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Properties of a non‐tumorigenic human cervical keratinocyte cell line
Abstract
A human cervical keratinocyte cell line, W12, has been initiated from a low‐grade cervical lesion histologically diagnosed as CIN I. This cell line has, to date, undergone over 300 generations in vitro with an average doubling time of 30 hr: an aneuploid karyotype has developed with progressive in vitro growth. W12 contains HPV16 DNA present at approximately 100 copies and the state of the viral DNA over a number of passages has been examined. The HPV13 DNA is stably maintained at high copy number over several passages and restriction enzyme analysis together with electrophoresis of uncleaved viral DNA indicate that it is present predominantly as the episomal molecule. W12 cells exhibit a typical keratinocyte morphology and, when transplanted into the flank of the nude mouse, form an epithelial lesion with the histological features of CIN I/II.
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Citations
Cited by
Molecular biology of human papillomavirus infection and cervical cancer
Doorbar, J. (2006) · Clinical Science · doi:10.1042/cs20050369 · Cited by 1,072
Integration of high‐risk human papillomavirus: a key event in cervical carcinogenesis?
Pett, M., & Coleman, N. (2007) · The Journal of Pathology · doi:10.1002/path.2192 · Cited by 451
The nature of telomere fusion and a definition of the critical telomere length in human cells
Capper, R., Britt-Compton, B., Tankimanova, M., Rowson, J., Letsolo, B., Man, S., Haughton, M., & Baird, D. M. (2007) · Genes & Development · doi:10.1101/gad.439107 · Cited by 294
Amplification of human papillomavirus genomes in vitro is dependent on epithelial differentiation
Bedell, M. A., Hudson, J. B., Golub, T. R., Turyk, M. E., Hosken, M., Wilbanks, G. D., & Laimins, L. A. (1991) · Journal of Virology · doi:10.1128/jvi.65.5.2254-2260.1991 · Cited by 274
Talora, C., Sgroi, D. C., Crum, C. P., & Dotto, G. P. (2002) · Genes & Development · doi:10.1101/gad.988902 · Cited by 206
Metadata
- Authors
- Stanley, M. A., Browne, H. M., Appleby, M., & Minson, A. C.
- Venue
- International Journal of Cancer
- Publisher
- Wiley
- Published
- 1989-04-15
- Volume
- 43
- Issue
- 4
- Pages
- 672-676
- ISSN
- 0020-7136 (ISSN-L)
- 1097-0215
- OpenAlex
- W2071114176
- Cited by
- 267
- References
- 0
- FWCI
- 7.56
- Type
- journal article
- Language
- en
- Open access
- closed
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- Stanley, M. A., Browne, H. M., Appleby, M., & Minson, A. C. (1989). Properties of a non‐tumorigenic human cervical keratinocyte cell line. International Journal of Cancer. https://doi.org/10.1002/ijc.2910430422
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