Parvalbumin interneuron mediated feedforward inhibition controls signal output in the deep layers of the perirhinal-entorhinal cortex
Open accessAbstract
The perirhinal (PER) and lateral entorhinal (LEC) cortex form an anatomical link between the neocortex and the hippocampus. However, neocortical activity is transmitted through the PER and LEC to the hippocampus with a low probability, suggesting the involvement of the inhibitory network. This study explored the role of interneuron mediated inhibition, activated by electrical stimulation in the agranular insular cortex (AiP), in the deep layers of the PER and LEC. Activated synaptic input by AiP stimulation rarely evoked action potentials in the PER-LEC deep layer excitatory principal neurons, most probably because the evoked synaptic response consisted of a small excitatory and large inhibitory conductance. Furthermore, parvalbumin positive (PV) interneurons-a subset of interneurons projecting onto the axo-somatic region of principal neurons-received synaptic input earlier than principal neurons, suggesting recruitment of feedforward inhibition. This synaptic input in PV interneurons evoked varying trains of action potentials, explaining the fast rising, long lasting synaptic inhibition received by deep layer principal neurons. Altogether, the excitatory input from the AiP onto deep layer principal neurons is overruled by strong feedforward inhibition. PV interneurons, with their fast, extensive stimulus-evoked firing, are able to deliver this fast evoked inhibition in principal neurons. This indicates an essential role for PV interneurons in the gating mechanism of the PER-LEC network.
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Projections from the perirhinal cortex to LEC and those from the postrhinal cortex to MEC are functionally different, with the former primarily sending inhibitory signals and the latter primarily sending excitatory ones.
“Projections from the perirhinal cortex to LEC and those from the postrhinal cortex to MEC are functionally different, with the former primarily sending inhibitory signals (Apergis-Schoute et al., 2007; Pinto et al., 2006; Willems et al., 2018) and the latter primarily sending excitatory ones (Koganezawa et al., 2015).”
From The medial prefrontal cortex - hippocampus circuit that integrates information of object, place and time to construct episodic memory in rodents: Behavioral, anatomical and neurochemical properties (2020) · cites this paper as Willems et al., 2018
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References 64 · Cited by 25
- Authors
- Willems, J. G. P., Wadman, W. J., & Cappaert, N. L. M.
- Affiliations
- University of Amsterdam (NL)
- Corresponding author
- Cappaert, Natalie L. M.
- Venue
- Hippocampus
- Publisher
- Wiley
- Published
- 2018-01-27
- Volume
- 28
- Issue
- 4
- Pages
- 281-296
- ISSN
- 1050-9631 (ISSN-L)
- 1098-1063
- PMC
- PMC5900730
- OpenAlex
- W2791311505
- Cited by
- 25
- References
- 64
- Citations by year
- 2026: 3 · 2025: 1 · 2024: 2 · 2023: 1 · 2022: 3 · 2021: 6 · 2020: 3 · 2019: 5 · 2018: 1
- FWCI
- 2.23
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Hippocampus (publishedVersion, cc-by-nc)
- Europe PMC (PubMed Central) (publishedVersion, other-oa)
- PubMed Central (publishedVersion, cc-by-nc)
- PubMed (publishedVersion)
- UvA-DARE (University of Amsterdam) (submittedVersion, cc-by-nc)
- Data Archiving and Networked Services (DANS) (submittedVersion, other-oa)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural dynamics and brain function
- Keywords
- parvalbumin interneurons, feedforward inhibition, perirhinal cortex, lateral entorhinal cortex, agranular insular cortex, synaptic inhibition, signal gating
- MeSH terms
- Perirhinal Cortex, Action Potentials, Animals, Female, Interneurons, Male, Mice, Inbred C57BL, Mice, Transgenic, Neural Inhibition, Parvalbumins, Synapses, Pyramidal Cells, Patch-Clamp Techniques, Entorhinal Cortex, Feedback, Physiological, Tissue Culture Techniques
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