Hepatic lipotoxicity and the pathogenesis of nonalcoholic steatohepatitis: The central role of nontriglyceride fatty acid metabolites†

Neuschwander‐Tetri, Brent A.·2010·Hepatology

DOI 10.1002/hep.23719

Cited by (1,000)

Items 501–600 of 1,000

Clinicopathological features of non‐alcoholic fatty liver disease
Kazushi Sugimoto, Yoshiyuki Takei · 2011 · Hepatology Research
Excess fructose and fatty acids trigger a model of non‑alcoholic fatty liver disease progression in vitro: Protective effect of the flavonoid silybin
Elena Grasselli, Francesca Baldini, Giulia Vecchione, Paulo Jorge Oliveira, Vilma A. Sardão, Adriana Voci, Piero Portincasa, Laura Vergani · 2019 · International Journal of Molecular Medicine
SGLT2 inhibitor ipragliflozin alone and combined with pioglitazone prevents progression of nonalcoholic steatohepatitis in a type 2 diabetes rodent model
Atsuo Tahara, Toshiyuki Takasu · 2019 · Physiological Reports
Hepatic lipid profile in mice fed a choline-deficient, low-methionine diet resembles human non-alcoholic fatty liver disease
Elisabeth M. Haberl, Rebekka Pohl, Lisa Rein‐Fischboeck, Marcus Höring, Sabrina Krautbauer, Gerhard Liebisch, Christa Buechler · 2020 · Lipids in Health and Disease
Metabolomic Predictors of Non-alcoholic Steatohepatitis and Advanced Fibrosis in Children
Kattayoun Kordy, Fan Li, David Lee, Jason Michael Kinchen, Michael Jew, Maria Eduarda La Rocque, Sara Zabih, Monica Saavedra, Cora L. Woodward, Nicole J. Cunningham et al. · 2021 · Frontiers in Microbiology
Impact of PNPLA3 p.I148M and Hepatic Steatosis on Long-Term Outcomes for Hepatocellular Carcinoma and HBsAg Seroclearance in Chronic Hepatitis B
Rei-Chi Hsueh, Wan-Jung Wu, Chih-Lin Lin, Chun-Jen Liu, Yi-Wen Huang, Jui-Ting Hu, Chih-Feng Wu, Feng-Yu Sung, Wen-Jie Liu, Ming-Whei Yu · 2022 · Journal of Hepatocellular Carcinoma
6-Gingerol regulates triglyceride and cholesterol biosynthesis to improve hepatic steatosis in MAFLD by activating the AMPK-SREBPs signaling pathway
Qingsong Xia, Fuer Lu, Yu Chen, Jingbin Li, Zhaoyi Huang, Ke Fang, Meilin Hu, Yujin Guo, Hui Dong, Lijun Xu et al. · 2023 · Biomedicine & Pharmacotherapy
A targeted analysis reveals relevant shifts in the methylation and transcription of genes responsible for bile acid homeostasis and drug metabolism in non-alcoholic fatty liver disease
Helgi B. Schiöth, Adrian E. Desai Boström, Susan K. Murphy, Wiebke Erhart, Jochen Hampe, Cynthia A. Moylan, Jessica Mwinyi · 2016 · BMC Genomics
Serum Monounsaturated Triacylglycerol Predicts Steatohepatitis in Patients with Non-alcoholic Fatty Liver Disease and Chronic Hepatitis B
Rui‐Xu Yang, Chunxiu Hu, Wanlu Sun, Qin Pan, Feng Shen, ZHEN KUN YANG, Qing Su, Guowang Xu, Jian‐Gao Fan · 2017 · Scientific Reports
Among Patients With NAFLD, Treatment of Dyslipidemia Does Not Reduce Cardiovascular Mortality
Omer Shahab, Rakesh Biswas, James M. Paik, Haley Bush, Pegah Golabi, Zobair M. Younossi · 2018 · Hepatology Communications
The generation of carcinogenic etheno-DNA adducts in the liver of patients with nonalcoholic fatty liver disease.
