Obeticholic acid, a farnesoid X receptor agonist, improves portal hypertension by two distinct pathways in cirrhotic rats

Verbeke, Len, Farre, Ricard, Trebicka, Jonel, Komuta, Mina, Roskams, Tania, Klein, Sabine, Elst, Ingrid Vander, Windmolders, Petra +3 more·2014·Hepatology

Cited by (259)

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  5. Tailoring obeticholic acid activity by iridium(III) complex conjugation to develop a farnesoid X receptor probe
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  7. Obeticholic acid for the treatment of primary biliary cirrhosis
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  8. Evolving insights in the pathophysiology of complications of cirrhosis: The farnesoid X receptor (FXR) to the rescue?
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  9. Current and investigational drugs in early clinical development for portal hypertension
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  11. Anti-Fibrotic Therapies from Other Organs: What the Gut Can Learn from the Liver, Skin, Lung and Heart
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  13. The expanding role of the bile acid receptor farnesoid X in the intestine and its potential clinical implications
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  18. Glytan decreases portal pressureviamesentery vasoconstriction in portal hypertensive rats
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  19. Novel Targets and Drug Development in Portal Hypertension
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  20. Obeticholic acid: A new light in the shadows treating portal hypertension?
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  21. Fibrogenic Gene Signature as Early Prediction for the Efficacy of Pharmacological Interventions for MASH ‐Associated Fibrosis
    José A. Inia, Martine C. Morrison, Arianne van Koppen, Eveline Gart, Martien P. M. Caspers, Aswin L. Menke, Nicole Worms, Robert Kleemann, Lars Verschuren, J. Wouter Jukema et al. · 2025 · The FASEB Journal
  22. Stability Indicating RP-HPLC Method Development and Validation for the Quantification of Obeticholic Acid in Bulk and its Pharmaceutical Dosage Form
    R. Kiran Joythi, Kothapalli Bannoth Chandrasekhar, Balakrishnan M Balakrishnan, Badithala Siva Sai Kiran · 2020 · Indian Journal of Pharmaceutical Education and Research
  23. Novel Approaches to Reducing the Risk of Variceal Hemorrhage
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  24. Drug Discovery in Tissue Fibrosis
    S. Pinto, Maarten Hoek, Yonghong Huang, Philippe Costet, L. Ma, Jason E. Imbriglio · 2017 · Elsevier eBooks
  25. Intestinal mucus and gut-vascular barrier: FxR-modulated entry sites for pathological bacterial translocation in liver cirrhosis
    Marcel Sorribas, M. O. Jakob, B. Yilmaz, H. Li, D. Stutz, Y. Noser, Andrea De Gottardi, Sheida Moghadamrad, M. Hassan, A. Albillos et al. · 2019 · bioRxiv (Cold Spring Harbor Laboratory)
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  27. A Novel FXR-Targeted DUBTAC and Its Applications in Cholestasis Therapy
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  29. Recent advances in promising drugs for primary prevention of gastroesophageal variceal bleeding with cirrhotic portal hypertension
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  30. Role of liver sinusoidal endothelial cells in the diagnosis and treatment of liver diseases
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  31. The Gut Microbiome and Cirrhosis: Basic Aspects
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  32. Work in Progress
    Gwilym James Webb, Gideon Morris Hirschfield · 2018 · Clinics in Liver Disease
  33. Facial synthesis of key intermediate of obeticholic acid via Pd-catalyzed Kumada-Tamao-Corriu cross-coupling reaction
    Xiangjie Di, Jie Han, Sheng Zou, Xia Wei, Qingfei Huang, Jin Zhu, Yuanhua Wang, Liu Zhong, Qiwei Wang · 2020 · Steroids
  34. A New Treatment for Chronic Hepatitis B and D Offers Novel Insights Into Obesity and Hepatic Steatosis
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  35. Investigational drugs in early clinical development for portal hypertension
    Susana Gomes Rodrigues, Yuly Paulin Mendoza, Jaime Bosch · 2022 · Expert Opinion on Investigational Drugs
  36. RP-HPLC analytical method development and validation of obeticholic acid in bulk and marketed formulation
    Pawan S. Avhad, Revathi A. Gupta · 2022 · International Journal of Health Sciences
  37. Primary Biliary Cholangitis (Formerly Primary Biliary Cirrhosis)
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  38. Hepatic Circulation
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  39. Cirrhotic Portal Hypertension: New Insights in an Old Syndrome
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  40. Potential Antifibrotic Therapies: Approaching the Bedside: Proof-of-Concept Studies (Part 1)
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  41. Possible Treatment Strategies for Portal Hypertension in Liver Cirrhosis
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  42. Targeting liver inflammatory myeloid cells with immunomodulatory liposomes improves nonalcoholic steatohepatitis in mice
    Muralidhara Rao Maradana · 2016 · The University of Queensland
  43. Therapeutic Monitoring of Portal Pressure Lowering Drugs Using Liver Stiffness
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  44. Pharmacological Options for NASH
    Christiane Stern, Vlad Ratziu · 2020 · Springer eBooks
  45. Future of pharmacological treatment of non-alcoholic steatohepatitis in terms of key pathophysiological mechanisms
    Marek Rác, Ľubomír Skladaný · 2018 · Vnitřní lékařství
  46. Brief Review of Portal Hypertension Related Complications
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  47. Neue Entwicklungen in der Diagnostik und Therapie der metabolisch assoziierten, nicht-alkoholischen Fettlebererkrankung
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  50. Peripheral vasculature in portal hypertension
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  51. The liver sinusoid in chronic liver disease: NAFLD and NASH
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  52. Cirrhose métabolique : une entité en plein essor
    Vlad Ratziu · 2024 · Bulletin de l Académie Nationale de Médecine
  53. Pathophysiology of portal hypertension in liver cirrhosis
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  54. New Approaches to Alcohol-Associated Hepatitis
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  56. Role of autophagy in liver sinusoidal endothelial cells on nonalcoholic steatohepatitis
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  57. Nouveaux aspects dans la prise en charge de la cirrhose
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  58. Prise en charge chirurgicale de l’obèse et de l’obèse morbide : conséquences sur la stéatopathie métabolique et sur l’accès à la transplantation hépatique
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  59. BindingDB Entry 50008196: 7-Methylation of Chenodeoxycholic Acid Derivatives Yields a Substantial Increase in TGR5 Receptor Potency.
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