The DOI matches its Crossref record; 38 of the 38 references it cites were found in a registry or an index.
Renal cell carcinoma does not express argininosuccinate synthetase and is highly sensitive to arginine deprivation via arginine deiminase
Abstract
Recently, pegylated arginine deiminase (ADI; EC 3.5.3.6) has been used to treat the patients with hepatocellular carcinoma or melanoma, in which the level of argininosuccinate synthetase (ASS) activity is low or undetectable. The efficacy of its antitumor activity largely depends on the level of intracellular ASS, which enables tumor cells to recycle citrulline to arginine. Thus, we examined the expression levels of ASS in various cancer cells and found that it is low in renal cell carcinoma (RCC) cells, rendering the cells highly sensitive to arginine deprivation by ADI treatment. Immunohistochemical analysis revealed that in biopsy specimens from RCC patients (n = 98), the expression of ASS is highly demonstrated in the epithelium of normal proximal tubule but not seen in tumor cells. Furthermore, RCC cells treated with ADI showed remarkable growth retardation in a dose dependent manner. ADI also exerted in vivo antiproliferative effect on the allografted renal cell carcinoma (RENCA) tumor cells and prolonged the survival of tumor-bearing mice. Histological examination of the tumors revealed that tumor angiogenesis and vascular endothelial growth factor (VEGF) expression were significantly diminished by ADI administration. Therefore, these findings suggest that arginine deprivation by ADI could provide a beneficial strategy for the treatment of RCC in ways of inhibitions of arginine availability and neovascularization.
Overview
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“Intriguingly, both ASS1 and ASL enzymes are frequently epigenetically silenced in melanoma, renal cell carcinoma and hepatocellular carcinoma (Bowles et al., 2008; Ensor et al., 2002; Yoon et al., 2007).”
From The emerging hallmarks of cancer metabolism (2016) · cites this paper as Yoon et al., 2007
Citations
Cites
Multiple Comparisons Using Rank Sums
Dunn, O. J. (1964) · Technometrics · doi:10.1080/00401706.1964.10490181 · Cited by 5,168
Papapetropoulos, A., García‐Cardeña, G., Madri, J. A., & Sessa, W. C. (1997) · Journal of Clinical Investigation · doi:10.1172/jci119868 · Cited by 1,195
Protein A, avidin, and biotin in immunohistochemistry.
Hsu, S. M., & Raine, L. (1981) · Journal of Histochemistry & Cytochemistry · doi:10.1177/29.11.6172466 · Cited by 638
Enzymes of Arginine Metabolism
Morris, S. M. (2004) · Journal of Nutrition · doi:10.1093/jn/134.10.2743s · Cited by 361
Incidence and distribution of argininosuccinate synthetase deficiency in human cancers
Dillon, B. J., Prieto, V. G., Curley, S. A., Ensor, M., Holtsberg, F. W., Bomalaski, J. S., & Clark, M. A. (2004) · Cancer · doi:10.1002/cncr.20057 · Cited by 317
Ensor, M., Holtsberg, F. W., Bomalaski, J. S., & Clark, M. A. (2002) · PubMed · Cited by 315
Sasaki, K., Hattori, T., Fujisawa, T., Takahashi, K., Inoue, H., & Takigawa, M. (1998) · The Journal of Biochemistry · doi:10.1093/oxfordjournals.jbchem.a021955 · Cited by 272
Izzo, F., Marra, P., Beneduce, G., Castello, G., Vallone, P., De Rosa, V., Cremona, F., Ensor, C. M., Holtsberg, F. W., Bomalaski, J. S., et al. (2004) · Journal of Clinical Oncology · doi:10.1200/jco.2004.11.120 · Cited by 250
