The epidermal growth factor receptor ligand amphiregulin participates in the development of mouse liver fibrosis†

Perugorria, Maria J., Latasa, M. Ujue, Nicou, Alexandra, Cartagena‐Lirola, Hugo, Castillo, Josefa, Goñi, Saioa, Vespasiani‐Gentilucci, Umberto, Zagami, Maria G. +4 more·2008·Hepatology

Cited by (151)

Items 101–151 of 151

  1. Loss of Gab1 adaptor protein in hepatocytes aggravates experimental liver fibrosis in mice
    Takashi Kizu, Yuichi Yoshida, Kunimaro Furuta, Satoshi Ogura, Mayumi Egawa, Norihiro Chatani, Mina Hamano, Takayo Takemura, Hisao Ezaki, Yoshihiro Kamada et al. · 2015 · American Journal of Physiology-Gastrointestinal and Liver Physiology
  2. Gene Expression and Apoptosis Levels in Cumulus Cells of Patients with Polymorphisms of FSHR and LHB Undergoing in Vitro Fertilization Program
    Liana Bosco, Giovanni Ruvolo, Claudio Luparello, Stefania Ferrari, Domenico Valerio, Daniele Santi, Paola Piomboni, Elena Sarcina, Monica Lispi, Maria Carmela Roccheri · 2017 · Cellular Physiology and Biochemistry
  3. Current Perspectives on the Immunosuppressive Niche and Role of Fibrosis in Hepatocellular Carcinoma and the Development of Antitumor Immunity
    Tomoko Aoki, Naoshi Nishida, Masatoshi Kudo · 2021 · Journal of Histochemistry & Cytochemistry
  4. Left atrial single-cell transcriptomics reveals amphiregulin as a surrogate marker for atrial fibrillation
    Yuya Suzuki, Takuo Emoto, Shunsuke Sato, Takeshi Yoshida, Mitsuhiko Shoda, Hiromi Endoh, Manabu Nagao, Tomoyo Hamana, Taishi Inoue, Tomohiro Hayashi et al. · 2024 · Communications Biology
  5. Inflammatory monocyte-derived amphiregulin mediates intestinal fibrosis in Crohn’s disease by activating PI3K/AKT
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  6. Activation of epidermal growth factor receptor gene is involved in transforming growth factor-β-mediated fibronectin expression in a chondrocyte progenitor cell line
    Inoue · 2010 · International Journal of Molecular Medicine
  7. Ultraviolet B-induced expression of amphiregulin and growth differentiation factor 15 in human lens epithelial cells.
    Hiromi Osada, Yoshino Yoshitake, Takayuki Ikeda, Yasuhito Ishigaki, Takanobu Takata, Naohisa Tomosugi, Hiroshi Sasaki, Hideto Yonekura · 2011 · Europe PMC (PubMed Central)
  8. The splicing regulator SLU7 is required to preserve DNMT1 protein stability and DNA methylation
    Miriam Recalde, María Gárate‐Rascón, María Elizalde, María Azkona, Maria Ujue Latasa, Marina Bárcena‐Varela, Bruno Sangro, Maite G. Fernández‐Barrena, Matias Antonio Avila, María Arechederra et al. · 2021 · Nucleic Acids Research
  9. The hepatocyte epidermal growth factor receptor ( EGFR ) pathway regulates the cellular interactome within the liver fibrotic niche
    Ester Gonzalez‐Sanchez, Javier Vaquero, Daniel Caballero‐Díaz, Jan Grzelak, Noel P. Fusté, Esther Bertrán, Josep Amengual, Juan García‐Sáez, Beatriz Martín‐Mur, Marta Ortova Gut et al. · 2024 · The Journal of Pathology
  10. Exocrine Gland Morphogenesis: Insights into the Role of Amphiregulin from Development to Disease
    Margherita Sisto, Loredana Lorusso, Giuseppe Ingravallo, Sabrina Lisi · 2017 · Archivum Immunologiae et Therapiae Experimentalis
