The DOI matches its Crossref record; 25 of the 25 references it cites were found in a registry or an index.
Clearance of hepatitis C infection is associated with the early appearance of broad neutralizing antibody responses
Open accessAbstract
The contribution of humoral immune responses to spontaneous control of hepatitis C virus (HCV) infection remains unclear. We assessed neutralizing antibody (nAb) responses during acute HCV infection to determine whether infection outcome is associated with the nAb response, specifically, its timing or breadth (neutralization of multiple genotype-matched variants). A representative genotype 1 HCV pseudoparticle (HCVpp) library, consisting of 19 genetically distinct genotype 1 HCVpp that comprise the natural variability of genotype 1 E1E2 sequences, was used to assess anti-genotype 1 nAb responses during acute infection in at-risk persons followed prospectively. Neutralization of individual library HCVpp by the last viremic plasma sample obtained before clearance was compared to either 1-year post-initial viremia or clearance time-matched specimens obtained from subjects developing persistent infection. In persistently infected persons nAb responses were delayed then progressively broadened, whereas in persons who controlled viremia broader responses were detected early and contracted after clearance of viremia. Surprisingly, the breadth of anti-genotype 1 nAb responses was not dependent on subjects' infection genotype. Also, individual library HCVpp neutralization sensitivity was not associated with any known E2 sequence determinants. Interestingly, two single nucleotide polymorphisms in the HLA-DQ locus were associated with nAb breadth. Conclusion: Control of HCV infection is associated with more rapid development of a broad nAb response, independent of the infection viral genotype, providing further evidence for the role of nAb in controlling HCV infection and the potential benefit of generating broad anti-HCV nAb responses by vaccination. (Hepatology 2014;59:2140–2151)
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Multiple sequence alignment with Clustal X
Jeanmougin, F., Thompson, J. D., Gouy, M., Higgins, D. G., & Gibson, T. J. (1998) · Trends in Biochemical Sciences · doi:10.1016/s0968-0004(98)01285-7 · Cited by 2,652
Clinical Outcomes after Hepatitis C Infection from Contaminated Anti-D Immune Globulin
Kenny-Walsh, E. (1999) · New England Journal of Medicine · doi:10.1056/nejm199904223401602 · Cited by 910
Genetic diversity and evolution of hepatitis C virus – 15 years on
Simmonds, P. (2004) · Journal of General Virology · doi:10.1099/vir.0.80401-0 · Cited by 865
Takaki, A., Wiese, M., Maertens, G., Depla, E., Seifert, U., Liebetrau, A., Miller, J. L., Manns, M. P., & Rehermann, B. (2000) · Nature Medicine · doi:10.1038/75063 · Cited by 739
Broadly neutralizing antibodies protect against hepatitis C virus quasispecies challenge
Law, M., Maruyama, T., Lewis, J., Giang, E., Tarr, A. W., Stamataki, Z., Gastaminza, P., Chisari, F. V., Jones, I. M., Fox, R. I., et al. (2008) · Nature Medicine · doi:10.1038/nm1698 · Cited by 591
Pestka, J. M., Zeisel, M. B., Bläser, E., Schürmann, P., Bartosch, B., Cosset, F.-L., Patel, A. H., Meisel, H., Baumert, J., Viazov, S., et al. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0607026104 · Cited by 564
The Epidemic Behavior of the Hepatitis C Virus
Pybus, O. G., Charleston, M. A., Gupta, S., Rambaut, A., Holmes, E. C., & Harvey, P. H. (2001) · Science · doi:10.1126/science.1058321 · Cited by 437
Neutralizing antibody response during acute and chronic hepatitis C virus infection
Logvinoff, C., Major, M. E., Oldach, D., Heyward, S., Talal, A., Balfe, P., Feinstone, S. M., Alter, H., Rice, C. M., & McKeating, J. A. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0403519101 · Cited by 433
CD81 Is Required for Hepatitis C Virus Glycoprotein-Mediated Viral Infection
Zhang, J., Randall, G., Higginbottom, A., Monk, P., Rice, C. M., & McKeating, J. A. (2004) · Journal of Virology · doi:10.1128/jvi.78.3.1448-1455.2004 · Cited by 361
Osburn, W. O., Fisher, B. E., Dowd, K. A., Urban, G., Liu, L., Ray, S. C., Thomas, D. L., & Cox, A. L. (2010) · Gastroenterology · doi:10.1053/j.gastro.2009.09.017 · Cited by 360
Self-citation
Cited by
Natural history of hepatitis C.
Westbrook, R. H., & Dusheiko, G. (2014) · Journal of Hepatology · doi:10.1016/j.jhep.2014.07.012 · Cited by 1,049
Immune responses and immunopathology in acute and chronic viral hepatitis
Shin, E.-C., Sung, P. S., & Park, S.-H. (2016) · Nature Reviews Immunology · doi:10.1038/nri.2016.69 · Cited by 365
HCV-Specific T Cell Responses During and After Chronic HCV Infection
Luxenburger, H., Neumann-Haefelin, C., Thimme, R., & Boettler, T. (2018) · Viruses · doi:10.3390/v10110645 · Cited by 64
Capella-Pujol, J., de Gast, M., Radić, L., Zon, I., Chumbe, A., Koekkoek, S., Olijhoek, W., Schinkel, J., van Gils, M. J., Sanders, R. W., et al. (2023) · Nature Communications · doi:10.1038/s41467-023-39690-0 · Cited by 12
Metadata
- Authors
- Osburn, W. O., Snider, A. E., Wells, B. L., Latanich, R., Bailey, J. R., Thomas, D. L., Cox, A. L., & Ray, S. C.
- Venue
- Hepatology
- Published
- 2014-06
- Volume
- 59
- Issue
- 6
- Pages
- 2140-2151
- ISSN
- 0270-9139 (ISSN-L)
- OpenAlex
- W1569603086
- Cited by
- 272
- References
- 25
- FWCI
- 13.43
- Type
- journal article
- Language
- en
- Open access
- bronze
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
How to cite
Cite CoChat for the checks on this page, and the paper for its own findings.
- This page
- CoChat. (2026). Citation check: Clearance of hepatitis C infection is associated with the early appearance of broad neutralizing antibody responses. https://app.cochat.ai/papers/10.1002/hep.27013
- The paper
- Osburn, W. O., Snider, A. E., Wells, B. L., Latanich, R., Bailey, J. R., Thomas, D. L., Cox, A. L., & Ray, S. C. (2014). Clearance of hepatitis C infection is associated with the early appearance of broad neutralizing antibody responses. Hepatology. https://doi.org/10.1002/hep.27013
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
