A long‐term follow‐up study on the natural course of snus‐induced lesions among Swedish snus users
Abstract
Snus‐induced lesions (SILs) are mucosal changes that are regularly seen in users of moist snuff (snus). Their role in oral carcinogenesis remains undefined. Our aim was to assess the natural course of SILs over several decades. A cohort of 1,115 individuals with SILs, confirmed in 1973–1974 during a population‐based survey was followed for 27–29 years through multiple record linkages with virtually complete population‐ and health registers. A sample (n = 267) of the cohort members were invited for reexamination after 19–22 years. Register‐based follow‐up through January 2002 revealed a total of 3 incident cases of oral cancer (standardized incidence ratio of 2.3, 95% CI 0.5–6.7), none of which occurred at the site of the original SIL. There was a strong association noted between the degree of SIL and current snus consumption. The SILs had disappeared in all 62 individuals who had permanently quitted using snus. In no case did we observe an important clinical change for the worse among individuals who had decreased their use or continued unabatedly. While the incidence of oral cancer in this cohort of individuals with SILs tended to be higher than expected, we conclude that cancers rarely occur at the site of lesions observed in the distant past. © 2006 Wiley‐Liss, Inc.
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There is a strong association between the degree of snus-induced lesions (SILs) and current snus consumption.
“A strong association between the degree of snus-induced lesions (SILs) and current snus consumption (Roosaar et al. 2006)”
From Comparison of the Health Effects Associated with the Use of Snus and Tobacco-Free Oral Nicotine Pouches: A Systematic Review (2026) · cites this paper as Roosaar et al. 2006
There is a strong association between the degree of snus-induced lesions and current snus consumption (p < 0.01); there were 3 incident cases of oral cancer (IRR = 2.3; 95% CI: 0.5-6.7), none of which occurred at the site of the original snus-induced lesion.
“strong association between the degree of snus-induced lesions (SILs) and current snus consumption (hours and grams of snus consumption per day; p < 0.01).Moreover, there was a total of 3 incident cases of oral cancer (IRR = 2.3; 95% CI: 0.5-6.7),but none of which occurred at the site of the original SIL (2 out of 3 of such participants were daily smokers) (Roosaar et al. 2006).”
From Comparison of the Health Effects Associated with the Use of Snus and Tobacco-Free Oral Nicotine Pouches: A Systematic Review (2026) · cites this paper as Roosaar et al. 2006
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Research works printed but not linked: 18
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Cited by
Sorted by citations
Kopa-Stojak, P. N., & Pawliczak, R. (2026) · Exposure and Health · doi:10.1007/s12403-026-00812-w
- Authors
- Roosaar, A., Johansson, A. L. V., Sandborgh‐Englund, G., Nyrén, O., & Axéll, T.
- Venue
- International Journal of Cancer
- Publisher
- Wiley
- Published
- 2006-04-27
- Volume
- 119
- Issue
- 2
- Pages
- 392-397
- ISSN
- 0020-7136
- 1097-0215
- Cited by
- 34
- References
- 0
- Language
- en
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