Student or educator? Sign up with your school email and get 6 months of Pro free.
CoChat
Sign Up
Cited by 377

The DOI matches its Crossref record; 30 of the 30 references it cites were found in a registry or an index.

Fatty liver is associated with insulin resistance, risk of coronary heart disease, and early atherosclerosis in a large European population #

Open access
Gastaldelli, Amalia, Kozakova, Michaela, Hφjlund, Kurt, Flyvbjerg, Allan, Favuzzi, Angela, Mitrakou, Asimina, Balkau, Beverley·2009·Hepatology
DOI 10.1002/hep.22845
Open this paper in CoChat — free account

Abstract

Patients with fatty liver (FL) disease have a high risk of developing diabetes and cardiovascular diseases. The aim was to evaluate the association between FL, insulin resistance (IR), coronary heart disease (CHD) risk, and early atherosclerosis in a large European population (RISC Study). In 1,307 nondiabetic subjects (age 30-60 years) recruited at 19 centers, we evaluated liver enzymes, lipids, insulin sensitivity (by euglycemic-hyperinsulinemic clamp), glucose tolerance (by 75 g oral glucose tolerance test), carotid atherosclerosis as intima media thickness (IMT), CHD risk by the Framingham Heart study prediction score, and physical activity (by accelerometer). The presence of FL was estimated using the fatty liver index (FLI; >60, likelihood >78% presence FL; FLI <20 likelihood >91% absence of FL). Subjects were divided into three groups: G1: FLI <20 (n = 608); G3: FLI >60 (n = 234), G2: intermediate group (n = 465). Compared to G1, G3 included more men (70% versus 24%) and people with impaired glucose tolerance (23% versus 5%). IMT increased with FLI (G3 = 0.64 ± 0.08 versus G1 = 0.58 ± 0.08 mm, P < 0.0001). FLI was associated with increased CHD risk ( r = 0.48), low-density lipoprotein cholesterol ( r = 0.33), alanine aminotransferase ( r = 0.48), aspartate aminotransferase ( r = 0.25), systolic blood pressure ( r = 0.39) and IMT ( r = 0.30), and reduced insulin sensitivity ( r = −0.43), high-density lipoprotein cholesterol ( r = −0.50), adiponectin ( r = −0.42), and physical activity ( r = −0.16, all P < 0.0001). The correlations hold also in multivariate analysis after adjusting for age, gender, and recruiting center. Conclusion: In middle-age nondiabetic subjects, increased IMT, CHD risk, and reduced insulin sensitivity are associated with high values of FLI. (Hepatology 2009.)

Overview

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Integrity signals

Registry

Crossref · 10.1002/hep.22845

Cites

30 of 30 references verified0 citation errors · 0 not checkable

Statistics

Verification

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Citations

Cites

Show all 30 references

Cited by

See all 377

Metadata

Authors
Gastaldelli, A., Kozakova, M., Hφjlund, K., Flyvbjerg, A., Favuzzi, A., Mitrakou, A., & Balkau, B.
Venue
Hepatology
Publisher
Ovid Technologies (Wolters Kluwer Health)
Published
2009-05
Volume
49
Issue
5
Pages
1537-1544
ISSN
0270-9139 (ISSN-L)
DOI
10.1002/hep.22845
OpenAlex
W2037605083
Cited by
377
References
30
FWCI
19.33
Type
journal article
Language
en
Open access
bronze

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

How to cite

Cite CoChat for the checks on this page, and the paper for its own findings.

This page
CoChat. (2026). Citation check: Fatty liver is associated with insulin resistance, risk of coronary heart disease, and early atherosclerosis in a large European population #. https://app.cochat.ai/papers/10.1002/hep.22845
The paper
Gastaldelli, A., Kozakova, M., Hφjlund, K., Flyvbjerg, A., Favuzzi, A., Mitrakou, A., & Balkau, B. (2009). Fatty liver is associated with insulin resistance, risk of coronary heart disease, and early atherosclerosis in a large European population #. Hepatology. https://doi.org/10.1002/hep.22845

Data sources

Bibliographic data: Semantic Scholar, OpenAlex, Crossref.

Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.