GluR5,6,7 subunit immunoreactivity on apical pyramidal cell dendrites in hippocampus of schizophrenics and manic depressives
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Recent postmortem studies have suggested that changes in the regulation of kainate-sensitive glutamate receptors (kainate receptors) in the hippocampus may play a role in schizophrenia. To explore this possibility further, the distribution of immunoreactivity (IR) for the GluR5,6,7 subunits of the KR was assessed in a cohort consisting of 15 normal controls, 15 schizophrenics, and 9 manic depressives matched for age and postmortem interval (PMI). Cross sections of hippocampus showed abundant GluR5,6,7-IR on apical dendrites of pyramidal neurons in the stratum radiatum and stratum moleculare. In normal controls, both the numerical and length density of IR dendrites were much higher in sector CA2 than in sectors CA3 or CA1. When data for the individual groups were separately examined, the schizophrenics showed a 30-35% reduction in the density of GluR5,6,7-IR dendrites found in both stratum radiatum and stratum moleculare of sectors CA3 and CA2, as well as proximal and middle portions of CA1. In CA2, the magnitude of this decrease in schizophrenia was 2.5 times larger than that seen in any of the other sectors. For the manic depressive group, no significant differences were observed in any sectors or laminae examined. The potential confounding effects of either age, PMI, or neuroleptic exposure do not explain the reduced density of IR dendrites detected in the schizophrenic group. Taken together, the preferential reduction of GluR5,6,7-IR observed on apical dendrites of pyramidal neurons is consistent with a functional downregulation of the kainate receptor in the hippocampus of schizophrenic brain.
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Schizophrenics express significantly reduced kainate receptors in the hippocampus.
“and schizophrenics have been found express significantly reduced kainate receptors in this region (Hunter et al., 2009;Benes et al., 2001).”
From Glutamate receptors in domestication and modern human evolution (2020) · cites this paper as Benes et al., 2001
High glucocorticoid inputs from the adrenal gland to the hippocampus reduce the expression of kainate receptors.
“Furthermore, high glucocorticoid inputs from the adrenal gland to the hippocampus reduce the expression of kainate receptors, and schizophrenics have been found express significantly reduced kainate receptors in this region (Hunter et al., 2009;Benes et al., 2001).”
From Glutamate receptors in domestication and modern human evolution (2020) · cites this paper as Benes et al., 2001
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References 52 · Cited by 79
Research works printed but not linked: 1
- Amaral DG, Price JL, Pitka ¨nen A, Carmichael ST. Anatomical organiza- tion of the primate amygdaloid complex. In: Aggleton JP, editor. Amygdala. New York: Wiley-Liss; 1992. p 1-66.
- Authors
- Benes, F. M., Todtenkopf, M. S., & Kostoulakos, P.
- Affiliations
- Harvard University (US)
- Corresponding author
- Benes, Francine M.
- Venue
- Hippocampus
- Publisher
- Wiley
- Published
- 2001-10
- Volume
- 11
- Issue
- 5
- Pages
- 482-491
- ISSN
- 1050-9631 (ISSN-L)
- 1098-1063
- OpenAlex
- W1970761153
- Cited by
- 79
- References
- 52
- Citations by year
- 2025: 2 · 2023: 4 · 2022: 2 · 2021: 2 · 2019: 2 · 2018: 1 · 2017: 1 · 2016: 3 · 2015: 2 · 2014: 3 · 2013: 3 · 2012: 3
- FWCI
- 1.84
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Hippocampus (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institute of Mental Health (MH.NS 31862, MH-42261, MH00423)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Health Sciences › Medicine › Psychiatry and Mental health › Schizophrenia research and treatment
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Amino Acid Enzymes and Metabolism
- Keywords
- kainate receptors, glutamate receptors, schizophrenia, bipolar disorder, apical dendrites, pyramidal neurons, receptor down-regulation, postmortem brain, CA2, CA3, CA1, stratum radiatum, stratum moleculare
- MeSH terms
- GluK2 Kainate Receptor, GluK3 Kainate Receptor, Adult, Aged, Aged, 80 and over, Bipolar Disorder, Dendrites, gamma-Aminobutyric Acid, Hippocampus, Humans, Middle Aged, Neural Pathways, Schizophrenia, Pyramidal Cells, Kainic Acid Receptors
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