  11. Efficacy of epidermal growth factor in suppressing inflammation and proliferation in pterygial fibroblasts through interactions with microenvironmental M1 macrophages
    Soo Jin Lee, Ahra Koh, Seung Hyeun Lee, Kyoung Woo Kim · 2024 · Scientific Reports
  12. Treg derived Amphiregulin protects from murine lupus nephritis via tissue reparative effects
    Laura-Isabell Ehnold, Simon Melderis, Julia Hagenstein, Matthias T. Warkotsch, Viona Laas, Frederic Christian Feindt, Hui Min Wu, Tobias Bruno Huber, Florian Grahammer, Oliver M. Steinmetz · 2025 · Scientific Reports
  13. Amphiregulin in Fibrotic Diseases and Cancer
    Tae Rim Kim, Beomseok Son, Chun Geun Lee, Han-Oh Park · 2025 · International Journal of Molecular Sciences
  14. Potential role of epidermal growth factor receptors (EGFR) signaling in the pathogenesis and management of hepatocellular carcinoma
    Samah Saleh Ahmed Al-Awadhi, Prakash Patil, Praveenkumar Shetty, Padma K Shetty, Reshma Arun Shetty, Vijith Vittal Shetty · 2025 · Bioimpacts
  15. Potential therapeutic target of EGF on bile duct ligation model and biliary atresia children
    Qipeng Zheng, Mengdi Li, Lingzhi Chen, Cong Zhang, Yilin Zhao, Gengxin Liu, Fang Yang, Jianghua Zhan · 2023 · Pediatric Research
  16. Mechanisms of main components in Curcuma longa L. on hepatic fibrosis based on network pharmacology and molecular docking: A review
    Qiang Han, Jiahui Zhu, Peng Zhang · 2023 · Medicine
  17. Hepatocyte-specific Epidermal Growth Factor Receptor Deletion Promotes Fibrosis but has no Effect on Steatosis in Fast-food Diet Model of Metabolic Dysfunction-associated Steatotic Liver Disease
    Shehnaz Bano, Matthew A. Copeland, John W. Stoops, Anne V. Orr, Siddhi Jain, Shirish Paranjpe, Raja Gopal Reddy Mooli, Sadeesh Kumar Ramakrishnan, Joseph D. Locker, Wendy M. Mars et al. · 2024 · Cellular and Molecular Gastroenterology and Hepatology
  18. Carfilzomib shows therapeutic potential for reduction of liver fibrosis by targeting hepatic stellate cell activation
    Ayana Fujiwara, Keisuke Takemura, Anna Tanaka, Misaki Matsumoto, Masato Katsuyama, Takeshi Okanoue, Kanji Yamaguchi, Yoshito Itoh, Kazumi Iwata, Kikuko Amagase et al. · 2024 · Scientific Reports
  19. Overexpression of Heparin-Binding Epidermal Growth Factor-Like Growth Factor Mediates Liver Fibrosis in Transgenic Mice
    Yongze Guo, Qian Ding, Lei Chen, Chenguang Ji, Huiyao Hao, Jia Wang, Wei Qi, Xiao‐Li Xie, Junji Ma, Aidi Li et al. · 2017 · The American Journal of the Medical Sciences
  20. Amphiregulin alleviated concanavalin A-induced acute liver injury via IL-22
    Qili Wu, Jingrou Chen, Xiaoli Hu, Yinhong Zhu, Shu‐Juan Xie, Chang You Wu, Zhong Pei, Shiqiu Xiong, Yanwen Peng · 2020 · Immunopharmacology and Immunotoxicology
  21. The Immune Microenvironment: New Therapeutic Implications in Organ Fibrosis
    Xiangqi Chen, Chuan Fen Wu, Fei Tang, Jingyue Zhou, Li Mo, Yanping Li, Jinhan He · 2025 · Advanced Science
  22. Amphiregulin: a potential therapeutic target for tissue fibrosis
    M.H. Wang, Jian Liu, Shiliang Li, Miaomiao Zheng, R.Y. Qu, M. Xiang · 2025 · Trends in Pharmacological Sciences
  23. Clinical significance of amphiregulin in patients with chronic kidney disease