Ascierto, P. A., Scala, S., Castello, G., Daponte, A., Simeone, E., Ottaiano, A., Beneduce, G., De Rosa, V., Izzo, F., Melucci, M. T., et al. (2005) · Journal of Clinical Oncology · doi:10.1200/jco.2005.02.0933 · Cited by 238
Relative importance of kidney and liver in synthesis of arginine by the rat
Featherston, W. R., Rogers, Q. R., & Freedland, R. (1973) · American Journal of Physiology-Legacy Content · doi:10.1152/ajplegacy.1973.224.1.127 · Cited by 186
Cited by
Sorted by citations
The emerging hallmarks of cancer metabolism
Pavlova, N. N., & Thompson, C. B. (2016) · Cell Metabolism · doi:10.1016/j.cmet.2015.12.006 · Cited by 5,926
Metabolic reprogramming in clear cell renal cell carcinoma
Wettersten, H. I., Aboud, O. A., Lara, P. N., & Weiss, R. H. (2017) · Nature Reviews Nephrology · doi:10.1038/nrneph.2017.59 · Cited by 587
Arginine deprivation and argininosuccinate synthetase expression in the treatment of cancer
Delage, B., Fennell, D. A., Nicholson, L., McNeish, I., Lemoine, N. R., Crook, T., & Szlosarek, P. W. (2010) · International Journal of Cancer · doi:10.1002/ijc.25202 · Cited by 441
Myeloid Cell-Derived Arginase in Cancer Immune Response
Grzywa, T. M., Sosnowska, A., Matryba, P., Rydzyńska, Z., Jasiński, M., Nowis, D., & Gołąb, J. (2020) · Frontiers in Immunology · doi:10.3389/fimmu.2020.00938 · Cited by 446
Kim, R. H., Coates, J. M., Bowles, T. L., McNerney, G. P., Sutcliffe-Goulden, J., Jung, J. U., Gandour‐Edwards, R. F., Chuang, F. Y. S., Bold, R. J., & Kung, H.-J. (2009) · Cancer Research · doi:10.1158/0008-5472.can-08-3157 · Cited by 321
Lucarelli, G. T., Loizzo, D., Franzin, R., Battaglia, S., Ferro, M., Cantiello, F., Castellano, G., Bettocchi, C., Ditonno, P., & Battaglia, M. (2019) · Expert Review of Molecular Diagnostics · doi:10.1080/14737159.2019.1607729 · Cited by 249
Metabolic rearrangements in primary liver cancers: cause and consequences
Satriano, L., Lewińska, M., Rodrigues, P. M., Bañales, J. M., & Andersen, J. B. (2019) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/s41575-019-0217-8 · Cited by 245
Arginine Deprivation as a Targeted Therapy for Cancer
Feun, L. G., You, M., Wu, C., Kuo, M. T., Wangpaichitr, M., Spector, S. A., & Savaraj, N. (2008) · Current Pharmaceutical Design · doi:10.2174/138161208784246199 · Cited by 236
Arginine Starvation Impairs Mitochondrial Respiratory Function in ASS1-Deficient Breast Cancer Cells
Qiu, F., Chen, Y.-R., Liu, X., Chu, C.-Y., Shen, L., Xu, J., Gaur, S., Forman, H. J., Zhang, H., Zheng, S. S., et al. (2014) · Science Signaling · doi:10.1126/scisignal.2004761 · Cited by 221
Metabolic reprogramming in renal cancer: Events of a metabolic disease
Chakraborty, S., Balan, M., Sabarwal, A., Choueiri, T. K., & Pal, S. (2021) · Biochimica et Biophysica Acta (BBA) - Reviews on Cancer · doi:10.1016/j.bbcan.2021.188559 · Cited by 214
IL‐8 induces exocytosis of arginase 1 by neutrophil polymorphonuclears in nonsmall cell lung cancer
Rotondo, R., Barisione, G., Mastracci, L., Grossi, F., Orengo, A. M., Costa, R., Truini, M., Fabbi, M., Ferrini, S., & Barbieri, O. (2009) · International Journal of Cancer · doi:10.1002/ijc.24448 · Cited by 198
Glazer, E. S., Piccirillo, M., Albino, V., Giacomo, R. D., Palaia, R., Mastro, A. A., Beneduce, G., Castello, G., Rosa, V. D., Petrillo, A., et al. (2010) · Journal of Clinical Oncology · doi:10.1200/jco.2009.26.7765 · Cited by 187
