Relationship of plasma amphetamine levels to physiological, subjective, cognitive and biochemical measures in healthy volunteers
Abstract
Acute administration of the stimulant dextro-amphetamine produces multiple physiological, subjective cognitive and biochemical changes. These effects are similar to those seen in mania, and may be a useful model for mania. The aim of the present study was more fully to determine the multiple effects of dextro-amphetamine and to relate these to changes in plasma levels of the drug. In a double-blind, placebo-controlled crossover study in 25 healthy volunteers (ages 18-45), the effects of 25 mg of oral dextro-amphetamine were examined. Physiological, subjective, cognitive changes, concentrations of amino acids and metabolites of biogenic amines period were related to changes in plasma amphetamine concentrations over 500 min. Peak concentrations of dextro-amphetamine occurred at 2.5-3.5 h post-administration and levels decreased to 75% of peak value after 500 min. The results from the present study indicate that the subjective psychological, cognitive and blood pressure changes frequently did not mirror the time course of plasma levels of the drug. Thus, there was no clear-cut relationship between plasma levels and effects. In addition, dextro-amphetamine caused no significant changes in amino acids or amino metabolite concentrations. In conclusion, while dextro-amphetamine administration definitely causes several changes which are seen in mania, there remain some physiological and metabolic differences between these two conditions.
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Eight of 14 studies using other attention tasks reported that amphetamine improves attention.
“Eight of the 14 studies reported that AMP improves attention (Asghar et al., 2003; Barch & Carter, 2005; Comer et al., 1996; Dolder et al., 2018; Servan‐Schreiber et al., 1998; Silber et al., 2006; Sofuoglu et al., 2008; Willson et al., 2004).”
From Systematic reviews of the acute effects of amphetamine on working memory and other cognitive performances in healthy individuals, with a focus on the potential influence of personality traits (2023) · cites this paper as Asghar et al., 2003
Evidence showed no well-defined association between cognitive effects and plasma concentration of dexamphetamine.
“Furthermore, evidence showed no well‐defined association between cognitive effects and plasma concentration of dexamphetamine (e.g., Asghar et al., 2003).”
From Systematic reviews of the acute effects of amphetamine on working memory and other cognitive performances in healthy individuals, with a focus on the potential influence of personality traits (2023) · cites this paper as Asghar et al., 2003
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References 59 · Cited by 64
- Authors
- Asghar, S. J., Tanay, V. A. M. I., Baker, G. B., Greenshaw, A., & Silverstone, P. H.
- Affiliations
- University of Alberta (CA)
- Corresponding author
- Silverstone, Peter H.
- Venue
- Human Psychopharmacology: Clinical and Experimental
- Publisher
- Wiley
- Published
- 2003-02-13
- Volume
- 18
- Issue
- 4
- Pages
- 291-299
- ISSN
- 0885-6222 (ISSN-L)
- 1099-1077
- OpenAlex
- W1982900708
- Cited by
- 64
- References
- 59
- Citations by year
- 2026: 2 · 2025: 1 · 2024: 1 · 2023: 3 · 2022: 3 · 2021: 3 · 2020: 1 · 2019: 3 · 2018: 4 · 2017: 3 · 2016: 2 · 2015: 4 · 2014: 4 · 2013: 1 · 2012: 2
- FWCI
- 2.04
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Human Psychopharmacology Clinical and Experimental (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Bipolar Disorder and Treatment
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Health Sciences › Medicine › Psychiatry and Mental health › Schizophrenia research and treatment
- Keywords
- plasma drug concentration, pharmacokinetics, stimulant effects, subjective effects, cognitive effects, blood pressure, amino acids, biogenic amine metabolites, healthy volunteers
- MeSH terms
- Adolescent, Adult, Central Nervous System Stimulants, Anxiety, Bipolar Disorder, Blood Pressure, Cognition, Dextroamphetamine, Double-Blind Method, Happiness, Humans, Hunger, Irritable Mood, Male, Middle Aged, Models, Biological, Psychomotor Agitation, Reaction Time, Time Factors, Cross-Over Studies
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