Kirsten B. Linhart, Katharina Glassen, Teresa Peccerella, Rüdiger Waldherr, Heinz Linhart, Helmut Bartsch, Helmut Karl Seitz · 2015 · PubMed Central
A novel dipeptide from potato protein hydrolysate augments the effects of exercise training against high-fat diet-induced damages in senescence-accelerated mouse-prone 8 by boosting pAMPK / SIRT1/ PGC-1α/ pFOXO3 pathway
Marthandam Asokan Shibu, Ting Wang, Ming-Fu Wang, Wan‐Teng Lin · 2020 · Aging
Long Non-Coding RNAs Involved in Progression of Non-Alcoholic Fatty Liver Disease to Steatohepatitis
Biljana Atanasovska, Sander S. Rensen, Glenn Marsman, Ronit Shiri‐Sverdlov, Sebo Withoff, Folkert Kuipers, Cisca Wijmenga, Bart van de Sluis, Jingyuan Fu · 2021 · Cells
Emerging Role of Nuclear Receptors for the Treatment of NAFLD and NASH
Ryan D. Welch, Cyrielle Billon, McKenna Losby, Gonzalo Bedia‐Diaz, Yuanying Fang, Amer Avdagic, Bahaa Elgendy, Thomas P. Burris, Kristine Griffett · 2022 · Metabolites
l -Methionine supplementation attenuates high-fat fructose diet-induced non-alcoholic steatohepatitis by modulating lipid metabolism, fibrosis, and inflammation in rats
Umashanker Navik, Vaibhav G. Sheth, Nisha Sharma, Kulbhushan Tikoo · 2022 · Food & Function
Ursolic acid protects hepatocytes against lipotoxicity through activating autophagy via an AMPK pathway
Fanyu Meng, Hua Ning, Zongxiang Sun, Fangfang Huang, Yanchuan Li, Xia Chu, Huimin Lu, Changhao Sun, Songtao Li · 2015 · Journal of Functional Foods
P2X7 Receptor as a Key Player in Oxidative Stress-Driven Cell Fate in Nonalcoholic Steatohepatitis
Saurabh Chatterjee, Suvarthi Das · 2015 · Oxidative Medicine and Cellular Longevity
Modes-of-Action Related to Repeated Dose Toxicity: Tissue-Specific Biological Roles of PPARγLigand-Dependent Dysregulation in Nonalcoholic Fatty Liver Disease
Merilin Al Sharif, Petko Alov, Vessela Vitcheva, Ilza K. Pajeva, Ivanka Tsakovska · 2014 · PPAR Research
Inhibition of lipogenesis reduces inflammation and organ injury in sepsis
Juan Pablo Idrovo, Weng-Lang Yang, Asha Jacob, Lana Corbo, Jeffrey M. Nicastro, Gene F. Coppa, Ping Wang · 2015 · Journal of Surgical Research
Gene Polymorphisms and Biological Effects of Vitamin D Receptor on Nonalcoholic Fatty Liver Disease Development and Progression
Evanthia Tourkochristou, Αthanasia Mouzaki, Christos K Triantos · 2023 · International Journal of Molecular Sciences
Fatty liver disease
Elizabeth M. Brunt, Brent A. Neuschwander‐Tetri, Alastair D. Burt · 2011 · Elsevier eBooks
Bacteroides uniformis-generated hexadecanedioic acid ameliorates metabolic-associated fatty liver disease
Daya Zhang, Da Li, Shi-Ju Chen, Lijun Zhang, Xuli Zhu, Fa-Di Chen, Chen Chen, Qi Wang, Yiping Du, Jian-Xin Xiong et al. · 2025 · Gut Microbes
Multi-omics insights into 6PPD- and 6PPDQ-induced gut-liver axis disruption and non-alcoholic fatty liver disease progression in zebrafish (Danio rerio)
Yu Feng, Hongyi Xian, Ruobing Bai, Zhiming Li, Hao Li, Long Zhang, Xiyun Huang, Yuji Huang, Boxuan Liang, Yanhong Deng et al. · 2025 · Journal of Hazardous Materials