Oncometabolites: Unconventional triggers of oncogenic signalling cascades
Sciacovelli, M., & Frezza, C. (2016) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2016.04.025 · Cited by 184
Syed, N., Langer, J., Janczar, K., Singh, P., Nigro, C. L., Lattanzio, L., Coley, H. M., Hatzimichael, E. C., Bomalaski, J. S., Szlosarek, P. W., et al. (2013) · Cell Death and Disease · doi:10.1038/cddis.2012.197 · Cited by 167
Targeting arginine metabolism pathway to treat arginine-dependent cancers
Qiu, F., Huang, J., & Sui, M. (2015) · Cancer Letters · doi:10.1016/j.canlet.2015.04.020 · Cited by 158
Metabolic pathways of L-arginine and therapeutic consequences in tumors
Szefel, J., Danielak, A., & Kruszewski, W. J. (2018) · Advances in Medical Sciences · doi:10.1016/j.advms.2018.08.018 · Cited by 158
Arginine Metabolism in Bacterial Pathogenesis and Cancer Therapy
Xiong, L., Teng, J. L. L., Botelho, M. G., Lo, R. C., Lau, S. K. P., & Woo, P. C. Y. (2016) · International Journal of Molecular Sciences · doi:10.3390/ijms17030363 · Cited by 157
Bowles, T. L., Kim, R., Galante, J., Parsons, C. M., Virudachalam, S., Kung, H., & Bold, R. J. (2008) · International Journal of Cancer · doi:10.1002/ijc.23723 · Cited by 153
Phase I/II study of pegylated arginine deiminase (ADI-PEG 20) in patients with advanced melanoma
Ott, P. A., Carvajal, R. D., Pandit-Taskar, N., Jungbluth, A. A., Hoffman, E. W., Wu, B.-W., Bomalaski, J. S., Venhaus, R., Pan, L., Old, L. J., et al. (2013) · Investigational New Drugs · doi:10.1007/s10637-012-9862-2 · Cited by 146
Tsai, W.-B., Aiba, I., Lee, S.-Y., Feun, L. G., Savaraj, N., & Kuo, M. T. (2009) · Molecular Cancer Therapeutics · doi:10.1158/1535-7163.mct-09-0794 · Cited by 143
Nicholson, L. J., Smith, P. R., Hiller, L., Szlosarek, P. W., Kimberley, C., Sehouli, J., Koensgen, D., Mustea, A., Schmid, P., & Crook, T. (2009) · International Journal of Cancer · doi:10.1002/ijc.24546 · Cited by 133
Ochocki, J. D., Khare, S., Hess, M., Ackerman, D., Qiu, B., Daisak, J. I., Worth, A. J., Lin, N., Lee, P., Xie, H. J., et al. (2018) · Cell Metabolism · doi:10.1016/j.cmet.2018.04.009 · Cited by 128
Kobayashi, E., Masuda, M., Nakayama, R. T., Ichikawa, H., Satow, R., Shitashige, M., Honda, K., Yamaguchi, U., Shoji, A., Tochigi, N., et al. (2010) · Molecular Cancer Therapeutics · doi:10.1158/1535-7163.mct-09-0774 · Cited by 122
Kelly, M. P., Jungbluth, A. A., Wu, B.-W., Bomalaski, J. S., Old, L. J., & Ritter, G. (2011) · British Journal of Cancer · doi:10.1038/bjc.2011.524 · Cited by 117
Signaling, metabolism, and cancer: An important relationship for therapeutic intervention
Vaghari‐Tabari, M., Ferns, G. A., Qujeq, D., Andevari, A. N., Sabahi, Z., & Moein, S. (2021) · Journal of Cellular Physiology · doi:10.1002/jcp.30276 · Cited by 126
Feun, L. G., Marini, A., Walker, G., Elgart, G., Moffat, F., Rodgers, S. E., Wu, C. J., You, M., Wangpaichitr, M., Kuo, M. T., et al. (2012) · British Journal of Cancer · doi:10.1038/bjc.2012.106 · Cited by 113
Metabolomics and Metabolic Reprogramming in Kidney Cancer
Weiss, R. H. (2018) · Seminars in Nephrology · doi:10.1016/j.semnephrol.2018.01.006 · Cited by 110
