The DOI matches its Crossref record.
Risk modifiers in carriers of brca1 mutations
Abstract
The majority of, but not all, women with mutations in the BRCAI gene will be affected with breast or ovarian cancer by the age of 70. To establish whether known risk factors modify susceptibility to cancer in these women, we have studied the reproductive histories of 333 North American women who were found by haplotype analysis to carry BRCAI mutations. An increased risk for breast cancer was associated with low parity and with recent birth cohort. The risk of ovarian cancer decreased with increasing age at last childbirth; however, in contrast to the case for sporadic cancer, the risk of ovarian cancer in BRCAI carriers was found to increase significantly with increasing parity. © 1995 Wiley‐Liss, Inc.
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Cited by
Gene–environment interactions in human diseases
Hunter, D. J. (2005) · Nature Reviews Genetics · doi:10.1038/nrg1578 · Cited by 1,132
Modification of BRCA1-associated breast cancer risk by the polymorphic androgen-receptor CAG repeat.
Rebbeck, T. R., Kantoff, P. W., Krithivas, K., Neuhausen, S., Blackwood, M. A., Godwin, A. K., Daly, M. B., Narod, S. A., Garber, J. E., Lynch, H. T., et al. (1999) · The American Journal of Human Genetics · doi:10.1086/302366 · Cited by 252
Self-citationFischer, C., Kuchenbäcker, K., Engel, C., Zachariae, S., Rhiem, K., Meindl, A., Rahner, N., Dikow, N., Plendl, H., Debatin, I., et al. (2013) · Journal of Medical Genetics · doi:10.1136/jmedgenet-2012-101415 · Cited by 94
Metadata
- Authors
- Narod, S. A., Goldgar, D., Cannon‐Albright, L., Weber, B., Moslehi, R., Ives, E., Lenoir, G., & Lynch, H.
- Venue
- International Journal of Cancer
- Publisher
- Wiley
- Published
- 1995-12-20
- Volume
- 64
- Issue
- 6
- Pages
- 394-398
- ISSN
- 0020-7136 (ISSN-L)
- 1097-0215
- OpenAlex
- W2145924652
- Cited by
- 164
- References
- 0
- FWCI
- 5.48
- Type
- journal article
- Language
- en
- Open access
- closed
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- Narod, S. A., Goldgar, D., Cannon‐Albright, L., Weber, B., Moslehi, R., Ives, E., Lenoir, G., & Lynch, H. (1995). Risk modifiers in carriers of brca1 mutations. International Journal of Cancer. https://doi.org/10.1002/ijc.2910640608
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