MicroRNAs as biomarkers and regulators of nonalcoholic fatty liver disease
Xiao Lin Liu, Hai Xia Cao, Jian‐Gao Fan · 2016 · Journal of Digestive Diseases
A quantitative LC-MS/MS method for analysis of mitochondrial -specific oxysterol metabolism
Khushboo Borah, Olivia J. Rickman, Nikol Voutsina, Isaac Ampong, Dan Gao, Emma L. Baple, Irundika H.K. Dias, Andrew H. Crosby, Helen R. Griffiths · 2020 · Redox Biology
Defatting strategies in the current era of liver steatosis
Laura Mazilescu, Markus Selzner, Nazia Selzner · 2021 · JHEP Reports
Cisd2 Protects the Liver from Oxidative Stress and Ameliorates Western Diet-Induced Nonalcoholic Fatty Liver Disease
Yi‐Long Huang, Zhao‐Qing Shen, Chen‐Hua Huang, Yuan‐Chi Teng, Chao‐Hsiung Lin, Ting‐Fen Tsai · 2021 · Antioxidants
Safety, Tolerability, and Biologic Activity of AXA1125 and AXA1957 in Subjects With Nonalcoholic Fatty Liver Disease
Stephen A. Harrison, Seth J. Baum, Nadege Gunn, Ziad H Younes, Anita Kohli, Rashmee Patil, Margaret James Koziel, Harinder Chera, Jeff Zhao, Manu V. Chakravarthy · 2021 · The American Journal of Gastroenterology
Early-Life Exposure to Low-Dose Cadmium Accelerates Diethylnitrosamine and Diet-Induced Liver Cancer
Hongbo Men, Jamie L. Young, Wen-Qian Zhou, Haina Zhang, Xiang Wang, Jian-Xiang Xu, Qian Lin, Yi Tan, Yang Zheng, Lu Cai · 2021 · Oxidative Medicine and Cellular Longevity
Nobiletin Intake Attenuates Hepatic Lipid Profiling and Oxidative Stress in HFD-Induced Nonalcoholic-Fatty-Liver-Disease Mice
Zunli Ke, Chaowen Fan, Jun Li, La Wang, Haiyang Li, Weiyi Tian, Qi Yu · 2023 · Molecules
A positive feedback between cholesterol synthesis and the pentose phosphate pathway rather than glycolysis promotes hepatocellular carcinoma
Junjie Hu, Ningning Liu, David H. Song, Clifford J. Steer, Guohua Zheng, Guisheng Song · 2023 · Oncogene
Hepatoprotective Effect and Synergism of Bisdemethoycurcumin against MCD Diet-Induced Nonalcoholic Fatty Liver Disease in Mice
Sung‐Bae Kim, Ok‐Hwa Kang, Young‐Seob Lee, Sin‐Hee Han, Young-Sup Ahn, Seon-Woo Cha, Yun‐Soo Seo, Ryong Kong, Dong‐Yeul Kwon · 2016 · PLoS ONE
Pathophysiological mechanisms involved in non-alcoholic steatohepatitis and novel potential therapeutic targets
Fatima Higuera‐de la Tijera · 2015 · World Journal of Hepatology
Irbesartan Ameliorates Lipid Deposition by Enhancing Autophagy via PKC/AMPK/ULK1 Axis in Free Fatty Acid Induced Hepatocytes
Juan He, Jian Hua Ding, Qiuhua Lai, Xinke Wang, Aimin Li, Side Liu · 2019 · Frontiers in Physiology
Uncoupling Protein 2 Regulates Palmitic Acid-Induced Hepatoma Cell Autophagy
Jiaxin Lou, Yunjiao Wang, Xuejiang Wang, Ying Jiang · 2014 · BioMed Research International
Rosiglitazone Elicits an Adiponectin-Mediated Insulin-Sensitizing Action at the Adipose Tissue-Liver Axis in Otsuka Long-Evans Tokushima Fatty Rats
Jia Li, Yaoming Xue, Bo Zhu, Yonghua Pan, Yan Zhang, Chunxia Wang, Yuhao Li · 2018 · Journal of Diabetes Research
Significance of MR/OPN/HMGB1 axis in NAFLD-associated hepatic fibrogenesis
Min Tang, Haoyu Jia, Shuai Chen, Bo Yang, Bhuvanesh Kinish Patpur, Weiping Song, Yizhong Chang, Jing Li, Changqing Yang · 2020 · Life Sciences