    Yuki Osakabe, Yoshinori Taniguchi, Kazu Hamada‐Ode, Yoshiko Shimamura, Satoshi Inotani, Hirofumi Nishikawa, Tatsuki Matsumoto, Taro Horino, Shimpei Fujimoto, Yoshio Terada · 2024 · Clinical and Experimental Nephrology
  24. Animal Models of Cutaneous and Hepatic Fibrosis
    Gideon Piers Smith · 2011 · Progress in molecular biology and translational science
  25. Targeted elimination of activated hepatic stellate cells by an anti‐epidermal growth factor‐receptor single chain fragment variable antibody‐tumor necrosis factor‐related apoptosis‐inducing ligand (scFv425‐sTRAIL)
    Mohammad Arabpour, Klaas Poelstra, Wijnand Helfrich, Edwin Bremer, Hidde J. Haisma · 2014 · The Journal of Gene Medicine
  26. Research progress of epidermal growth factor receptor in metabolic dysfunction‐associated steatotic liver disease and related diseases
    Ziwen Wang, Ze Jin, Zhi-fan Xiong · 2025 · Diabetes Obesity and Metabolism
  27. Genistein Produces Hepatoprotection through Modulating EGFR Expression and Phosphorylation in Experimental Fibrosis
    Rodriguez Fragoso L, Alvarez Ayala E · 2016 · Journal of Liver
  28. DNA-damaging chemotherapy reshapes cardiac-resident macrophage composition and function
    Ruijun He, Farid F. Kadyrov, Andrew L. Koenig, Pan Ma, Andrea L. Bredemeyer, Mandy M. Chan, Joel D. Schilling, Shibali Das, Joseph S. Lagas, Daniel Kreisel et al. · 2026 · Science Immunology
  29. Animal Models of Fibrosis in Human Disease
    Gideon Piers Smith · 2013 · Elsevier eBooks
  30. The Therapeutic Potential of Farm Dust Extracts in a Mouse Model of Eosinophilic Inflammation
    Korkmaz, Rabia Ülkü, Omony, Jimmy, Tan, Xiaomei, Klotz, Markus, Dragunas, Guilherme, Chen, Sirui, Shankhwar, Soni, Ertüz, Zeynep, Müller, Christoph, Ragab, Mohab et al. · 2026 · Allergy
  31. Amphiregulin-producing TH2 cells facilitate esophageal fibrosis of eosinophilic esophagitis
    Tatsuya Kaneko, Chiaki Iwamura, Masahiro Kiuchi, Akane Kurosugi, Miki Onoue, Tomoaki Matsumura, Tetsuhiro Chiba, Toshinori Nakayama, Naoya Kato, Kiyoshi Hirahara · 2024 · Journal of Allergy and Clinical Immunology Global
  32. The novel protein C9orf116 promotes rat liver cell line BRL-3A proliferation
    Chunyan Zhang, Cuifang Chang, Weiming Zhao, Hang Gao, Qiwen Wang, Deming Li, Fuchun Zhang, Shifu Zhang, Cunshuan Xu · 2017 · PLoS ONE
  33. AREG (amphiregulin (schwannoma-derived growth factor))
    Carmen Berasain, MA Avila · 2011 · Atlas of Genetics and Cytogenetics in Oncology and Haematology
  34. Pharmacological Impacts of Mucopolysacccharide Polysulfates in the Epidermis Involves Inhibition of Amphiregulin‐Mediated Signals in Keratinocytes
    Ryo Hirase, Tomoyuki Fujita, Tomohiro Miyai, Hiroshi Kawasaki, Haruhiko Koseki · 2024 · Experimental Dermatology
  35. The effect of amphiregulin on equine endometrial fibroblasts: in vitro responses of fibroblast derived from non-fibrotic and fibrotic endometrium
    Anna Wójtowicz, Agnieszka Sadowska, K.K. Piotrowska-Tomala, Anna Zuzanna Szóstek-Mioduchowska · 2025 · Reproductive Biology
  36. Signaling Pathways as Potential Therapeutic Targets in Hepatocarcinogenesis
    Yeliz Yılmaz, Aysim Güneş, Hande Topel, Neşe Atabey · 2017 · Journal of Gastrointestinal Cancer
