Oxytocin interference in the effects induced by inhalation of 7.5% CO2 in healthy volunteers
Abstract
Objective: The objective of this study was to assess the acute effect of intranasally administered oxytocin (OT) on subjective states, cardiovascular, and endocrine parameters in healthy volunteers who inhaled 7.5% CO 2. Methods: Forty‐five subjects were allocated into three matched groups of subjects who received 24 international units (IU) of OT, 2 mg of lorazepam (LZP), or placebo (PL). The challenge consisted of medical air inhalation for 20 min, 10 min of rest, and CO 2 7.5% inhalation for 20 min. Subjective effects were evaluated by self‐assessment scales; heart rate, blood pressure, skin conductance, and salivary cortisol were also measured. Assessments were performed at four time points: (i) baseline (−15 min); (ii) post‐air inhalation (90 min); (iii) post‐CO 2 inhalation (120 min), and (iv) post‐test (160 min). Results: CO 2 inhalation significantly increased the anxiety score in the PL group compared with the post‐air measurement but not in the OT or LZP groups. The LZP reduced anxiety after medical air inhalation. Other parameters evaluated were not affected by OT. Conclusion: OT, as well as LZP, prevented CO 2‐induced anxiety, suggesting that this hormone has anxiolytic properties. Copyright © 2012 John Wiley & Sons, Ltd.
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A review of human studies suggests that oxytocin may exert both anxiogenic and anxiolytic effects, depending on individual and context variables, which are not always reflected in changes in cortisol levels.
“a review of human studies examining the effect of oxytocin on cortisol suggests that oxytocin may exert both anxiogenic and anxiolytic effects, depending on a variety of individual and context variables 77, 78, which are not always reflected in changes in cortisol levels 79, 80.”
From The Analgesic Effect of Oxytocin in Humans: A Double‐Blind, Placebo‐Controlled Cross‐Over Study Using Laser‐Evoked Potentials (2016) · cites this paper as [79]
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References 43 · Cited by 39
- Authors
- de Oliveira, D. C. G., Chagas, M. H. N., Garcia, L. V., Crippa, J. A. S., & Zuardi, A. W.
- Affiliations
- Department of Neuroscience and Behavior, Faculty of Medicine of Ribeirão Preto, and National Institute for Translacional Medicine (INCT‐TM, CNPq) University of São Paulo Ribeirão Preto Brazil
- Conselho Nacional de Desenvolvimento Científico e Tecnológico (BR)
- Discipline of Anesthesiology, Faculty of Medicine of Ribeirão Preto University of São Paulo Ribeirão Preto Brazil
- Venue
- Human Psychopharmacology: Clinical and Experimental
- Publisher
- Wiley
- Published
- 2012-06-18
- Volume
- 27
- Issue
- 4
- Pages
- 378-385
- ISSN
- 0885-6222 (ISSN-L)
- 1099-1077
- OpenAlex
- W1517355001
- Cited by
- 39
- References
- 43
- Citations by year
- 2026: 2 · 2025: 4 · 2024: 1 · 2022: 2 · 2021: 1 · 2020: 3 · 2019: 4 · 2017: 6 · 2016: 4 · 2015: 3 · 2014: 5 · 2013: 4
- FWCI
- 5.77
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Human Psychopharmacology Clinical and Experimental (publishedVersion)
- PubMed (publishedVersion)
- Scientific Electronic Library Online (São Paulo Research Foundation, Latin American and Caribbean Center on Health Sciences Information, Conselho Nacional de Desenvolvimento Científico e Tecnológico) (publishedVersion)
- Funders
- Fundação de Amparo à Pesquisa do Estado de São Paulo
- Coordenação de Aperfeiçoamento de Pessoal de Nível Superior
- Conselho Nacional de Desenvolvimento Científico e Tecnológico
- Topics
- Social Sciences › Psychology › Social Psychology › Neuroendocrine regulation and behavior
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuropeptides and Animal Physiology
- Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
- Keywords
- oxytocin, carbon dioxide inhalation, anxiety, anxiolytic effects, lorazepam, salivary cortisol, heart rate, blood pressure, skin conductance
- MeSH terms
- Administration, Inhalation, Administration, Intranasal, Adult, Anxiety, Blood Pressure, Carbon Dioxide, Heart Rate, Humans, Hydrocortisone, Lorazepam, Male, Oxytocin, Saliva, Skin, Time Factors, Anti-Anxiety Agents, Single-Blind Method
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