Combinatorial targeting of G‐protein‐coupled bile acid receptor 1 and cysteinyl leukotriene receptor 1 reveals a mechanistic role for bile acids and leukotrienes in drug‐induced liver injury

Biagioli, Michele; Marchianò, Silvia; di Giorgio, Cristina; Roselli, Rosalinda; Bordoni, Martina; Bellini, Rachele; Fiorillo, Bianca; Sepe, Valentina; Catalanotti, Bruno; Cassiano, Chiara; Monti, Maria Chiara; Distrutti, Eleonora; Zampella, Angela; Fiorucci, Stefano

doi:10.1002/hep.32787

Combinatorial targeting of G‐protein‐coupled bile acid receptor 1 and cysteinyl leukotriene receptor 1 reveals a mechanistic role for bile acids and leukotrienes in drug‐induced liver injury

Background and Aim: Drug‐induced liver injury (DILI) is a common disorder that involves both direct liver cell toxicity and immune activation. The bile acid receptor, G‐protein‐coupled bile acid receptor 1 (GPBAR1; Takeda G‐protein‐coupled receptor 5 [TGR5]), and cysteinyl leukotriene receptor (C…