The origin of fibrogenic myofibroblasts in fibrotic liver
Open accessAbstract
Liver fibrosis results from chronic liver injury of different etiologies. It is characterized by dysregulation of physiological remodeling, activation of myofibroblasts, and formation of a fibrous scar. Myofibroblasts develop contractile functions and secrete the extracellular matrix proteins that form this fibrous scar. Myofibroblasts are not present in the normal liver but activate and proliferate in response to injury and inflammation. This review summarizes the understanding and controversies on the contribution of cell populations to the myofibroblasts in liver fibrosis. (H epatology 2017;65:1039‐1043).
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HSCs are the principal precursor cells that transdifferentiate into αSMA-expressing myofibroblast-like fibrogenic cells following liver injury.
“hepatic stellate cells (HSCs) are the principal precursor cells that undergo “activation” and transdifferentiate into alpha smooth muscle actin (αSMA)‐expressing myofibroblast‐like fibrogenic cells following liver injury”
From Cellular communication network factor 1‐stimulated liver macrophage efferocytosis drives hepatic stellate cell activation and liver fibrosis (2022) · cites this paper as [3]
The HSCs section says hepatic stellate cells are the predominant origin of myofibroblasts in most types of experimental liver disease and acquire a myofibroblast phenotype when activated. The Abstract identifies αSMA expression as a widely used myofibroblast marker. The unqualified reference to liver injury is broader than the source’s finding: the Conclusions identify portal fibroblasts as contributors in early cholestatic injury. (LLM, conf=0.84)
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References 21 · Cited by 224
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- Authors
- Kisseleva, T.
- Affiliations
- University of California San Diego (US)
- Corresponding author
- Kisseleva, Tatiana
- ORCID
- Kisseleva, Tatiana
- Venue
- Hepatology
- Published
- 2017-01-11
- Volume
- 65
- Issue
- 3
- Pages
- 1039-1043
- ISSN
- 0270-9139 (ISSN-L)
- 1527-3350
- PMC
- PMC5476301
- OpenAlex
- W2551553748
- Cited by
- 224
- References
- 21
- Citations by year
- 2026: 10 · 2025: 21 · 2024: 20 · 2023: 29 · 2022: 33 · 2021: 26 · 2020: 28 · 2019: 26 · 2018: 21 · 2017: 10
- FWCI
- 13.74
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Hepatology (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institutes of Health (AA022614)
- National Institute on Alcohol Abuse and Alcoholism (U01AA022614)
- National Institute of Diabetes and Digestive and Kidney Diseases (R01DK111866, R01DK101737, R01DK099205)
- Topics
- Health Sciences › Medicine › Hepatology › Liver physiology and pathology
- Health Sciences › Medicine › Epidemiology › Liver Disease Diagnosis and Treatment
- Health Sciences › Medicine › Hepatology › Liver Diseases and Immunity
- Keywords
- liver fibrosis, myofibroblasts, fibrogenesis, myofibroblast origin, extracellular matrix, chronic liver injury, inflammation, tissue remodeling, fibrotic scar
- MeSH terms
- Animals, Cell Differentiation, Cells, Cultured, Epithelium, Extracellular Matrix, Humans, Liver Cirrhosis, Sensitivity and Specificity, Cell Proliferation, Hepatic Stellate Cells, Myofibroblasts
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