Otto Kučera, Dina Faeq Manna et al. · 2026 · Acta Pharmaceutica Sinica B
48. Nuclear receptor-mediated control of bile composition: implications for gallstone formation
    Aditya Sharma, Rajani Sharma · 2026 · Irish Journal of Medical Science (1971 -)
49. SMRT regulation of nuclear receptors orchestrates bile acid homeostasis
    Kyeongkyu Kim, Sungsoon Fang, Suk-Hyun Hong, Han Cho, Mathias Leblanc, Sandra Jacinto, Bernd Schnabl, Annette R. Atkins, Ruth T. Yu, Christopher Liddle et al. · 2026 · Experimental & Molecular Medicine
50. New approach methodologies for in vitro detection of chemical-induced cholestatic liver injury
    Amy Maerten, Alexandra-Costina Avîrvarei, Mathieu Vinken · 2026 · Archives of Toxicology
51. Multi-Omics Analysis Reveals the Potential Role of Inonotus obliquus in Mit-Igating Hemolytic Jaundice
    Fan Yang, Siyi Xie, Wenjing Yang, Chuanhong Zhu, Yurong Chen, Haozhuo Yang, Hongxia Yuan, Qingshan Li · 2026 · Nutrients
52. Bile acid signaling in health and disease
    Zhezhe Fan, Mengyi He, Taiping Liang, 张必利, Na Zhao, Pan Li · 2026 · Molecular Biomedicine