Phagocytosis of apoptotic bodies by hepatic stellate cells induces NADPH oxidase and is associated with liver fibrosis in vivo

Zhan, Shan-Shan; Jiang, Joy X.; Wu, Jian; Halsted, Charles; Friedman, Scott L.; Zern, Mark A.; Torok, Natalie J.

doi:10.1002/hep.21093

Phagocytosis of apoptotic bodies by hepatic stellate cells induces NADPH oxidase and is associated with liver fibrosis in vivo

Hepatic stellate cell activation is a main feature of liver fibrogenesis. We have previously shown that phagocytosis of apoptotic bodies by stellate cells induces procollagen α1 (I) and transforming growth factor beta (TGF-β) expression in vitro . Here we have further investigated the downstream …