Accuracy of human papillomavirus testing in primary screening of cervical neoplasia: Results from a multicenter study in India
Open accessAbstract
The knowledge that cervical neoplasia are caused by human papillomavirus (HPV) infection has led to the evaluation of its role in screening. We evaluated the accuracy of HPV testing by Hybrid capture II (HC II) method in detecting cervical intraepithelial neoplasia grade 2 and 3 (CIN 2 and 3) lesions in 4 cross‐sectional studies with common protocol and questionnaire in 3 different locations (Kolkata, Mumbai and Trivandrum) in India. These studies involved 18,085 women aged 25–65 years. The reference standard for final diagnosis was a combination of colposcopy/biopsy. All women were investigated with colposcopy and 3,116 received directed biopsy. The sensitivity of HPV testing for detecting CIN 2–3 lesions varied from 45.7% to 80.9% across the study sites; the specificity varied from 91.7% to 94.6% and the positive predictive value from 6.7% to 13.7%. Retesting of 298 randomly chosen denatured samples in France revealed an agreement rate of 85.9% and a κ‐value of 0.72. Although HPV testing seems to be a promising approach for cervical cancer prevention, a large range in sensitivity was observed in our study, possibly due to variations in the quality of specimen collection and reference standards. A higher sensitivity was associated with the center performing the test well. Further developments in terms of more reproducible, less expensive and less sophisticated testing are essential to make the test feasible and effective in low‐resource settings. © 2004 Wiley‐Liss, Inc.
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In a multicenter cross-sectional study in India, HPV testing had similar sensitivity to detect CIN2/3 lesions as cytology and VIA.
“In a multicenter cross-sectional study in India, HPV testing had similar sensitivity to detect CIN 2=3 lesions as cytology and VIA.26”
From A cluster randomized controlled trial of visual, cytology and human papillomavirus screening for cancer of the cervix in rural India (2005) · cites this paper as [26]
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- Authors
- Sankaranarayanan, R., Chatterji, R., Shastri, S. S., Wesley, R. S., Basu, P., Mahe, C., Muwonge, R., Seigneurin, D., Somanathan, T., Roy, C., Kelkar, R., Chinoy, R., Dinshaw, K., Mandal, R., Amin, G., Goswami, S., Pal, S., Patil, S., Dhakad, N., Frappart, L., Fontaniere, B., & IARC Multicenter Study Group on Cervical Cancer Prevention in India
- Affiliations
- Centre international de recherche sur le cancer (FR)
- Chittaranjan National Cancer Institute (IN)
- Tata Memorial Hospital (IN)
- Regional Cancer Center, Thiruvananthapuram (IN)
- Centre Hospitalier Universitaire de Grenoble (FR)
- Hôpital Edouard Herriot (FR)
- Corresponding author
- Sankaranarayanan, Rengaswamy
- ORCID
- Venue
- International Journal of Cancer
- Publisher
- Wiley
- Published
- 2004-08-17
- Volume
- 112
- Issue
- 2
- Pages
- 341-347
- ISSN
- 0020-7136 (ISSN-L)
- 1097-0215
- OpenAlex
- W1988445349
- Cited by
- 127
- References
- 26
- Citations by year
- 2026: 3 · 2025: 2 · 2024: 3 · 2023: 1 · 2022: 3 · 2021: 2 · 2020: 2 · 2019: 4 · 2018: 2 · 2017: 5 · 2016: 6 · 2015: 10 · 2014: 6 · 2013: 8 · 2012: 9
- FWCI
- 6.95
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- International Journal of Cancer (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Bill and Melinda Gates Foundation
- PATH
- Topics
- Health Sciences › Medicine › Epidemiology › Cervical Cancer and HPV Research
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Women's cancer prevention and management
- Life Sciences › Immunology and Microbiology › Microbiology › Reproductive tract infections research
- Keywords
- HPV testing, Hybrid Capture 2, cervical intraepithelial neoplasia, CIN2/3, cervical cancer screening, diagnostic accuracy, sensitivity and specificity, colposcopy, targeted biopsy, resource-limited settings, India
- MeSH terms
- Adult, Aged, Biopsy, Uterine Cervical Neoplasms, Colposcopy, Cross-Sectional Studies, DNA, Viral, Female, Humans, India, Mass Screening, Middle Aged, Sensitivity and Specificity, Vaginal Smears, Reproducibility of Results, In Situ Hybridization, Papillomavirus Infections
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