Invasive Fusobacterium nucleatum may play a role in the carcinogenesis of proximal colon cancer through the serrated neoplasia pathway
Open accessAbstract
The prevalence of invasive Fusobacterium nucleatum ( Fn ) within the serrated neoplasia pathway of the proximal colon has seldom been investigated. We examined the invasive Fn and bacterial biofilms in 35 proximal hyperplastic polyps (HPs), 33 sessile serrated adenomas (SSAs), 48 proximal colorectal cancers (CRCs) and 10 matched metastatic lymph nodes using 16S rRNA fluorescence in situ hybridization (FISH). Samples of normal mucosa, traditional adenomas (TAs), distal HPs, distal CRCs and matched lymph nodes with or without metastases were used as controls. The prevalence of invasive Fn within proximal HPs (65.7%) and SSAs (78.8%) were significantly higher than that of proximal TAs (28.9%) and distal TAs (24.4%; p < 0.05). Invasive Fn was detected in markedly more proximal CRCs (89.6%) than in distal CRCs (42.2%; p < 0.05). Moreover, invasive Fn was detected in a significantly higher proportion of matched metastatic lymph nodes (100%) than that within nonmetastatic lymph nodes (40.0%; p < 0.001). Bacterial biofilms were found on 52.1% of proximal CRCs, 55.6% of distal CRCs and 48.5% of SSAs. Biofilms were positive for Fn in 47.9% of proximal CRCs, 48.9% of distal CRCs and 27.3% of SSAs. However, the presence of Fn in biofilms was not related to invasive Fn within colorectal tissues ( p = 0.415). Invasive Fn may play a role in the carcinogenesis of proximal colon developing via the serrated neoplasia pathway, but might have a less important role in the TA‐carcinoma sequence. Bacterial biofilms may not contribute to the invasion of Fn into tumor tissues.
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In colorectal cancer patients, microbiota composition is one factor favoring carcinogenic lesions, notably through genotoxic bacteria such as Fusobacterium nucleatum or colibactin-producing Escherichia coli.
“In CRC patients, it is known that the composition of the microbiota is one of the factors favoring the development of carcinogenic lesions, notably by the presence of genotoxic bacteria such as Fusobacterium nucleatum or colibactin-producing Escherichia coli (124, 125).”
From Bifidobacteria and Their Health-Promoting Effects (2017) · cites this paper as [125]
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References 42 · Cited by 176
Research works printed but not linked: 2
- V C 2016 UICC 10970215, 2016, 6, Downloaded from https://onlinelibrary.wiley.com/doi/10.1002/ijc.30168 by Readcube (Labtiva Inc.), Wiley Online Library on [15/08/2023]. See the Terms and Conditions (https://onlinelibrary.wiley.com/terms-and-conditions) on Wiley Online Library for rules of use; OA articles are governed by the applicable Creative Commons License · DOI
- Grady WM. CIMP and colon cancer gets more complicated. Gut 2007; 56:1498-1500.
- Authors
- Yu, J., Chen, Y., Fu, X., Zhou, X., Peng, Y., Shi, L., Chen, T., & Wu, Y.
- Affiliations
- Southwest Medical University (CN)
- Corresponding author
- Fu, Xiangsheng
- Venue
- International Journal of Cancer
- Publisher
- Wiley
- Published
- 2016-05-17
- Volume
- 139
- Issue
- 6
- Pages
- 1318-1326
- ISSN
- 0020-7136 (ISSN-L)
- 1097-0215
- OpenAlex
- W2343767836
- Cited by
- 176
- References
- 42
- Citations by year
- 2026: 7 · 2025: 18 · 2024: 24 · 2023: 18 · 2022: 21 · 2021: 18 · 2020: 18 · 2019: 20 · 2018: 19 · 2017: 13
- FWCI
- 9.01
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- International Journal of Cancer (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Health Sciences › Dentistry › Periodontics › Oral microbiology and periodontitis research
- Health Sciences › Medicine › Oncology › Colorectal Cancer Screening and Detection
- Keywords
- Fusobacterium nucleatum, serrated neoplasia pathway, right-sided colon cancer, colorectal cancer, sessile serrated adenoma, hyperplastic polyps, bacterial biofilms, colorectal carcinogenesis, metastatic lymph nodes, tumor invasion
- MeSH terms
- Adult, Aged, Aged, 80 and over, Cell Transformation, Neoplastic, Colonic Neoplasms, Female, Fusobacterium Infections, Humans, Male, Middle Aged, Neoplasm Staging, Signal Transduction, Fusobacterium nucleatum, Neoplasm Grading
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