Drug‐induced cholestasis
Open accessAbstract
Cholestatic drug‐induced liver injury (DILI) can be a diagnostic challenge due to a large differential diagnosis, variability in clinical presentation, and lack of serologic biomarkers associated with this condition. The clinical presentation of drug‐induced cholestasis includes bland cholestasis, cholestatic hepatitis, secondary sclerosing cholangitis, and vanishing bile duct syndrome. The associate mortality of cholestatic DILI can be as high as 10%, and thus prompt recognition and removal of the offending agent is of critical importance. Several risk factors have been identified for drug‐induced cholestasis, including older age, genetic determinants, and properties of certain medications. Antibiotics, particularly amoxicillin/clavulanate, remain the predominant cause of cholestatic DILI, although a variety of other medications associated with this condition have been identified. In this review, we summarize the presentation, clinical approach, risk factors, implicated medications, and management of drug‐induced cholestatic liver injury. (Hepatology Communications 2017;1:726–735)
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Antibiotics can induce chronic cholestasis and DILI.
“Although these antibiotic-based treatments have transient benefits in cholestasis patients, antibiotics can induce chronic cholestasis and DILI (reviewed in22).”
From Cholestasis induced by bile duct ligation promotes changes in the intestinal microbiome in mice (2019) · cites this paper as [22]
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References 155 · Cited by 138
- Authors
- Sundaram, V., & Björnsson, E. S.
- Affiliations
- Cedars-Sinai Medical Center (US)
- Section of Gastroenterology and Hepatology, Department of Internal Medicine,National University Hospital of Iceland,Reykjavík,Iceland
- Corresponding author
- Sundaram, Vinay
- ORCID
- Sundaram, Vinay
- Venue
- Hepatology Communications
- Published
- 2017-09-11
- Volume
- 1
- Issue
- 8
- Pages
- 726-735
- ISSN
- 2471-254X (ISSN-L)
- PMC
- PMC5678916
- OpenAlex
- W2040034538
- Cited by
- 138
- References
- 155
- Citations by year
- 2026: 11 · 2025: 18 · 2024: 16 · 2023: 13 · 2022: 15 · 2021: 20 · 2020: 22 · 2019: 12 · 2018: 5 · 2016: 1 · 2014: 2 · 2013: 2
- FWCI
- 1.86
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- Hepatology Communications (publishedVersion, cc-by-nc-nd)
- Europe PMC (PubMed Central) (publishedVersion, cc-by-nc-nd)
- PubMed Central (publishedVersion, cc-by-nc-nd)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Hirsla (Landspítali University Hospital) (submittedVersion)
- Topics
- Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmacology › Drug-Induced Hepatotoxicity and Protection
- Health Sciences › Medicine › Hepatology › Liver Diseases and Immunity
- Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Toxicology › Pharmacovigilance and Adverse Drug Reactions
- Keywords
- drug-induced liver injury, cholestatic liver injury, cholestasis, cholestatic hepatitis, secondary sclerosing cholangitis, vanishing bile duct syndrome, amoxicillin-clavulanic acid, antibiotics, risk factors, pharmaceutical removal
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