Adrenalectomy‐induced granule cell degeneration in the hippocampus causes spatial memory deficits that are not reversed by chronic treatment with corticosterone or fluoxetine
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Long‐term adrenalectomy (ADX) causes a nearly complete and selective loss of granule cells in the dentate gyrus (DG) of the hippocampus. Previously, learning and memory deficits have been observed following ADX‐induced granule cell degeneration for tasks that require the hippocampus. Our objective here was to determine whether corticosterone (CORT) replacement and treatment with the neurogenic compound fluoxetine could reverse behavioral deficits after ADX. We trained ADX and control rats in a moving, hidden platform version of the Morris water task before chronic administration (6 weeks) of CORT and either fluoxetine or vehicle. After treatment, all rats were retested in the Morris water task. Brains were labeled for the endogenous neurogenic markers Ki67 and doublecortin. Here we provide evidence that neurogenesis persists at a normal rate in the hippocampus after long‐term ADX. After 8 weeks of CORT and fluoxetine administration, ADX‐fluoxetine rats did not differ significantly compared to ADX‐vehicle rats receiving CORT or compared to control rats in the number of Ki67 or doublecortin labeled cells. ADX‐fluoxetine rats also did not significantly differ from ADX‐vehicle rats in regards to granule cell layer thickness. Our results indicate that long‐term ADX is associated with impaired spatial ability in the Morris water task and that neither chronic treatment with CORT, nor with CORT and fluoxetine are capable of altering the Morris water task deficit. © 2006 Wiley‐Liss, Inc.
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Damage of any part of the hippocampal circuit affects learning and memory.
“Damage of any part of this circuit will affect the process of learning and memory30313233.”
From Early developmental bisphenol-A exposure sex-independently impairs spatial memory by remodeling hippocampal dendritic architecture and synaptic transmission in rats (2016) · cites this paper as [31]
The Discussion (page unavailable) says dentate gyrus integrity is critical for spatial learning in rats and reports impaired spatial-learning performance after selective damage. It does not establish that damage to any part of the hippocampal circuit affects learning and memory generally. (LLM, conf=0.86)
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References 45 · Cited by 39
Research works printed but not linked: 1
- Rudy JW, Barrientos RM, O'Reilly RC. 2002. The hippocampal for- mation supports conditioning to memory of a context. Behav Neu- rosci 116:530-538.
- Authors
- Spanswick, S. C., Epp, J. R., Keith, J. R., & Sutherland, R. J.
- Affiliations
- University of Lethbridge (CA)
- University of North Carolina Wilmington (US)
- Corresponding author
- Sutherland, Robert J.
- Venue
- Hippocampus
- Publisher
- Wiley
- Published
- 2006-12-20
- Volume
- 17
- Issue
- 2
- Pages
- 137-146
- ISSN
- 1050-9631 (ISSN-L)
- 1098-1063
- OpenAlex
- W2080428271
- Cited by
- 39
- References
- 45
- Citations by year
- 2022: 2 · 2021: 1 · 2020: 3 · 2018: 1 · 2017: 3 · 2016: 1 · 2015: 3 · 2014: 1 · 2013: 3 · 2012: 1
- FWCI
- 1.78
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Hippocampus (publishedVersion)
- PubMed (publishedVersion)
- Funders
- University of Lethbridge
- Fondation pour la Recherche Médicale
- Alberta Heritage Foundation for Medical Research
- National Institutes of Health
- Canadian Institutes of Health Research (200409MOP)
- National Institute of Mental Health (R01MH061460, MH061460)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
- Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
- Keywords
- adrenalectomy, dentate gyrus, spatial memory impairment, corticosterone replacement, fluoxetine, hippocampal neurogenesis, Ki-67, doublecortin, Morris water task, glucocorticoid withdrawal, neurogenesis
- MeSH terms
- Doublecortin Domain Proteins, Doublecortin Protein, Adrenalectomy, Animals, Cell Count, Corticosterone, Cytoplasmic Granules, Fluoxetine, Hippocampus, Immunohistochemistry, Male, Memory Disorders, Microtubule-Associated Proteins, Nerve Degeneration, Neuropeptides, Space Perception, Biomarkers, Selective Serotonin Reuptake Inhibitors, Maze Learning, Ki-67 Antigen, Rats, Long-Evans, Rats
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