Lam, A. T., Wong, G., Chow, H., Chong, H.-C., Chow, T. L., Kwok, S.-Y., Cheng, P. N.-M., Wheatley, D. N., Lo, W., & Leung, Y. (2010) · Pigment Cell & Melanoma Research · doi:10.1111/j.1755-148x.2010.00798.x · Cited by 99
Wangpaichitr, M., Sullivan, E. J., Theodoropoulos, G., Wu, C., You, M., Feun, L. G., Lampidis, T. J., Kuo, M. T., & Savaraj, N. (2012) · Molecular Cancer Therapeutics · doi:10.1158/1535-7163.mct-11-0599 · Cited by 94
Inhibition of arginase modulates T-cell response in the tumor microenvironment of lung carcinoma
Sosnowska, A., Chlebowska, J., Matryba, P., Pilch, Z., Greig, A., Wolny, A., Grzywa, T. M., Rydzyńska, Z., Sokołowska, O., Rygiel, T. P., et al. (2021) · OncoImmunology · doi:10.1080/2162402x.2021.1956143 · Cited by 98
Amino acid deprivation using enzymes as a targeted therapy for cancer and viral infections
Fernandes, H. S., Teixeira, C. S. S., Fernandes, P. A., Ramos, M. J., & Cerqueira, N. M. F. S. A. (2016) · Expert Opinion on Therapeutic Patents · doi:10.1080/13543776.2017.1254194 · Cited by 91
Lam, T. L., Wong, G., Chong, H.-C., Cheng, P. N.-M., Choi, S. C., Chow, T. L., Kwok, S.-Y., Poon, R. T. P., Wheatley, D. N., Lo, W., et al. (2009) · Cancer Letters · doi:10.1016/j.canlet.2008.11.031 · Cited by 87
Targeting extracellular nutrient dependencies of cancer cells
García‐Bermúdez, J., Williams, R. T., Guarecuco, R., & Birsoy, K. (2019) · Molecular Metabolism · doi:10.1016/j.molmet.2019.11.011 · Cited by 93
Zhi, Y., Wang, Q., Zi, M., Zhang, S., Ge, J., Liu, K., Lu, L., Fan, C., Yan, Q., Shi, L., et al. (2024) · Advanced Science · doi:10.1002/advs.202306515 · Cited by 99
Lü, Y., Wang, W., Wang, J., Yang, C., Mao, H.-M., Fu, X., Wu, Y., Cai, J., Han, J., Xu, Z., et al. (2013) · PLoS ONE · doi:10.1371/journal.pone.0073866 · Cited by 81
Novel drugs that target the metabolic reprogramming in renal cell cancer
van der Mijn, J. C., Panka, D. J., Geissler, A. K., Verheul, H. M. W., & Mier, J. W. (2016) · Cancer & Metabolism · doi:10.1186/s40170-016-0154-8 · Cited by 83
Yau, T. C. C., Cheng, P., Chan, P., Chen, L., Yuen, J. H. F., Pang, R. W. C., Fan, S. T., Wheatley, D. N., & Poon, R. T. P. (2015) · Investigational New Drugs · doi:10.1007/s10637-014-0200-8 · Cited by 79
Discriminating gastric cancer and gastric ulcer using human plasma amino acid metabolic profile
Jing, F., Hu, X., Cao, Y., Xu, M., Wang, Y., Jing, Y., Hu, X., Gao, Y., & Zhu, Z. (2018) · IUBMB Life · doi:10.1002/iub.1748 · Cited by 72
McAlpine, J. A., Lu, H.-T., Wu, K. C., Knowles, S. K., & Thomson, J. A. (2014) · BMC Cancer · doi:10.1186/1471-2407-14-621 · Cited by 67
Prudner, B. C., Rathore, R., Robinson, A. M., Godec, A., Chang, S. F., Hawkins, W. G., Hirbe, A. C., & Tine, B. A. V. (2019) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-19-0206 · Cited by 66
Khoury, O., Ghazale, N., Stone, E. M., El‐Sibai, M., Frankel, A. E., & Abi‐Habib, R. J. (2015) · Journal of Neuro-Oncology · doi:10.1007/s11060-014-1698-5 · Cited by 64
El‐Sayed, A. S. A., Shindia, A. A., Abou-Zeid, A. A., Yassin, A. M., Sitohy, M. Z., & Sitohy, B. (2019) · Enzyme and Microbial Technology · doi:10.1016/j.enzmictec.2019.109432 · Cited by 61
Romero, P. A., Stone, E. M., Lamb, C., Chantranupong, L., Krause, A., Miklos, A. E., Hughes, R. A., Fechtel, B. M., Ellington, A. D., Arnold, F. H., et al. (2012) · ACS Synthetic Biology · doi:10.1021/sb300014t · Cited by 60
Efficacy of arginine depletion by ADI-PEG20 in an intracranial model of GBM