Jiuzhuan Huangjing Pills relieve mitochondrial dysfunction and attenuate high-fat diet-induced metabolic dysfunction-associated fatty liver disease
Jian-Kang Mu, Lei Zi, Yanqin Li, Liping Yu, Zheng‐Guo Cui, Tingting Shi, Fan Zhang, Wen Gu, Jun-Jie Hao, Jie Yu et al. · 2021 · Biomedicine & Pharmacotherapy
B-cell lymphoma 6 alleviates nonalcoholic fatty liver disease in mice through suppression of fatty acid transporter CD36
Hao Zhang, Yue Li, Chao Zhang, Kun Huang, Jing Zhao, Sheng Le, Lang Jiang, Hao Liu, Peiwen Yang, Xiaoyue Xiao et al. · 2022 · Cell Death and Disease
Exercise inhibits JNK pathway activation and lipotoxicity via macrophage migration inhibitory factor in nonalcoholic fatty liver disease
Ni Cui, Hui Li, Yaoshan Dun, Jeffrey William Ripley-Gonzalez, Baiyang You, Dezhao Li, Yuan Liu, Ling Qiu, Cui Li, Suixin Liu · 2022 · Frontiers in Endocrinology
Role of Insulin Resistance and Diabetes in the Pathogenesis and Treatment of Nonalcoholic Fatty Liver Disease
Paola Portillo-Sánchez, Sahzene Yavuz, Fernando Bril, Kenneth J. Cusi · 2014 · Current Hepatology Reports
Increased expression of sterol regulatory element binding protein‑2 alleviates autophagic dysfunction in NAFLD
Chunwei Cheng, Xiaoling Deng, Keshu Xu · 2018 · International Journal of Molecular Medicine
Allomyrina dichotoma Larva Extract Ameliorates the Hepatic Insulin Resistance of High-Fat Diet-Induced Diabetic Mice
Kyong Kim, Gong Deuk Bae, Min‐Ho Lee, Eun‐Young Park, Dong Jae Baek, Chul Young Kim, Hee‐Sook Jun, Yoon Sin Oh · 2019 · Nutrients
Hesperetin protects against palmitate-induced cellular toxicity via induction of GRP78 in hepatocytes
Yana Geng, Zongmei Wu, Manon Buist‐Homan, Hans Blokzijl, Han J. Moshage · 2020 · Toxicology and Applied Pharmacology
Effect of Centaurium erythraea Rafn, Artemisia herba-alba Asso and Trigonella foenum-graecum L. on liver fat accumulation in C57BL/6J mice with high-fat diet-induced type 2 diabetes
Nawel Hamza, Bénédicte Berke, Catherine Chèze, Sébastien Marais, Simon Lorrain, Abdelilah Abdouelfath, R. Lassalle, Dominique Carles, Henri Gin, Nicholas D Moore · 2015 · Journal of Ethnopharmacology
Aggravation of nonalcoholic steatohepatitis by moderate alcohol consumption is associated with decreased SIRT1 activity in rats.
André Ferreira do Nascimento, Blanche C. Ip, Renata A M Luvizotto, Helmut Karl Seitz, Xiangdong Wang · 2013 · Europe PMC (PubMed Central)
Circulating Glycerolipids, Fatty Liver Index, and Incidence of Type 2 Diabetes: A Prospective Study Among Chinese
Zhenhua Niu, Qingqing Wu, Liang Sun, Qibin Qi, He Zheng, Huaixing Li, Rong Zeng, Xu Lin, Geng Zong · 2021 · The Journal of Clinical Endocrinology & Metabolism
Emerging pharmacological treatment options for MAFLD
Ángela Rojas, Carmen Lara, Rocío Múñoz‐Hernández, Sheila Gato, Javier Ampuero, Manuel Romero‐Gómez · 2022 · Therapeutic Advances in Endocrinology and Metabolism
Pathophysiological changes of the liver-muscle axis in end-stage liver disease: what is the right target?
