Sexual dysfunction in schizophrenia: focus on recent evidence
Abstract
Background: Antipsychotic medications are known to be commonly associated with sexual dysfunction. Sexual dysfunction is estimated to affect 30–80% of patients with schizophrenia and is a major cause of poor quality of life. However, few comparative studies on the sexual dysfunction effects associated with antipsychotic medication have been published and the effects of the newer atypical antipsychotics have been largely unexamined. Objective: This review aims to examine the latest evidence regarding the sexual function effects of different antipsychotic medications, particularly the newer prolactin‐sparing drugs, quetiapine and aripiprazole, in patients with schizophrenia and schizoaffective psychosis. Methods: A literature search was conducted within PubMed/MEDLINE using the terms risperidone, haloperidol, clozapine, olanzapine, ziprasidone, quetiapine, aripiprazole; sexual dysfunction; schizophrenia. The results were limited to studies published since 2002. Results: Recently published studies show that the relative impact of antipsychotics on sexual dysfunction can be summarised as risperidone > typical antipsychotics (haloperidol) > olanzapine > quetiapine > aripiprazole. Conclusions: The availability of prolactin‐sparing antipsychotics should enable psychiatrists to consider and manage proactively the sexual function consequences of pharmacological intervention, thereby improving sexual side effects, which may lead to improved treatment adherence and psychiatric outcome in patients with schizophrenia. Copyright © 2008 John Wiley & Sons, Ltd.
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Sexual dysfunction in schizophrenia is estimated to be more frequent compared to normal controls and to affect 30-80% of women and 45-80% of men.
“Although there are relatively few systematic investigations concerning sexual disorders in schizophrenia (514), sexual dysfunction in schizophrenia is, compared to normal controls, estimated to be more frequent (515-519) and to affect 30-80% of women and 45-80% of men (512,515, 520-523).”
From Physical illness in patients with severe mental disorders. I. Prevalence, impact of medications and disparities in health care (2011) · cites this paper as [520]
The relative impact of antipsychotics on sexual dysfunction can be summarized as: paliperidone = risperidone > haloperidol > olanzapine ≥ ziprasidone > clozapine ≥ quetiapine > aripiprazole.
“These studies suggest that the relative impact of AP on sexual dysfunction can be summarized as: paliperidone = risperidone > haloperidol > olanzapine ≥ ziprasidone > clozapine ≥ quetiapine > aripiprazole (503,520,536).”
From Physical illness in patients with severe mental disorders. I. Prevalence, impact of medications and disparities in health care (2011) · cites this paper as [520]
Conventional antipsychotics cause less sexual dysfunction than risperidone but more than the other novel antipsychotics.
“Conventional AP cause less sexual dysfunction than risperidone but more than the other novel AP (520,522).”
From Physical illness in patients with severe mental disorders. I. Prevalence, impact of medications and disparities in health care (2011) · cites this paper as [520]
This dysfunction can be secondary to the disease itself and to comorbid physical disorders, or be an adverse event of antipsychotics.
“This dysfunction can be secondary to the disease itself and to comorbid physical disorders, or be an adverse event of AP (520,524,525).”
From Physical illness in patients with severe mental disorders. I. Prevalence, impact of medications and disparities in health care (2011) · cites this paper as [520]
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References 57 · Cited by 191
- Authors
- Baggaley, M.
- Affiliations
- Guy's Hospital (GB)
- Corresponding author
- Baggaley, Martin
- ORCID
- Baggaley, Martin
- Venue
- Human Psychopharmacology: Clinical and Experimental
- Publisher
- Wiley
- Published
- 2008-03-13
- Volume
- 23
- Issue
- 3
- Pages
- 201-209
- ISSN
- 0885-6222 (ISSN-L)
- 1099-1077
- OpenAlex
- W1975768376
- Cited by
- 191
- References
- 57
- Citations by year
- 2026: 2 · 2025: 2 · 2024: 5 · 2023: 13 · 2022: 7 · 2021: 13 · 2020: 13 · 2019: 8 · 2018: 15 · 2017: 13 · 2016: 8 · 2015: 14 · 2014: 12 · 2013: 12 · 2012: 13
- FWCI
- 1.71
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Human Psychopharmacology Clinical and Experimental (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Schizophrenia research and treatment
- Health Sciences › Medicine › Psychiatry and Mental health › Sexual function and dysfunction studies
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Keywords
- sexual dysfunction, schizophrenia, antipsychotic adverse effects, atypical antipsychotics, quetiapine, aripiprazole, risperidone, olanzapine, haloperidol, clozapine, ziprasidone, schizoaffective psychosis, quality of life
- MeSH terms
- Ejaculation, Humans, Hyperprolactinemia, Libido, Prolactin, Schizophrenia, Schizophrenic Psychology, Sexual Dysfunction, Physiological, Antipsychotic Agents
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