The Biliary HCO3 − Umbrella: A Unifying Hypothesis on Pathogenetic and Therapeutic Aspects of Fibrosing Cholangiopathies

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Items 201–300 of 351

1. Impact of hypoxia and AMPK on CFTR-mediated bicarbonate secretion in human cholangiocyte organoids
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3. Emerging pharmacologic therapies for primary sclerosing cholangitis
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5. Improving prognosis in primary biliary cholangitis – Therapeutic options and strategy
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6. Functional interplay between CFTR and pendrin: physiological and pathophysiological relevance
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7. Epigenetic Modifications in Generalized Autoimmune Epithelitis: Sjögren’s Syndrome and Primary Biliary Cholangitis
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8. A major step towards effective treatment evaluation in primary biliary cirrhosis.
   U. Beuers, K. Lindor · 2011 · Journal of Hepatology
9. Primary biliary cholangitis: primary autoimmune disease or primary secretory defect
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10. Approaches to the pathogenesis of primary biliary cirrhosis through animal models
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11. Primary sclerosing cholangitis and bile acids
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12. MMP ‐2 is a disease‐modifying gene in primary sclerosing cholangitis
    Kerem Sebib Korkmaz, Bert‐Jan F. de Rooij, Bart van Hoek, Marcel Janse, Minneke J. Coenraad, Johan J. van der Reijden, Rinse Karel Weersma, Robert Jack Porte, Philip W. Voorneveld, Andrzej G Baranski et al. · 2013 · Liver International
13. Genetic loss of the muscarinic M3 receptor markedly alters bile formation and cholestatic liver injury in mice
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14. Development and functional characterization of extrahepatic cholangiocyte lines from normal rats
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15. Ursodeoxycholate modulates bile flow and bile salt pool independently from the cystic fibrosis transmembrane regulator ( Cftr ) in mice
    Frank A.J.A. Bodewes, Marjan Wouthuyzen‐Bakker, Marcel J. C. Bijvelds, Rick Havinga, Hugo R. de Jonge, Henkjan J. Verkade · 2012 · American Journal of Physiology-Gastrointestinal and Liver Physiology
16. Ursodeoxycholic Acid at 18–22 mg/kg/d Showed a Promising Capacity for Treating Refractory Primary Biliary Cholangitis
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17. The many facets of bile acids in the physiology and pathophysiology of the human liver
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18. A Cholecystohepatic Shunt Pathway: Does the Gallbladder Protect the Liver?
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19. Active enterohepatic cycling is not required for the choleretic actions of 24-norUrsodeoxycholic acid in mice
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21. Galectin-3 and prohibitin 1 are autoantigens in IgG4-related cholangitis without clear-cut protective effects against toxic bile acids
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22. The role of soluble adenylyl cyclase in sensing and regulating intracellular pH
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23. Molecular Targets for the Treatment of Fibrosing Cholangiopathies
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24. Primary Biliary Cholangitis: Immunopathogenesis and the Role of Bile Acid Metabolism in Disease Progression
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25. IgG4-Related Cholangitis
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26. Primary sclerosing cholangitis – the Norwegian experience
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27. Autophagy – another piece of the puzzle towards understanding primary biliary cirrhosis?
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28. Relevance of Bile Acids in Cholangiocarcinoma Pathogenesis: Critical Revision and Future Directions
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29. Altered alkaline phosphatase activity in obese Zucker rats liver respect to lean Zucker and Wistar rats discussed in terms of all putative roles ascribed to the enzyme
    Vittorio Bertone, Eleonora Tarantola, Andrea Ferrigno, Enrico Gringeri, Sandro Barni, Mariapia Vairetti, Isabel Freitas · 2011 · European Journal of Histochemistry
30. Fundamentals of Bicarbonate Secretion in Epithelia
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31. Chronic fibrosing cholangiopathies: A consequence of a defective HCO3− “umbrella”?