Przystal, J. M., Hajji, N., Khozoie, C., Renziehausen, A., Zeng, Q., Abaitua, F., Hajitou, A., Suwan, K., Want, E. J., Bomalaski, J. S., et al. (2018) · Cell Death and Disease · doi:10.1038/s41419-018-1195-4 · Cited by 57
Tanios, R. F., Bekdash, A., Kassab, E., Stone, E. M., Georgiou, G., Frankel, A. E., & Abi‐Habib, R. J. (2013) · Leukemia Research · doi:10.1016/j.leukres.2013.08.007 · Cited by 55
Tate, D. J., Vonderhaar, D. J., Caldas, Y. A., Metoyer, T., Patterson, J. R., Avilés, D., & Zea, A. H. (2008) · Journal of Hematology & Oncology · doi:10.1186/1756-8722-1-14 · Cited by 56
Metabolic alterations in hereditary and sporadic renal cell carcinoma
Coffey, N. J., & Simon, M. C. (2024) · Nature Reviews Nephrology · doi:10.1038/s41581-023-00800-2 · Cited by 56
The arginine metabolism and its deprivation in cancer therapy
Feng, T., Xie, F., Lyu, Y., Yu, P., Chen, B., Yu, J., Zhang, G., To, K. F., Tsang, C. M., & Kang, W. (2025) · Cancer Letters · doi:10.1016/j.canlet.2025.217680 · Cited by 54
Arginine reprogramming in ADPKD results in arginine-dependent cystogenesis
Trott, J. F., Hwang, V. J., Ishimaru, T., Chmiel, K. J., Zhou, J. X., Shim, K., Stewart, B. J., Mahjoub, M. R., Jen, K., Barupal, D. K., et al. (2018) · American Journal of Physiology-Renal Physiology · doi:10.1152/ajprenal.00025.2018 · Cited by 52
Arginine deprivation therapy for malignant melanoma
Kim, K., Yoon, Y., Frankel, A. E., Feun, & Ekmekcioglu (2012) · Clinical Pharmacology Advances and Applications · doi:10.2147/cpaa.s37350 · Cited by 50
Pavlyk, I., Rzhepetskyy, Y., Jagielski, A. K., Drożak, J., Wasik, A., Pereverzieva, G., Brewińska‐Olchowik, M., Kunz‐Schughart, L. A., Stasyk, O. V., & Rędowicz, M. J. (2014) · Amino Acids · doi:10.1007/s00726-014-1857-1 · Cited by 50
Amino Acid Degrading Enzymes and their Application in Cancer Therapy
Pokrovsky, V. S., Chepikova, O. E., Давыдов, Д. Ж., Zamyatnin, A. A., Lukashev, A. N., & Lukasheva, E. V. (2017) · Current Medicinal Chemistry · doi:10.2174/0929867324666171006132729 · Cited by 50
Vynnytska‐Myronovska, B., Bobak, Y. P., Garbe, Y., Dittfeld, C., Stasyk, O. V., & Kunz‐Schughart, L. A. (2011) · International Journal of Cancer · doi:10.1002/ijc.26221 · Cited by 48
A cluster of long non-coding RNAs exhibit diagnostic and prognostic values in renal cell carcinoma
Cheng, G., Liu, D., Liang, H., Yang, H., Chen, K., & Zhang, X. (2019) · Aging · doi:10.18632/aging.102407 · Cited by 47
Amino Acids in Cancer and Cachexia: An Integrated View
Ragni, M., Fornelli, C., Nisoli, E., & Penna, F. (2022) · Cancers · doi:10.3390/cancers14225691 · Cited by 48
Argininosuccinate lyase is a potential therapeutic target in breast cancer
Huang, H.-L., Chen, W.-C., Hsu, H., Cho, C.-Y., Hung, Y.-H., Wang, C., & Lai, M.-D. (2015) · Oncology Reports · doi:10.3892/or.2015.4280 · Cited by 49
Prevention and treatment of cancers by immune modulating nutrients
Janakiram, N. B., Mohammed, A., Madka, V., Kumar, G., & Rao, C. V. (2016) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.201500884 · Cited by 48
Nasreddine, G., El‐Sibai, M., & Abi‐Habib, R. J. (2019) · Investigational New Drugs · doi:10.1007/s10637-019-00756-w · Cited by 46
Synakiewicz, A., Stachowicz‐Stencel, T., & Adamkiewicz‐Drożyńska, E. (2014) · Expert Opinion on Investigational Drugs · doi:10.1517/13543784.2014.934808 · Cited by 45
