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Cited by 106Cervical Cancer and HPV ResearchWomen's cancer prevention and managementReproductive tract infections research

Looking ahead: A case for human papillomavirus testing of self‐sampled vaginal specimens as a cervical cancer screening strategy

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Gravitt, Patti E., Belinson, Jerome L., Salmeron, Jorge, Shah, Keerti V.·2011·International Journal of Cancer
DOI 10.1002/ijc.25974PMC PMC3782104
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Abstract

Even in the era of highly effective human papillomavirus (HPV) prophylactic vaccines, substantial reduction in worldwide cervical cancer mortality will only be realized if effective early detection and treatment of the millions of women already infected and the millions who may not receive vaccination in the next decade can be broadly implemented through sustainable cervical cancer screening programs. Effective programs must meet three targets: (i) at least 70% of the targeted population should be screened at least once in a lifetime, (ii) screening assays and diagnostic tests must be reproducible and sufficiently sensitive and specific for the detection of high‐grade precursor lesions (i.e., CIN2+), and (iii) effective treatment must be provided. We review the evidence that HPV DNA screening from swabs collected by the women in their home or village is sufficiently sound for consideration as a primary screening strategy in the developing world, with sensitivity and specificity for detection of CIN2+ as good or better than Pap smear cytology and VIA. A key feature of a self‐collected HPV testing strategy (SC‐HPV) is the move of the primary screening activities from the clinic to the community. Efforts to increase the affordability and availability of HPV DNA tests, community education and awareness, development of strong partnerships between community advocacy groups, health care centers and regional or local laboratories, and resource appropriate strategies to identify and treat screen‐positive women should now be prioritized to ensure successful public health translation of the technologic advancements in cervical cancer prevention.

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Authors
Gravitt, P. E., Belinson, J. L., Salmeron, J., & Shah, K. V.
Affiliations
  • Johns Hopkins University (US)
  • Cleveland Clinic (US)
Corresponding author
Gravitt, Patti E.
ORCID
Venue
International Journal of Cancer
Publisher
Wiley
Published
2011-05-26
Volume
129
Issue
3
Pages
517-527
ISSN
  • 0020-7136 (ISSN-L)
  • 1097-0215
DOI
10.1002/ijc.25974
PMC
PMC3782104
OpenAlex
W2052304478
Cited by
106
References
76
Citations by year
2026: 2 · 2025: 3 · 2024: 2 · 2022: 4 · 2021: 2 · 2020: 5 · 2019: 5 · 2018: 6 · 2017: 9 · 2016: 8 · 2015: 14 · 2014: 16 · 2013: 10 · 2012: 17
FWCI
1.73
Type
journal article
Language
en
Open access
Licence
onlinelibrary.wiley.com/termsAndConditions#vor (vor)
Locations
  • International Journal of Cancer (publishedVersion)
  • PubMed (publishedVersion)
  • Europe PMC (PubMed Central) (acceptedVersion)
  • PubMed Central (acceptedVersion)
Funders
  • Hologic
  • National Institutes of Health
  • National Cancer Institute (P50 CA98252, P50CA098252)
Topics
  • Health Sciences › Medicine › Epidemiology › Cervical Cancer and HPV Research
  • Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Women's cancer prevention and management
  • Life Sciences › Immunology and Microbiology › Microbiology › Reproductive tract infections research
Keywords
HPV testing, cervical cancer screening, cervical intraepithelial neoplasia, Pap smear cytology, visual inspection with acetic acid, screening sensitivity and specificity, community-based screening, developing countries, cervical cancer prevention, HPV vaccination
MeSH terms
Uterine Cervical Dysplasia, Uterine Cervical Neoplasms, Developing Countries, Female, Humans, Sensitivity and Specificity, Vagina, Self-Examination, Papillomavirus Infections, Early Detection of Cancer

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