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32. The Emerging Role of Soluble Adenylyl Cyclase in Primary Biliary Cholangitis
    Jung‐Chin Chang, Ulrich H. Beuers, Ronald P.J. Oude Elferink · 2017 · Digestive Diseases
33. Antibodies to the Muscarinic Acetylcholine Receptor M3 in Primary Biliary Cholangitis Inhibit Receptor Function on Cholangiocytes
    Christian Mayer, Beate E. Preuß, Julia M. Grottenthaler, Christoph P. Berg, Reinhild Klein · 2020 · Frontiers in Immunology
34. Implications of gut microbiota in autoimmune liver diseases
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35. Antibodies against multiple post-translationally modified proteins aid in diagnosis of autoimmune hepatitis and associate with complete biochemical response to treatment
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36. The PSC scientific community resource: an asset for multi-omics interrogation of primary sclerosing cholangitis
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37. Management of liver disease and portal hypertension in cystic fibrosis: a review
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38. Emerging Therapeutic Strategies in the Fight Against Primary Biliary Cholangitis
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39. Primary biliary cirrhosis: safety and benefits of established and emerging therapies
    James H. Tabibian, Keith D. Lindor · 2015 · Expert Opinion on Drug Safety
40. It is time to change primary biliary cirrhosis (PBC): New nomenclature from “cirrhosis“ to “cholangitis”, and upcoming treatment based on unveiling pathology
    Shinji Shimoda, Atsushi Tanaka · 2015 · Hepatology Research
41. Cost effectiveness of using ursodeoxycholic acid to treat primary biliary cholangitis
    Roger William Chapman · 2018 · British Journal of Hospital Medicine
42. Physiological hypoxia prevents bile salt‐induced apoptosis in human and rat hepatocytes
    Simon D. Hohenester, Timo Vennegeerts, Michaela M. Wagner, Ralf Wimmer, Heidrun Drolle, Christina Theresa Rieger, Gerald Denk, Christian Rust, Michael Fiegl · 2013 · Liver International
43. An Integrated Pathogenetic Model of Primary Biliary Cholangitis
    Elias Kouroumalis, Ioannis Tsomidis, Argyro Voumvouraki · 2025 · Livers
44. Laminin 511-E8, an autoantigen in IgG4-related cholangitis, contributes to cholangiocyte protection
    David C. Trampert, Remco Kersten, Dagmar Tolenaars, Aldo Jongejan, Stan F.J. van de Graaf, Ulrich H. Beuers · 2024 · JHEP Reports
45. Mechanism of formation and significance of antimitochondrial autoantibodies in the pathogenesis of primary biliary cholangitis
    Vasiliy Ivanovich Reshetnyak, Igor Veniaminovich Maev · 2024 · Exploration of Immunology
46. 34 UPREGULATION OF MIR-506 LEADS TO DECREASED AE2 EXPRESSION IN BILIARY EPITHELIUM OF PATIENTS WITH PRIMARY BILIARY CIRRHOSIS
    Jesús M. Bañales, Elena Sáez, Miriam Úriz, Patrick L. Splinter, Pamela S. Tietz Bogert, J. Prieto, J.F. Medina, Nicholas F. LaRusso · 2012 · Journal of Hepatology
47. Sekundär sklerosierende Cholangitis bei kritisch Kranken
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48. Dynamic liver preservation: Are we still missing pieces of the puzzle?
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49. Diseases of the Biliary Tree
    Pierre Russo, Elizabeth B. Rand, Kathleen M. Loomes · 2014 · Springer eBooks
50. Colangitis esclerosante secundaria en pacientes críticamente enfermos
    Carlos Alberto Peña-Pérez, Juan Alberto Díaz Ponce-Medrano · 2018 · Cirugía y Cirujanos
51. Carbonic anhydrase 14 protects the liver against the cytotoxicity of bile acids in a biliary bicarbonate umbrella-related manner
    Jiajie Qian, Qianyun Shen, Tianfang Zhang, Jing Chen, Lifeng Chen, Yang Dong, Ren Yan, Zuobing Chen · 2022 · Life Sciences
52. Physiology of Cholngiocytes
    Anatoliy I. Masyuk, Tatyana V. Masyuk, Nicholas F. LaRusso · 2018 · Elsevier eBooks
53. Current Update on Primary and Secondary Sclerosing Cholangitis
    Neeraj Lalwani, Puneet Bhargava, Kedar N. Chintapalli, Krishna Shanbhogue, Arpit M Nagar, Srinivasa R. Prasad · 2011 · Current Problems in Diagnostic Radiology
54. Therapeutic and immunological interventions in primary biliary cholangitis: from mouse models to humans
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55. Pathologic Features of Hereditary Cholestatic Diseases
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56. Cystic fibrosis liver disease in children – A review of our current understanding
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57. Opisthorchis viverrini Draft Genome – Biomedical Implications and Future Avenues
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58. Pathophysiology of Cystic Fibrosis Liver Disease
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59. Role of genetics in diagnosis and therapy of acquired liver disease
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60. Therapeutic effects of dexamethasone-loaded hyaluronan nanogels in the experimental cholestasis
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61. Bile Acids and TGR5 (Gpbar1) Signaling
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62. Evaluation of muscarinic acetylcholine receptor type 3 gene polymorphisms in patients with primary biliary cholangitis and primary sclerosing cholangitis
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63. UDCA prophylaxis for post-transplant PBC recurrence prevention: Time to change practice
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64. A beneficial response of fetal wound healing gone bad in the bile duct: The overarching cause of biliary atresia?
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65. Vascular Supply of the Bile Duct and Ischemic Cholangiopathy
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66. Proximal Extrahepatic Bile Ducts: Comprehensive Review
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67. Identification of the chloride channel, leucine‐rich repeat‐containing protein 8, subfamily a (LRRC8A), in mouse cholangiocytes
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68. Fibrosis-Related Gene Profiling in Liver Biopsies of PiZZ α1-Antitrypsin Children with Different Clinical Courses
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69. Essential roles of bile acids and their nuclear receptors, FXR and PXR, in the cholestatic liver disease
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70. New evidence supporting the biliary bicarbonate umbrella theory
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71. Fundamentals of Bicarbonate Secretion in Epithelia
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72. Cellular Homeostasis and Repair in the Biliary Tree
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73. Experimental long-term sub-normothermic machine perfusion for non-allocable human liver grafts: first data towards feasibility
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77. Cholestatic and autoimmune liver diseases, bile duct injury, oxidative stress, and therapeutic strategies
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78. Current and future opportunities for the management of primary biliary cholangitis
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79. Targeting miR-506 in primary biliary cirrhosis to support the HCO3− umbrella
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80. Pathophysiology of biochemical signs of primary biliary cholangitis
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81. Interplay of autophagy, apoptosis, and senescence in primary biliary cholangitis
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86. A HCO3-umbrella protects human cholangiocytes against bile salt-induced injury
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96. Bile Acids and Their Receptors
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