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Ovarian cancer antigen CA125 is encoded by the MUC16 mucin gene
Abstract
Serum assays based on the CA125 antigen are widely used in the monitoring of patients with ovarian cancer; however very little is known about the molecular nature of the CA125 antigen. We recently cloned a partial cDNA (designated MUC16) that codes for a new mucin that is a strong candidate for being the CA125 antigen. This assignment has now been confirmed by transfecting a partial MUC16 cDNA into 2 CA125‐negative cell lines and demonstrating the synthesis of CA125 by 3 different assays. Of the 3 antibodies (OC125, M11 and VK‐8) tested on the transfected cells, only the first 2 were strongly positive, indicating the differential expression of the CA125 epitopes in these cells. The cloning and expression of CA125 antigen opens the way to an understanding of its function in normal and malignant cells. © 2002 Wiley‐Liss, Inc.
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Cited by
Hansson, G. C. (2020) · Annual Review of Biochemistry · doi:10.1146/annurev-biochem-011520-105053 · Cited by 409
Roles of CA125 in diagnosis, prediction, and oncogenesis of ovarian cancer
Zhang, M., Cheng, S., Jin, Y., Zhao, Y., & Wang, Y. (2021) · Biochimica et Biophysica Acta (BBA) - Reviews on Cancer · doi:10.1016/j.bbcan.2021.188503 · Cited by 384
Lactobacillus Adhesion to Mucus
Van Tassell, M. L., & Miller, M. J. (2011) · Nutrients · doi:10.3390/nu3050613 · Cited by 334
Wahrenbrock, M., Borsig, L., Le, D., Varki, N., & Varki, A. (2003) · Journal of Clinical Investigation · doi:10.1172/jci200318882 · Cited by 317
Andrianifahanana, M., Moniaux, N., & Batra, S. K. (2006) · Biochimica et Biophysica Acta (BBA) - Reviews on Cancer · doi:10.1016/j.bbcan.2006.01.002 · Cited by 314
Metadata
- Authors
- Yin, B. W. T., Dnistrian, A., & Lloyd, K. O.
- Venue
- International Journal of Cancer
- Publisher
- Wiley
- Published
- 2002-02-06
- Volume
- 98
- Issue
- 5
- Pages
- 737-740
- ISSN
- 0020-7136 (ISSN-L)
- 1097-0215
- OpenAlex
- W2014947083
- Cited by
- 239
- References
- 0
- FWCI
- 3.02
- Type
- journal article
- Language
- en
- Open access
- closed
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- Yin, B. W. T., Dnistrian, A., & Lloyd, K. O. (2002). Ovarian cancer antigen CA125 is encoded by the MUC16 mucin gene. International Journal of Cancer. https://doi.org/10.1002/ijc.10250
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