Guillaume Hénin, Nicolas Lanthier, Géraldine Dahlqvist · 2022 · Acta gastro-enterologica belgica
Comparative study of the modulation of fructose/sucrose-induced hepatic steatosis by mixed lipid formulations varying in unsaturated fatty acid content
Rafat Ali Siddiqui, Zhidong Xu, Kevin A. Harvey, Thomas M. Pavlina, Michael J. Becker, Gary Paul Zaloga · 2015 · Nutrition & Metabolism
NAFLD is associated with methylation shifts with relevance for the expression of genes involved in lipoprotein particle composition
Jessica Mwinyi, Adrian E. Desai Boström, Claudia Pisanu, Susan K. Murphy, Wiebke Erhart, Clemens Schafmayer, Jochen Hampe, Cynthia A. Moylan, Helgi B. Schiöth · 2016 · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids
Tumor Necrosis Factor α-Converting Enzyme Inhibition Reverses Hepatic Steatosis and Improves Insulin Sensitivity Markers and Surgical Outcome in Mice
Vincent Erwin de Meijer, Hau D. Le, Jonathan A. Meisel, Anisha K. Sharma, Yury V. Popov, Mark Puder · 2011 · PLoS ONE
Lipid-Lowering Effects of a Novel Polysaccharide Obtained from Fuzhuan Brick Tea In Vitro
Wenjuan Yang, Shirui Cheng, Meng Liu, Nan Li, Jing Wang, Wenbo Yao, Fuxin Chen, Jian‐Wu Xie, Pin Gong · 2023 · Foods
Farnesoid X Receptor Agonism, Acetyl‐Coenzyme A Carboxylase Inhibition, and Back Translation of Clinically Observed Endpoints of De Novo Lipogenesis in a Murine NASH Model
Berangere Gapp, Marie Jourdain, Pauline Bringer, Benjamin Kueng, Delphine Weber, Arnaud Osmont, Stefan Zurbruegg, Judith Knehr, Rocco A. Falchetto, Guglielmo Roma et al. · 2019 · Hepatology Communications
Metabolically healthy and unhealthy obesity and the progression of liver fibrosis: A cross-sectional study
Helda Tutunchi, Fatemeh Naeini, Mehrangiz Ebrahimi‐Mameghani, Farzad Najafipour, Majid Mobasseri, Alireza Ostadrahimi · 2021 · Clinics and Research in Hepatology and Gastroenterology
Liver-Derived S100A6 Propels β-Cell Dysfunction in NAFLD
Surbhi Dogra, Debajyoti Das, Sujay Krishna Maity, Avishek Paul, Priya Rawat, P. Vineeth Daniel, Kausik Das, Souveek Mitra, Partha Chakrabarti, Prosenjit Mondal · 2022 · Diabetes
Hepatic damage caused by long-term high cholesterol intake induces a dysfunctional restorative macrophage population in experimental NASH
Ana Claudia Maretti-Mira, Matthew P. Salomon, Angela M. Hsu, Gary C. Kanel, Lucy Golden‐Mason · 2022 · Frontiers in Immunology
Novel metabolic phenotypes for extrahepatic complication of nonalcoholic fatty liver disease
Jiayi Yi, Lili Wang, Jiajun Guo, Xiangpeng Ren · 2023 · Hepatology Communications
Fibroblast growth factor signaling in non-alcoholic fatty liver disease and non-alcoholic steatohepatitis: Paving the way to hepatocellular carcinoma
Matthias Ocker · 2020 · World Journal of Gastroenterology
Novel Combinatorial Regimen of Garcinol and Curcuminoids for Non-alcoholic Steatohepatitis (NASH) in Mice
Muhammed A. Majeed, Shaheen Majeed, Kalyanam Nagabhushanam, Lincy Lawrence, Lakshmi Mundkur · 2020 · Scientific Reports
Non-alcoholic fatty liver disease in diabetes: When to refer to the hepatologist?