The Immune Microenvironment in Penile Cancer and Rationale for Immunotherapy
Ahmed, M. E., Falasiri, S. S. A., Hajiran, A. J., Chahoud, J., & Spiess, P. E. (2020) · Journal of Clinical Medicine · doi:10.3390/jcm9103334 · Cited by 45
Daylami, R., Muilenburg, D. J., Virudachalam, S., & Bold, R. J. (2014) · Journal of Experimental & Clinical Cancer Research · doi:10.1186/preaccept-8245834981349245 · Cited by 43
Chu, Y., Lai, M., & Yeh, C. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms241310668 · Cited by 44
Liu, J., Ma, J., Wu, Z., Li, W., Zhang, D., Han, L., Wang, F., Reindl, K. M., Wu, E., & Ma, Q. (2014) · BMC Cancer · doi:10.1186/1471-2407-14-686 · Cited by 41
Arginine deprivation as a new treatment strategy for head and neck cancer
Huang, C., Tsai, S., Kuo, C., Chang, J. S.-M., Jin, Y., Chang, J., & Hsiao, J. (2012) · Oral Oncology · doi:10.1016/j.oraloncology.2012.06.004 · Cited by 41
Burrows, N., Cane, G., Robson, M. P., Gaude, E., Howat, W., Szlosarek, P. W., Pedley, R. B., Frezza, C., Ashcroft, M. A., & Maxwell, P. H. (2016) · Scientific Reports · doi:10.1038/srep22950 · Cited by 39
Wang, Y., Liu, X., Gong, L., Ding, W., Hao, W., Peng, Y., Zhang, J., Cai, W., & Gao, Y. (2023) · British Journal of Pharmacology · doi:10.1111/bph.16252 · Cited by 37
Attenuation of Argininosuccinate Lyase Inhibits Cancer Growth via Cyclin A2 and Nitric Oxide
Huang, H.-L., Hsu, H., Shieh, S.-C., Chang, Y.-S., Chen, W.-C., Cho, C.-Y., Teng, C., Su, I., Hung, W.-C., & Lai, M.-D. (2013) · Molecular Cancer Therapeutics · doi:10.1158/1535-7163.mct-12-0863 · Cited by 37
Mechanism‐based treatment of cancer with immune checkpoint inhibitor therapies
Abdou, Y. G., Pandey, M. R., Sarma, M., Shah, S., Baron, J. I., & Ernstoff, M. S. (2020) · British Journal of Clinical Pharmacology · doi:10.1111/bcp.14316 · Cited by 35
Bacterial proteins as potential drugs in the treatment of leukemia
Kwan, J. M., Fialho, A. M., Kundu, M., Thomas, J., Hong, C. S., Gupta, T. K. D., & Chakrabarty, A. M. (2009) · Leukemia Research · doi:10.1016/j.leukres.2009.01.024 · Cited by 36
Chen, Y., Yang, L., Lu, Y., Liu, N., Ma, W., Fan, H., Hu, Q., Han, X., Gan, W., & Li, D. (2022) · Cancer Letters · doi:10.1016/j.canlet.2022.215689 · Cited by 34
Liu, Q., Stewart, J., Wang, H., Rashid, A., Zhao, J., Katz, M. H. G., Lee, J. E., Fleming, J. B., Maitra, A., Wolff, R. A., et al. (2017) · PLoS ONE · doi:10.1371/journal.pone.0171985 · Cited by 34
Agnello, G., Alters, S. E., & Rowlinson, S. W. (2019) · Translational research · doi:10.1016/j.trsl.2019.12.005 · Cited by 34
Zhu, L., Verma, R., Roccatano, D., Ni, Y., Sun, Z., & Schwaneberg, U. (2010) · ChemBioChem · doi:10.1002/cbic.201000458 · Cited by 33
Lagarde, S. M., van Themaat, P. E. V. L., Moerland, P. D., Gilhuijs-Pederson, L. A., ten Kate, F. J. W., Reitsma, P. H., van Kampen, A. H. C., Zwinderman, A. H., Baas, F., & van Lanschot, J. J. B. (2008) · Annals of Surgical Oncology · doi:10.1245/s10434-008-0165-y · Cited by 33
Thongkum, A., Wu, C., Li, Y.-Y., Wangpaichitr, M., Navasumrit, P., Parnlob, V., Sricharunrat, T., Bhudhisawasdi, V., Ruchirawat, M., & Savaraj, N. (2017) · International Journal of Molecular Sciences · doi:10.3390/ijms18061175 · Cited by 33
The relationship of arginine deprivation, argininosuccinate synthetase and cell death in melanoma.
