The DOI matches its Crossref record; 15 of the 15 references it cites were found in a registry or an index.
Growth fractions in malignant non‐Hodgkin's lymphomas (NHL) as determined in situ with the monoclonal antibody Ki‐67
Abstract
The proportion of proliferating cells in malignant non‐Hodgkin's lymphomas (NHL) was determined in situ by immunostaining with the monoclonal antibody Ki‐67, which reacts with a nuclear antigen that is present only in proliferating cells. A highly significant correlation could be demonstrated between the proportion of Ki‐67 positive cells and the classification into high and low‐grade NHL according to the Kiel classification. 93·8 per cent of high‐grade and 88·5 per cent of low‐grade malignancies were correctly allocated to these groups using the percentage of Ki‐67 positive cells as discriminant parameter. On the basis of the medians, the degree of proliferation also paralleled the succession of entities within the Kiel classification. Within most of these different entities, however, the ranges of Ki‐67 positive cells varied considerably, indicating that the growth fractions within these groups are rather heterogeneous. Thus it might be useful to determine the growth fraction of each individual case of NHL, because this might be of prognostic value.
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Cites
Gerdes, J., Lemke, H., Baisch, H., Wacker, H. H., Schwab, U., & Stein, H. (1984) · The Journal of Immunology · doi:10.4049/jimmunol.133.4.1710 · Cited by 4,173
Self-citationThe Non-Hodgkin's Lymphoma Pathologic Classification Project (1982) · Cancer · doi:10.1002/1097-0142(19820515)49:10<2112::aid-cncr2820491024>3.0.co;2-2 · Cited by 3,059
Gerdes, J., Schwab, U., Lemke, H., & Stein, H. (1983) · International Journal of Cancer · doi:10.1002/ijc.2910310104 · Cited by 2,788
Self-citationReinherz, E. L., Kung, P. C., Goldstein, G., Levey, R. H., & Schlossman, S. F. (1980) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.77.3.1588 · Cited by 1,630
Immunologic characterization of human malignant lymphomas
Lukes, R. J., & Collins, R. D. (1974) · Cancer · doi:10.1002/1097-0142(197410)34:8+<1488::aid-cncr2820340822>3.0.co;2-c · Cited by 1,092
CLASSIFICATION OF NON-HODGKIN'S LYMPHOMAS
Bennett, M., Farrer-Brown, G., Henry, K., Jelliffe, A. M., Gerard-Marchant, R., Hamlin, I., Lennert, K., Rilke, F., Stansfeld, A. G., & Van Unnik, J. A. M. (1974) · The Lancet · doi:10.1016/s0140-6736(74)91786-3 · Cited by 555
Self-citationImmunohistologic analysis of the organization of normal lymphoid tissue and non-Hodgkin's lymphomas.
Stein, H., Bonk, A., Tolksdorf, G., Lennert, K., Rodt, H., & Gerdes, J. (1980) · Journal of Histochemistry & Cytochemistry · doi:10.1177/28.8.7003001 · Cited by 431
Self-citationStein, H., Gerdes, J., Schwab, U., Lemke, H., Mason, D. Y., Ziegler, A., Schienle, W., & Diehl, V. (1982) · International Journal of Cancer · doi:10.1002/ijc.2910300411 · Cited by 418
Self-citation3 The normal and malignant germinal centre
Stein, H., Gerdes, J., & Mason, D. Y. (1982) · Clinics in Haematology · doi:10.1016/s0308-2261(82)80005-2 · Cited by 370
Self-citation(1984) · Advances in Cancer Research · doi:10.1016/s0065-230x(08)60456-x · Cited by 261
Cited by
Edakuni, G., Sasatomi, E., Satoh, T., Tokunaga, O., & Miyazaki, K. (2001) · Pathology International · doi:10.1046/j.1440-1827.2001.01182.x · Cited by 130
Platelet-Derived Growth Factor Promotes Repair of Chronically Demyelinated White Matter
Vana, A. C., Flint, N. C., Harwood, N. E., Le, T. Q., Fruttiger, M., & Armstrong, R. C. (2007) · Journal of Neuropathology & Experimental Neurology · doi:10.1097/nen.0b013e3181587d46 · Cited by 101
Metadata
- Authors
- Gerdes, J., Dallenbach, F., Lennert, K., Lemke, H., & Stein, H.
- Venue
- Hematological Oncology
- Publisher
- Wiley
- Published
- 1984-10
- Volume
- 2
- Issue
- 4
- Pages
- 365-371
- ISSN
- 0278-0232 (ISSN-L)
- 1099-1069
- OpenAlex
- W2065002439
- Cited by
- 313
- References
- 15
- FWCI
- 9.17
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: Growth fractions in malignant non‐Hodgkin's lymphomas (NHL) as determined in situ with the monoclonal antibody Ki‐67. https://app.cochat.ai/papers/10.1002/hon.2900020406
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- Gerdes, J., Dallenbach, F., Lennert, K., Lemke, H., & Stein, H. (1984). Growth fractions in malignant non‐Hodgkin's lymphomas (NHL) as determined in situ with the monoclonal antibody Ki‐67. Hematological Oncology. https://doi.org/10.1002/hon.2900020406
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
