Hepatocellular adenoma subtype classification using molecular markers and immunohistochemistry
Abstract
Unlabelled Hepatocellular adenomas (HCA) with activated beta-catenin present a high risk of malignant transformation. To permit robust routine diagnosis to allow for HCA subtype classification, we searched new useful markers. We analyzed the expression of candidate genes by quantitative reverse transcription polymerase chain reaction QRT-PCR followed by immunohistochemistry to validate their specificity and sensitivity according to hepatocyte nuclear factor 1 alpha (HNF1alpha) and beta-catenin mutations as well as inflammatory phenotype. Quantitative RT-PCR showed that FABP1 (liver fatty acid binding protein) and UGT2B7 were downregulated in HNF1alpha-inactivated HCA (P Conclusion We refined HCA classification and its phenotypic correlations, providing a routine test to classify hepatocellular adenomas using simple and robust immunohistochemistry.
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Positive β-catenin and glutamine synthetase staining are good predictors of CTNNB1-mutation.
“However, it has recently been reported that positive β-catenin and glutamine synthetase staining are good predictors of CTNNB1-mutation (34), further strengthening the idea that CTNNB1-class is primarily driven by CTNNB1-mutation.”
From Wnt-Pathway Activation in Two Molecular Classes of Hepatocellular Carcinoma and Experimental Modulation by Sorafenib (2012) · cites this paper as [34]
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Lachenmayer, A., Alsinet, C., Savic, R., Cabellos, L., Toffanin, S., Hoshida, Y., Villanueva, A., Minguez, B., Newell, P., Tsai, H.-W., et al. (2012) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-11-2322 · Cited by 306 · see citing works
Hale, G., Liu, X., Hu, J., Xu, Z., Che, L., Solomon, D., Tsokos, C., Shafizadeh, N., Chen, X., Gill, R., et al. (2016) · Modern Pathology · doi:10.1038/modpathol.2016.122 · Cited by 73 · see citing works
- Authors
- Bioulac-Sage, P., Rebouissou, S., Thomas, C., Blanc, J.-F., Saric, J., Sa Cunha, A., Rullier, A., Cubel, G., Couchy, G., Imbeaud, S., Balabaud, C., & Zucman-Rossi, J.
- Affiliations
- Inserm (FR)
- Centre Hospitalier Universitaire de Bordeaux (FR)
- Centre National de la Recherche Scientifique (FR)
- ORCID
- Venue
- Hepatology
- Published
- 2007-09
- Volume
- 46
- Issue
- 3
- Pages
- 740-748
- ISSN
- 0270-9139 (ISSN-L)
- OpenAlex
- W2061683650
- Cited by
- 590
- References
- 0
- Citations by year
- 2026: 14 · 2025: 15 · 2024: 13 · 2023: 21 · 2022: 17 · 2021: 22 · 2020: 28 · 2019: 29 · 2018: 39 · 2017: 37 · 2016: 39 · 2015: 52 · 2014: 37 · 2013: 51 · 2012: 37
- FWCI
- 21.78
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Hepatology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Hepatology › Hepatocellular Carcinoma Treatment and Prognosis
- Health Sciences › Medicine › Hepatology › Liver physiology and pathology
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Wnt/β-catenin signaling in development and cancer
- Keywords
- hepatocellular adenoma, CTNNB1 mutation, liver fatty acid binding protein, glutamine synthetase, SAA2, C-reactive protein, inflammatory hepatocellular adenoma, telangiectasia, hepatocellular carcinoma risk, molecular markers, immunohistochemical markers
- MeSH terms
- Adult, Female, Glutamate-Ammonia Ligase, Humans, Immunohistochemistry, Liver Neoplasms, Male, Biomarkers, Tumor, Glucuronosyltransferase, Adenoma, Liver Cell, Fatty Acid-Binding Proteins, beta Catenin, Hepatocyte Nuclear Factor 1-alpha
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