Sphingosine‐1‐phosphate promotes tumor development and liver fibrosis in mouse model of congestive hepatopathy

Kawai, Hironari; Osawa, Yosuke; Matsuda, Michitaka; Tsunoda, Tomoyuki; Yanagida, Keisuke; Hishikawa, Daisuke; Okawara, Miku; Sakamoto, Yuzuru; Shimagaki, Tomonari; Tsutsui, Yuriko; Yoshida, Yuichi; Yoshikawa, Shiori; Hashi, Kana; Doi, Hiroyoshi; Mori, Taizo; Yamazoe, Taiji; Yoshio, Sachiyo; Sugiyama, Masaya; Okuzaki, Daisuke; Komatsu, Haruki; Inui, Ayano; Tamura‐Nakano, Miwa; Oyama, Chinatsu; Shindou, Hideo; Kusano, Hironori; Kage, Masayoshi; Ikegami, Toru; Yanaga, Katsuhiko; Kanto, Tatsuya

doi:10.1002/hep.32256

Sphingosine‐1‐phosphate promotes tumor development and liver fibrosis in mouse model of congestive hepatopathy

Background and Aims Chronic liver congestion reflecting right‐sided heart failure (RHF), Budd‐Chiari syndrome, or Fontan‐associated liver disease (FALD) is involved in liver fibrosis and HCC. However, molecular mechanisms of fibrosis and HCC in chronic liver congestion remain poorly understood. A…