The DOI matches its Crossref record; 20 of the 20 references it cites were found in a registry or an index.
Overexpression of fatty acid synthase is an early and common event in the development of prostate cancer
Abstract
The expression of fatty acid synthase (FAS), a key lipogenic enzyme and potential target for antineoplastic therapy, was analyzed in 87 frozen needle biopsies of prostate cancer using a highly sensitive immunohistochemical detection technique (Envision). In comparison to normal or benign, hyperplastic glandular structures, which were all negative for FAS staining, immunohistochemical signal was evident in 24/25 low grade prostatic epithelial neoplasia (PIN) lesions, in 26/26 high grade PIN lesions and in 82/87 invasive carcinomas. Staining intensity tended to increase from low grade to high grade PIN to invasive carcinoma. Cancers with a high FAS expression had an overall high proliferative index. No correlation was found between FAS expression and lipid accumulation. These findings indicate that increased FAS expression is one of the earliest and most common events in the development of prostate cancer, suggesting that FAS may be used as a general prostate cancer marker and that antineoplastic therapy based on FAS inhibition may be an option for chemoprevention or curative treatment for nearly all prostate cancers. © 2001 Wiley‐Liss, Inc.
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Fatty acid synthesis: a potential selective target for antineoplastic therapy
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Increased expression of fatty acid synthase (OA-519) in ovarian neoplasms predicts shorter survival
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Selective activation of the fatty acid synthesis pathway in human prostate cancer
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Self-citationAndrogens stimulate fatty acid synthase in the human prostate cancer cell line LNCaP.
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Cited by
Fatty acid synthase and the lipogenic phenotype in cancer pathogenesis
Menendez, J. A., & Lupu, R. (2007) · Nature Reviews Cancer · doi:10.1038/nrc2222 · Cited by 2,941
Schug, Z. T., Peck, B., Jones, D. T., Zhang, Q., Grosskurth, S., Alam, I. S., Goodwin, L. M., Smethurst, E., Mason, S., Blyth, K., et al. (2015) · Cancer Cell · doi:10.1016/j.ccell.2014.12.002 · Cited by 820
Lipid metabolism in cancer: New perspectives and emerging mechanisms
Broadfield, L. A., Pane, A. A., Talebi, A., Swinnen, J. V., & Fendt, S.-M. (2021) · Developmental Cell · doi:10.1016/j.devcel.2021.04.013 · Cited by 758
Self-citationLipids and cancer: Emerging roles in pathogenesis, diagnosis and therapeutic intervention
Butler, L. M., Perone, Y., Dehairs, J., Lupien, L. E., de Laat, V., Talebi, A., Loda, M., Kinlaw, W. B., & Swinnen, J. V. (2020) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2020.07.013 · Cited by 589
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Metadata
- Authors
- Swinnen, J. V., Roskams, T., Joniau, S., Van Poppel, H., Oyen, R., Baert, L., Heyns, W., & Verhoeven, G.
- Venue
- International Journal of Cancer
- Publisher
- Wiley
- Published
- 2001-11-29
- Volume
- 98
- Issue
- 1
- Pages
- 19-22
- ISSN
- 0020-7136 (ISSN-L)
- 1097-0215
- OpenAlex
- W2032691440
- Cited by
- 381
- References
- 20
- FWCI
- 4.01
- Type
- journal article
- Language
- en
- Open access
- closed
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- Swinnen, J. V., Roskams, T., Joniau, S., Van Poppel, H., Oyen, R., Baert, L., Heyns, W., & Verhoeven, G. (2002). Overexpression of fatty acid synthase is an early and common event in the development of prostate cancer. International Journal of Cancer. https://doi.org/10.1002/ijc.10127
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