Reshu Khandelwal, Anuradha Supun Dassanayake, Hari S. Conjeevaram, Shivaram Prasad Singh · 2021 · World Journal of Diabetes
Processes exacerbating apoptosis in non-alcoholic steatohepatitis
Marta B. Afonso, Rui Eduardo Castro, Cecília M. P. Rodrigues · 2019 · Clinical Science
Electron microscopic observations in perfusion-fixed human non-alcoholic fatty liver disease biopsies
Verhaegh, Pauline, Wisse, Eddie, de Munck, Toon, Greve, Jan Willem, Verheij, Joanne, Riedl, Robert, Duimel, Hans, Masclee, Ad, Jonkers, Daisy, Koek, Ger · 2021 · Pathology
Lipid droplet deposition in the regenerating liver: A promoter, inhibitor, or bystander?
Yuelei Hu, Ruilin Wang, Juan Liu, Yunfang Wang, Jiahong Dong · 2023 · Hepatology Communications
Exploring Varied Treatment Strategies for Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD)
Amani Elshaer, David M. H. Chascsa, Blanca Lizaola‐Mayo · 2024 · Life
Bile acid signaling in MASLD: From pathogenesis to therapeutic applications
Benedikt Simbrunner, Rafael Paternostro, Thomas Reiberger, Michael Trauner · 2025 · Hepatology
Psoriasis and fatty liver: a harmful synergy
Antonio Olveira, Pedro Herranz, Marisa Montes · 2019 · Revista Española de Enfermedades Digestivas
The Epigenetic Regulation of RNA N6-Methyladenosine Methylation in Glycolipid Metabolism
Haiqing Yang, Yuting Li, Linying Huang, Miaochun Fang, Shun Xu · 2023 · Biomolecules
Dihydromyricetin ameliorated nonalcoholic steatohepatitis in mice by regulating the composition of serous lipids, bile acids and ileal microflora
Xiaolei Miao, Ping Luo, Jiao Liu, Junjun Wang, Yong Chen · 2023 · Lipids in Health and Disease
Protective Effects and Mechanism of Meretrix meretrix Oligopeptides against Nonalcoholic Fatty Liver Disease
Fangfang Huang, Shasha Zhao, Fangmiao Yu, Zuisu Yang, Guofang Ding · 2017 · Marine Drugs
Icosabutate Exerts Beneficial Effects Upon Insulin Sensitivity, Hepatic Inflammation, Lipotoxicity, and Fibrosis in Mice
Anita M. van den Hoek, Elsbet Jantine Pieterman, José W. van der Hoorn, Marta Iruarrizaga‐Lejarreta, Cristina Alonso, Lars Verschuren, Tore Skjæret, Hans M. G. Princen, David A. Fraser · 2019 · Hepatology Communications
Non-alcoholic steatohepatitis and the risk of myocardial infarction: A population-based national study
Sara Ghoneim, Aneesh Dhorepatil, Aun Raza Shah, Ganesh Ram, Subhan Ahmad, Chang Kim, Imad Asaad · 2020 · World Journal of Hepatology
Olive Oil Attenuates the Cholesterol-induced Development of Nonalcoholic Steatohepatitis Despite Increased Insulin Resistance in a Rodent Model
Roland Buettner, M. Ascher, Erwin Gäbele, Claus Hellerbrand, Robert Kob, Thomas Bertsch, Leo Cornelius Bollheimer · 2013 · Hormone and Metabolic Research
Dietary supplementation of magnolol alleviates fatty liver hemorrhage syndrome in postpeak Xinhua laying hens via regulation of liver lipid metabolism
Yi Chu, Yazhen Zheng, Yingying Li, Sisi Gui, Jingwu Zhao, Yaxiang Zhao, Xiaodong Chen · 2023 · Poultry Science
A CDAHFD-induced mouse model mimicking human NASH in the metabolism of hepatic phosphatidylcholines and acyl carnitines
Jie Yang, Manyun Dai, Ying Wang, Zheng Yan, Shuqi Mao, Aiming Liu, Caide Lu · 2024 · Food & Function
A rapid juvenile murine model of nonalcoholic steatohepatitis (NASH): Chronic intermittent hypoxia exacerbates Western diet-induced NASH
