Challenges associated with identifying the environmental determinants of the inflammatory bowel diseases
Abstract
In the last several years there has been an explosion in the discovery of inflammatory bowel disease (IBD) susceptibility genes; however, similar advances in identifying and defining environmental risk factors associated with IBD have lagged behind. Moreover, many studies that have explored the same or similar environmental risk factors of IBD have demonstrated disparate results and come to conflicting conclusions. In order for the field to move forward, it is important to understand and resolve why these differences exist. This significant heterogeneity has blurred the identification of the fundamental environmental determinants of IBD. The purpose of this review article is to explore the factors that have likely contributed to the heterogeneity among observational studies of environmental risk factors in IBD. In doing so, it is hoped that methodological standardization may lead to consistent environmental associations.
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The high reported incidence of IBD in Nova Scotia, Canada, might be methodological because incidence calculations relied on administrative databases using non-validated coding algorithms subject to misclassification biases.
“The high incidence of IBD in Nova Scotia might be methodological in origin because incidence calculations relied on administrative databases using non-validated coding algorithms, which are subject to misclassification biases that might have inflated the incidence45.”
From The four epidemiological stages in the global evolution of inflammatory bowel disease (2021) · cites this paper as [45]
The heterogeneity in incidence in newly industrialized countries is partly explained by the challenge of conducting high-quality population-based chronic disease surveillance due to regional population differences that make generalizing findings difficult.
“In part, the explanation for this heterogeneity is the challenge of conducting high-quality population-based chronic disease surveillance research in newly industrialized countries, due to the differences between regional populations (for example, the degree of westernization of diets and lifestyles) that make it difficult to generalize findings45,52,53.”
From The four epidemiological stages in the global evolution of inflammatory bowel disease (2021) · cites this paper as [45]
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References 60 · Cited by 109
- Authors
- Molodecky, N. A., Panaccione, R., Ghosh, S., Barkema, H. W., & Kaplan, G. G.
- Affiliations
- University of Calgary (CA)
- Venue
- Inflammatory Bowel Diseases
- Publisher
- Oxford University Press (OUP)
- Published
- 2011-08
- Volume
- 17
- Issue
- 8
- Pages
- 1792-1799
- ISSN
- 1078-0998 (ISSN-L)
- OpenAlex
- W1981748239
- Cited by
- 109
- References
- 60
- Citations by year
- 2026: 4 · 2025: 7 · 2024: 4 · 2023: 13 · 2022: 4 · 2021: 2 · 2020: 3 · 2019: 5 · 2018: 5 · 2017: 10 · 2016: 12 · 2015: 13 · 2014: 10 · 2013: 8 · 2012: 7
- FWCI
- 0.54
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Inflammatory Bowel Diseases (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Alberta Heritage Foundation for Medical Research
- Alberta Innovates
- Canadian Institutes of Health Research
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Inflammatory Bowel Disease
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic Associations and Epidemiology
- Keywords
- inflammatory bowel disease, environmental risk factors
- MeSH terms
- Colitis, Ulcerative, Crohn Disease, Environment, Humans, Research Design, Risk Factors, Bias, Genetic Predisposition to Disease
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