  37. Tissue Remodeling and Repair During Type 2 Inflammation
    Alexander J. Chan, Jessica C. Jang, Meera Goh Nair · 2015 · Springer eBooks
  38. EASL Recognition Awardee 2013
    Mario Strazzabosco · 2013 · Journal of Hepatology
  39. Papel de SLU7 en la regulación epigenética de la expresión génica: control de la estabilidad de DNMT1 y la metilación del DNA
    Miriam Recalde · 2022
  40. Pro-inflammatory responses in BALB/c and C57BL/6 mice and the role of the Nrf2-amphiregulin axis in ventilator induced lung injury
    Stephanie Siegl, Stefan Uhlig · 2013 · RWTH Publications (RWTH Aachen)
  41. Nuevos mecanismos en la defensa natural del hígado frente a la lesión
    Carmen Berasain Lasarte, José Castillo, María Íñiguez, Matias Antonio Avila, Maria Ujue Latasa, Saioa Goñi, Jesús Prìeto, Maria Jesus Perugorria · 2009 · Gastroenterología y Hepatología
  42. A macrophage-pericyte axis directs tissue restoration via Amphiregulin-induced TGFβ activation
    Rucha V. Modak, Carlos M. Minutti, Felicity Macdonald, Fengqi Li, Danielle J. Smyth, David A. Dorward, Natalie F. Blair, Connor Husovsky, Andrew Muir, Ross Dobie et al. · 2018 · bioRxiv (Cold Spring Harbor Laboratory)
  43. The Characteristics of Peripheral Blood Mononuclear Cells in Takayasu Arteritis by Single Cell RNA Sequencing
    Qing Gao, Jinge Yu, Zuoguan Chen, Yongpeng Diao, Yuqing Miao, Yin Jinfeng, Junnan Jia, Weimin Li, Yongjun Li · 2021
  44. Papel de SLU7 en la diferenciación hepática y en la protección del hígado frente al daño: regulación de HNF4A
    María Gárate‐Rascón · 2022
  45. Comprehensive characterization of pyroptosis reveals novel molecular typing of biliary atresia as well as contributes to precise treatment
    Tengfei Li, Qipeng Zheng, Xueting Wang, Qianhui Yang, Mengdi Li, Xiaodan Xu, Yilin Zhao, Fangyuan Zhao, Ruifeng Zhang, Zhiru Wang et al. · 2023 · Research Square
  46. THE ROLE OF THE PRO-FIBROTIC GROWTH FACTOR AMPHIREGULIN IN RADIATION CYSTITIS
    Bernadette M. M. Zwaans, S Mota, Elijah P. Ward, Sarah N. Bartolone, Michael B. Chancellor · 2023 · Continence
  47. Dynamic dual regulation of amphiregulin in liver pathophysiology: balancing regeneration and disease progression via the EGFR axis
    Yi-li Wang, De-Jiang Zhou, Qiong Wang, Ye Zhang, Wen-Jing Yang, Wen Tan, Hao-Yu Wang, Xiao-Wan Chen, San-Qiang Li · 2026 · Frontiers in Medicine
  48. Mécanismes moléculaires de la tumorigénicité induite par l'isoforme A du récepteur de l'insuline dans les cellules de carcinome hépatocellulaire
    Eva Benabou · 2017
  49. Milk fat globule EGF and factor V/VIII domain containing (MFGE8) as a novel player in equine endometrial fibrosis
    Elena Zu Klampen, Gregor Neufeld, Claudia Klein · 2026 · Scientific Reports
  50. The Epidermal Growth Factor Receptor (EGFR) as a means of neuro-immune cross-conversation
    Katharina Gryksa, Maria Chiara Sibilia, Veit Rothhammer, Adrian Liston, Dietmar M. W. Zaiss · 2026 · Journal of Neuroinflammation
  51. Amphiregulin as a central dynamic network biomarker in inhaled polyhexamethylene guanidine triggered pulmonary fibrosis
    Jianzhong Zhang, Xin Li, Yuxin Ma, Wanjun Zhang, Zihao Han, Yanting Li, Jiayin Sun, Siqi Wang, Wei Han, Jing Liu et al. · 2026 · Journal of Hazardous Materials