Jian Zhou, Yang Zhao, Yajing Guo, Ya‐Shuo Zhao, Han Liu, Jing Ren, Jie-Ru Li, En‐Sheng Ji · 2021 · Life Sciences
Effect of l-carnitine supplementation on lead acetate-induced liver cell apoptosis and inflammation: role of caspase-3 and glycogen synthase kinase-3β enzymes
Rania A. Abdel‐Emam, Marwa F. Ali · 2021 · Life Sciences
Effects of Moderate Alcohol Consumption in Non-Alcoholic Fatty Liver Disease
Peter Lemmer, Paul Peter Manka, Jan Best, Alişan Kahraman, Julia Kälsch, Ramiro Vilchez‐Vargas, Alexander Link, Hsin Chiang, Guido Gerken, Ali E. Canbay et al. · 2022 · Journal of Clinical Medicine
Dimethyl fumarate‐mediated Nrf2/ARE pathway activation and glibenclamide‐mediated NLRP3 inflammasome cascade inhibition alleviate type II diabetes‐associated fatty liver in rats by mitigating oxidative stress and inflammation
Durgesh Kumar Dwivedi, Gopabandhu Jena · 2023 · Journal of Biochemical and Molecular Toxicology
Liver Fibrosis Scores and Coronary Artery Disease: Novel Findings in Patients with Metabolic Dysfunction-Associated Fatty Liver Disease
Chuan Lu, Yan Chen, Yue Zhang, Xin Zhao · 2023 · Diabetes Metabolic Syndrome and Obesity
Metabolic dysfunction-associated steatotic liver disease heterogeneity: Need of subtyping
Shahid Habib · 2024 · World Journal of Gastrointestinal Pathophysiology
Gypenoside L inhibits hepatocellular carcinoma by targeting the SREBP2-HMGCS1 axis and enhancing immune response
Man‐Yu Xiao, Wenjing Pei, Si Li, Fangfang Li, Peng Xie, Hao-Tian Luo, Hye Hyun Yoo, Xiang‐Lan Piao · 2024 · Bioorganic Chemistry
Bioactive Moringa oleifera and Nigella sativa oils microcapsules alleviate high-fat-diet induced hepatic oxidative damage and inflammation in rats
Dina Mostafa Mohammed, Xiangliang Yang, Tamer Mohammed El-Messery, Xinnong Jiang, Hamdy A. Zahran, Yemane Habtemichael Gebremeskal, Amr Farouk · 2025 · Food Bioscience
Hepatic B cell leukemia-3 promotes hepatic steatosis and inflammation through insulin-sensitive metabolic transcription factors.
N. Gehrke, M. Wörns, Y. Huber, M. Hess, B. Straub, N. Hövelmeyer, A. Waisman, Y. O. Kim, D. Schuppan, P. Galle et al. · 2016 · Journal of Hepatology
1,3-dichloro-2-propanol induced lipid accumulation in HepG2 cells through cAMP/protein kinase A and AMP-activated protein kinase pathways via Gi/o-coupled receptors
Jing Lu, Baochen Fang, Yiying Zheng, Xin Yu, Guoren Huang, Zhenning Wang, Xuming Deng, Shuang Guan · 2017 · Environmental Toxicology and Pharmacology
Mouse models for investigating the underlying mechanisms of nonalcoholic steatohepatitis-derived hepatocellular carcinoma
Kazuki Takakura, Tsunekazu Oikawa, Yoichi Tomita, Yusuke Mizuno, Masanori Nakano, Chisato Saeki, Yuichi Torisu, Masayuki Saruta · 2018 · World Journal of Gastroenterology
The molecular basis for current targets of NASH therapies
Kamran Qureshi, Brent A. Neuschwander‐Tetri · 2019 · Expert Opinion on Investigational Drugs
The role of MRI in understanding the underlying mechanisms in obesity associated diseases
Sunanda D. Mitra, María Fernández-del-Valle, Jason E. Hill · 2016 · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease
Serum lysophospholipid levels are altered in dyslipidemic hamsters