Savaraj, N., Wu, C., Kuo, M. T., You, M., Wangpaichitr, M., Robles, C., Spector, S. A., & Feun, L. G. (2007) · Europe PMC (PubMed Central) · Cited by 32
Husain, I., Bala, K., Wani, A., Makhdoomi, U. S., Malik, F. A., & Sharma, A. (2017) · Chemico-Biological Interactions · doi:10.1016/j.cbi.2017.07.001 · Cited by 31
Mao, H.-M., Wei, W., Xiong, W., Lü, Y., Chen, B.-G., & Liu, Z. (2010) · Clinical Biochemistry · doi:10.1016/j.clinbiochem.2010.05.017 · Cited by 31
Arginine depriving enzymes: applications as emerging therapeutics in cancer treatment
Kumari, N., & Bansal, S. (2021) · Cancer Chemotherapy and Pharmacology · doi:10.1007/s00280-021-04335-w · Cited by 30
The Relationship of Arginine Deprivation, Argininosuccinate Synthetase and Cell Death in Melanoma
Savaraj, N., Wu, C., Kuo, M. T., You, M., Wangpaichitr, M., Robles, C., Spector, S. A., & Feun, L. G. (2007) · Drug Target Insights · doi:10.1177/117739280700200016 · Cited by 30
Fayura, L. R., Boretsky, Y. R., Pynyaha, Y. V., Wheatley, D. N., & Sibirny, A. А. (2013) · Journal of Biotechnology · doi:10.1016/j.jbiotec.2013.06.025 · Cited by 29
Strategies for optimizing the serum persistence of engineered human arginase I for cancer therapy
Stone, E. M., Chantranupong, L., Gonzalez, C., O’Neal, J. F., Rani, M., Berg, C. L. V. D., & Georgiou, G. (2011) · Journal of Controlled Release · doi:10.1016/j.jconrel.2011.09.097 · Cited by 28
Shuvayeva, G., Bobak, Y. P., Igumentseva, N. I., Titone, R., Morani, F., Stasyk, O. V., & Isidoro, C. (2014) · BioMed Research International · doi:10.1155/2014/505041 · Cited by 27
Khalil, N., & Abi‐Habib, R. J. (2019) · Investigational New Drugs · doi:10.1007/s10637-019-00883-4 · Cited by 27
Treating liver cancer through arginine depletion
Prasad, Y. R., Anakha, J., & Pande, A. H. (2024) · Drug Discovery Today · doi:10.1016/j.drudis.2024.103940 · Cited by 27
Snail enhances arginine synthesis by inhibiting ubiquitination-mediated degradation of ASS1
Jia, H., Yang, Y., Li, M., Chu, Y., Song, H., Zhang, J., Zhang, D., Zhang, Q., Xu, Y., Wang, J., et al. (2021) · EMBO Reports · doi:10.15252/embr.202051780 · Cited by 23
Differential expression of argininosuccinate synthetase in serous and non‐serous ovarian carcinomas
Cheon, D., Walts, A. E., Beach, J. A., Lester, J., Bomalaski, J. S., Walsh, C., Wiedemeyer, W. R., Karlan, B. Y., & Oršulić, S. (2014) · The Journal of Pathology Clinical Research · doi:10.1002/cjp2.4 · Cited by 24
Protein Engineering of the Antitumor Enzyme PpADI for Improved Thermal Resistance
Zhu, L., Cheng, F., Piatkowski, V., & Schwaneberg, U. (2013) · ChemBioChem · doi:10.1002/cbic.201300433 · Cited by 23
Kim, J. H., Kim, J. H., Yu, Y. S., Kim, D. H., Kim, C. J., & Kim, K. (2009) · Investigative Ophthalmology & Visual Science · doi:10.1167/iovs.08-2623 · Cited by 21
Changes in arginase isoenzymes pattern in human hepatocellular carcinoma
Chrzanowska, A., Krawczyk, M., & Barańczyk‐Kuźma, A. (2008) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2008.09.093 · Cited by 21
Swayden, M., Bekdash, A., Fakhoury, I., Atat, O. E., Borjac, J., El‐Sibai, M., & Abi‐Habib, R. J. (2020) · Human Cell · doi:10.1007/s13577-020-00437-4 · Cited by 19
Abbott, K. L., Ali, A., Reinfeld, B. I., Deik, A., Subudhi, S., Landis, M. D., Hongo, R. A., Young, K. L., Kunchok, T., Nabel, C. S., et al. (2024) · eLife · doi:10.7554/elife.95652 · Cited by 22
