The DOI matches its Crossref record; 30 of the 30 references it cites were found in a registry or an index.
Hepatitis C virus drug resistance–associated substitutions: State of the art summary
Open accessAbstract
Hepatitis C virus (HCV) drug development has resulted in treatment regimens composed of interferon‐free, all‐oral combinations of direct‐acting antivirals. While the new regimens are potent and highly efficacious, the full clinical impact of HCV drug resistance, its implications for retreatment, and the potential role of baseline resistance testing remain critical research and clinical questions. In this report, we discuss the viral proteins targeted by HCV direct‐acting antivirals and summarize clinically relevant resistance data for compounds that have been approved or are currently in phase 3 clinical trials. Conclusion : This report provides a comprehensive, systematic review of all resistance information available from sponsors’ trials as a tool to inform the HCV drug development field. (H epatology 2015;62:1623–1632)
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Cites
Hepatitis C Viral Dynamics in Vivo and the Antiviral Efficacy of Interferon-α Therapy
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Ledipasvir and Sofosbuvir for Untreated HCV Genotype 1 Infection
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Self-citationMansky, L. M., & Temin, H. M. (1995) · Journal of Virology · doi:10.1128/jvi.69.8.5087-5094.1995 · Cited by 1,154
Chemical genetics strategy identifies an HCV NS5A inhibitor with a potent clinical effect
Gao, M., Nettles, R. E., Belema, M., Snyder, L. B., Nguyen, V. N., Fridell, R. A., Serrano-Wu, M. H., Langley, D. R., Sun, J.-H., O’Boyle II, D. R., et al. (2010) · Nature · doi:10.1038/nature08960 · Cited by 939
Treatment of HCV with ABT-450/r–Ombitasvir and Dasabuvir with Ribavirin
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Self-citationABT-450/r–Ombitasvir and Dasabuvir with Ribavirin for Hepatitis C with Cirrhosis
Poordad, F., Hezode, C., Trinh, R., Kowdley, K. V., Zeuzem, S., Agarwal, K., Shiffman, M. L., Wedemeyer, H., Berg, T., Yoshida, E. M., et al. (2014) · New England Journal of Medicine · doi:10.1056/nejmoa1402869 · Cited by 874
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Sofosbuvir and Ribavirin in HCV Genotypes 2 and 3
Zeuzem, S., Dusheiko, G. M., Salupere, R., Mangia, A., Flisiak, R., Hyland, R. H., Illeperuma, A., Svarovskaia, E., Brainard, D. M., Symonds, W. T., et al. (2014) · New England Journal of Medicine · doi:10.1056/nejmoa1316145 · Cited by 795
Nucleotide Polymerase Inhibitor Sofosbuvir plus Ribavirin for Hepatitis C
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Self-citation
Cited by
Hepatitis C virus NS3/4a protease inhibitors
McCauley, J. A., & Rudd, M. T. (2016) · Current Opinion in Pharmacology · doi:10.1016/j.coph.2016.07.015 · Cited by 120
Metadata
- Authors
- Lontok, E., Harrington, P., Howe, A., Kieffer, T., Lennerstrand, J., Lenz, O., McPhee, F., Mo, H., Parkin, N., Pilot‐Matias, T., & Miller, V.
- Venue
- Hepatology
- Published
- 2015-07-30
- Volume
- 62
- Issue
- 5
- Pages
- 1623-1632
- ISSN
- 0270-9139 (ISSN-L)
- 1527-3350
- OpenAlex
- W1826210767
- Cited by
- 275
- References
- 30
- FWCI
- 28.14
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- Lontok, E., Harrington, P., Howe, A., Kieffer, T., Lennerstrand, J., Lenz, O., McPhee, F., Mo, H., Parkin, N., Pilot‐Matias, T., & Miller, V. (2015). Hepatitis C virus drug resistance–associated substitutions: State of the art summary. Hepatology. https://doi.org/10.1002/hep.27934
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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