Susana Suárez‐Garcia, Antoni Caimari, Josep M Del Bas-Prior, Manuel Suárez, Lluı́s Arola · 2017 · Scientific Reports
The role of hepatocyte-derived extracellular vesicles in liver and extrahepatic diseases
Shihui Li, Cheng Ran Fang, Zhuan Zhang, Ruizi Xu, Honglei Shi, Yongmin Yan · 2024 · Biomedicine & Pharmacotherapy
Lactiplantibacillus plantarum attenuate gossypol-induced hepatic lipotoxicity by altering intestinal microbiota for enriching microbial tryptophan metabolites in Nile tilapia (Oreochromis niloticus)
Fei-Fei Ding, Nan-Nan Zhou, Yue-Jian Mao, Jing Yang, Samwel Mchele Limbu, Jorge Galindo‐Villegas, Zhen‐Yu Du, Mei‐Ling Zhang · 2025 · Microbiome
n‐3 polyunsaturated fatty acids worsen inflammation and fibrosis in experimental nonalcoholic steatohepatitis
Angela Provenzano, Stefano Milani, Francesco Vizzutti, Wanda Delogu, Nadia Navari, Erica Novo, Marina Maggiora, Valter Maurino, Giacomo Laffi, Maurizio Parola et al. · 2014 · Liver International
Thioesterase induction by 2,3,7,8-tetrachlorodibenzo-p-dioxin results in a futile cycle that inhibits hepatic β-oxidation
Giovan N. Cholico, Russell R. Fling, Nicholas A. Zacharewski, Kelly Alana Fader, Rance Nault, Timothy Richard Zacharewski · 2021 · Scientific Reports
Aquaporin 9 Represents a Novel Target of Chronic Liver Injury That May Antagonize Its Progression by Reducing Lipotoxicity
Quancheng Cheng, Huiru Ding, Jinyu Fang, Xuan Fang, Huaicun Liu, Jianwei Wang, Chunhua Chen, Weiguang Zhang · 2021 · Oxidative Medicine and Cellular Longevity
Polyphenol-rich extract from loquat fruit peel prevents hyperlipidemia and hepato-nephrotoxicity in mice: in vivo study and in silico prediction of possible mechanisms involving identified polyphenols and/or their circulating metabolites
Imane Mokhtari, Chakib Mokhtari, Mohammadine Moumou, Mohamed Harnafi, Dragan Milenković, Souliman Amrani, Abdelmalek Hakmaoui, Hicham Harnafi · 2023 · Food & Function
Role of FXR in the development of NAFLD and intervention strategies of small molecules.
Jiachan Long, Yuanhang Xu, Xuerong Zhang, Bingxin Wu, Cai-Yan Wang · 2024 · Archives of Biochemistry and Biophysics
Effect of Vitamin E and Alpha Lipoic Acid in Nonalcoholic Fatty Liver Disease: A Randomized, Placebo-Controlled, Open-Label, Prospective Clinical Trial (VAIN Trial)
Patrick P Basu, Niraj James Shah, Mark M. Aloysius, Robert S. Brown · 2014 · Open Journal of Gastroenterology
Is mipomersen ready for clinical implementation? A transatlantic dilemma
Barbara Sjouke, Deepak Balak, Ulrich H. Beuers, Vlad Ratziu, Erik S.G. Stroes · 2013 · Current Opinion in Lipidology
Does Hepatic Oxidative Stress Enhance Activation of Nuclear Factor-E2-Related Factor in Patients with Nonalcoholic Steatohepatitis?
Yurimi Takahashi, Yoshimasa Kobayashi, Kazuhito Kawata, Kinya Kawamura, Shinichi Sumiyoshi, Hidenao Noritake, Shinya Watanabe, Takeshi Chida, Kenichi Souda, Takanori Sakaguchi et al. · 2013 · Antioxidants and Redox Signaling
The Basics of Metabolic Dysfunction–Associated Steatotic Liver Disease for Cardiologists
Muhammad Shahzeb Khan, Syed Sarmad Javaid, Amreen M. Dinani, Kara Wegermann, Ambarish Pandey, Ankeet S. Bhatt, Mark Dhinesh Muthiah, Harriette G.C. Van Spall, Faiez M. Zannad, Javed Butler et al. · 2025 · Journal of the American College of Cardiology