The DOI matches its Crossref record; 3 of the 3 references it cites were found in a registry or an index.
Cyclosporin A, ein immunsuppressiv wirksamer Peptidmetabolit aus Trichoderma polysporum (L INK ex P ERS.) Rifai
Abstract
Cyclosporin A, a Peptide Metabolite from Trichoderma polysporum (L INK ex P ERS.) Rifai, with a remarkable immunosuppressive activity Two antifungal metabolites, cyclosporins A and C, were isolated from a strain of Trichoderma polysporum (L INK ex P ERS.) Rifai. Cyclosporin A, the main component, has the molecular formula C 62 H 111 N 11 O 12 as deduced by NMR. and mass spectra. Hydrolytic cleavage of cyclosporin A furnished 11 amino acids as fragments, among them an artefact of a new C 9‐amino acid. The amino acid sequence was determined by Edman degradation of iso‐cyclosporin A, a basic rearrangement product formed from cyclosporin A by N, O‐acyl migration. In an independent investigation an X‐ray analysis of the iodo derivative 10 was performed (see the following paper). On the basis of the chemical, spectroscopic and crystallographic evidence the complete structure of cyclosporin A was elucidated as the neutral cyclic oligopeptide 1. Cyclosporin A and C show remarkable immunosuppressive and antiphlogistic activities in several pharmacological models.
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Citations
Cites
CHROMATOGRAPHY OF AMINO ACIDS ON SULFONATED POLYSTYRENE RESINS
Moore, S., & Stein, W. H. (1951) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)77791-6 · Cited by 1,768
Crystal and Molecular Structure of an Iodo‐derivative of the Cyclic Undecapeptide Cyclosporin A
Petcher, T. J., Weber, H., & Rüegger, A. (1976) · Helvetica Chimica Acta · doi:10.1002/hlca.19760590509 · Cited by 214
Self-citationIsolierung und Strukturaufklärung von Chlamydocin
Closse, A., & Huguenin, R. (1974) · Helvetica Chimica Acta · doi:10.1002/hlca.19740570306 · Cited by 190
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Modulators of Protein–Protein Interactions
Milroy, L.-G., Grossmann, T. N., Hennig, S., Brunsveld, L., & Ottmann, C. (2014) · Chemical Reviews · doi:10.1021/cr400698c · Cited by 497
Bedir, M., Outwin, E., Colnaghi, R., Bassett, L., Abramowicz, I., & O’Driscoll, M. (2024) · EMBO Reports · doi:10.1038/s44319-024-00184-9 · Cited by 6
Metadata
- Authors
- Rüegger, A., Kuhn, M., Lichti, H., Loosli, H., Huguenin, R., Quiquerez, C., & von Wartburg, A.
- Venue
- Helvetica Chimica Acta
- Publisher
- Wiley
- Published
- 1976-06-02
- Volume
- 59
- Issue
- 4
- Pages
- 1075-1092
- ISSN
- 0018-019X (ISSN-L)
- 1522-2675
- OpenAlex
- W2078267612
- Cited by
- 384
- References
- 3
- FWCI
- 6.05
- Type
- journal article
- Language
- en
- Open access
- closed
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- The paper
- Rüegger, A., Kuhn, M., Lichti, H., Loosli, H., Huguenin, R., Quiquerez, C., & von Wartburg, A. (1976). Cyclosporin A, ein immunsuppressiv wirksamer Peptidmetabolit aus Trichoderma polysporum (L INK ex P ERS.) Rifai. Helvetica Chimica Acta. https://doi.org/10.1002/hlca.19760590412
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