Depletion of B cells induces remission of autoimmune hepatitis in mice through reduced antigen presentation and help to T cells

Béland, Kathie; Marceau, Gabriel; Labardy, Agathe; Bourbonnais, Sara; Alvarez, Fernando

doi:10.1002/hep.27991

Depletion of B cells induces remission of autoimmune hepatitis in mice through reduced antigen presentation and help to T cells

Unlabelled Autoimmune hepatitis (AIH) is known as a T cell-mediated disease. However, AIH patients refractory to conventional treatment have been successfully treated with anti-CD20-mediated B-cell depletion. The aim of this project was to understand the immunological changes underlying the AIH r…