Stelter, L., Evans, M. J., Jungbluth, A. A., ZANZONICO, P. B., Ritter, G., Ku, T. W., Rosenfeld, E., Bomalaski, J. S., Old, L. J., & Larson, S. M. (2012) · Journal of Nuclear Medicine · doi:10.2967/jnumed.111.092973 · Cited by 18
An eleven metabolic gene signature-based prognostic model for clear cell renal cell carcinoma
Wu, Y., Wei, X., Feng, H., Hu, B., Liu, B., Luan, Y., Ruan, Y., Liu, X., Liu, Z., Wang, S., et al. (2020) · Aging · doi:10.18632/aging.104088 · Cited by 18
Vynnytska‐Myronovska, B., Kurlishchuk, Y. V., Bobak, Y. P., Dittfeld, C., Kunz‐Schughart, L. A., & Stasyk, O. V. (2013) · Amino Acids · doi:10.1007/s00726-013-1586-x · Cited by 18
Predictive markers for efficiency of the amino-acid deprivation therapies in cancer
Pokrovsky, V. S., Qoura, L. A., Morozova, E. A., & Bunik, V. I. (2022) · Frontiers in Medicine · doi:10.3389/fmed.2022.1035356 · Cited by 17
Arginine Is a Novel Drug Target for Arginine Decarboxylase in Human Colorectal Cancer Cells
Wei, X., Chow, H., Chong, H.-C., Leung, S.-L., Ho, M.-K., Lee, L. M.-Y., & Leung, Y. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms241813741 · Cited by 18
Yang, H., Lin, M. T., Xiong, F., Yang, Y., Nie, X., McNutt, M. A., & Zhou, R. (2011) · Surgery Today · doi:10.1007/s00595-010-4338-5 · Cited by 17
Srivastava, A., Meena, S. K., Alam, M., Nayeem, S. M., Deep, S., & Sau, A. K. (2012) · Biochemistry · doi:10.1021/bi301421v · Cited by 17
Park, H., Lee, J., Shim, Y.-J., Shin, Y., Jeong, S.-Y., Oh, J., Park, G. H., Lee, K.-H., & Min, B.-H. (2008) · Molecules and Cells · doi:10.1016/s1016-8478(23)17586-8 · Cited by 17
Metadata
- Authors
- Yoon, C., Shim, Y., Kim, E., Lee, J., Won, N., Kim, J., Park, I., Yoon, D., & Min, B.
- Affiliations
- Korea University (KR)
- Seoul National University (KR)
- Inha University (KR)
- Corresponding author
- Min, Bon‐Hong
- Venue
- International Journal of Cancer
- Publisher
- Wiley
- Published
- 2006-12-27
- Volume
- 120
- Issue
- 4
- Pages
- 897-905
- ISSN
- 0020-7136 (ISSN-L)
- 1097-0215
- OpenAlex
- W1983116683
- Cited by
- 165
- References
- 37
- Citations by year
- 2026: 8 · 2025: 6 · 2024: 9 · 2023: 9 · 2022: 7 · 2021: 9 · 2020: 9 · 2019: 9 · 2018: 9 · 2017: 11 · 2016: 8 · 2015: 7 · 2014: 10 · 2013: 8 · 2012: 10
- FWCI
- 4.95
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- International Journal of Cancer (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Korea Health 21 R&D Project, Ministry of Health and Welfare, Republic of Korea (A050252)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Biotechnology › Bacterial Cancer Therapy
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Amino Acid Enzymes and Metabolism
- Health Sciences › Medicine › Oncology › Renal cell carcinoma treatment
- Keywords
- renal cell carcinoma, argininosuccinate synthetase, arginine deiminase, arginine deprivation, tumor growth inhibition, tumor angiogenesis, vascular endothelial growth factor, neovascularization, proximal tubule, Renca cells, cancer therapy
- MeSH terms
- Adult, Aged, Animals, Arginase, Arginine, Argininosuccinate Synthase, Carcinoma, Renal Cell, Citrulline, Female, Humans, Hydrolases, Kidney Neoplasms, Male, Mice, Inbred BALB C, Middle Aged, Neovascularization, Pathologic, Polyethylene Glycols, Tumor Cells, Cultured, Survival Rate, Xenograft Model Antitumor Assays, Vascular Endothelial Growth Factor A, Cell Growth Processes, Mice
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review