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Isolation of a human prostate carcinoma cell line (DU 145)
Abstract
A long‐term tissue culture cell line has been derived from a human prostate adenocarcinoma metastatic to the brain. The cell line, DU 145, has been passaged 90 times in vitro over a period of 2 years. The cells are epithelial, grow in isolated islands on plastic Petri dishes, and form colonies in soft agar suspension culture. Karyotypic analysis demonstrates an aneuploid human karyotype with a modal chromosome number of 64. Distinctive marker chromosomes (a translocation Y chromosome, metacentric minute chromosomes and three large acrocentic chromosomes) have been identified. Electron microscopy of the original tumor tissue and of the tissue culture cell line show a remarkable similarity in cell organelle structure.
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DU145 cells are CNS metastases-derived primary prostate adenocarcinoma cells.
“This is an interesting finding as PNT1 cells are a nontumorigenic immortalized prostate epithelial line (43), yet show a similar lipidome to CNS metastases-derived DU145 primary prostate adenocarcinoma cells (44).”
From FACS-assisted single-cell lipidome analysis of phosphatidylcholines and sphingomyelins in cells of different lineages (2023) · cites this paper as [44]
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Metadata
- Authors
- Stone, K. R., Mickey, D. D., Wunderli, H., Mickey, G. H., & Paulson, D. F.
- Venue
- International Journal of Cancer
- Publisher
- Wiley
- Published
- 1978-03-15
- Volume
- 21
- Issue
- 3
- Pages
- 274-281
- ISSN
- 0020-7136
- 1097-0215
- Cited by
- 926
- References
- 0
- Language
- en
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