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Cited by 69COVID-19 Impact on ReproductionCOVID-19 Clinical Research StudiesCardiovascular Issues in Pregnancy

The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.

Maternal death related to COVID‐19: A systematic review and meta‐analysis focused on maternal co‐morbidities and clinical characteristics

Open access
La Verde, Marco, Riemma, Gaetano, Torella, Marco, Cianci, Stefano, Savoia, Fabiana, Licciardi, Federico, Scida, Serena, Morlando, Maddalena, Colacurci, Nicola, De Franciscis, Pasquale·2021·International Journal of Gynecology & Obstetrics
DOI 10.1002/ijgo.13726PMC PMC9087672
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Abstract

Background: Besides reducing the quality of obstetric care, the direct impact of COVID‐19 on pregnancy and postpartum is uncertain. Objective: To evaluate the characteristics of pregnant women who died due to COVID‐19. Search strategy: Cochrane Library, Embase, MEDLINE, Scopus, and Google Scholar were searched from inception to February 2021. Selection criteria: Studies that compared deceased and survived pregnant women with COVID‐19. Data collection and analysis: Relevant data were extracted and tabulated. The primary outcome was maternal co‐morbidity. Main results: Thirteen studies with 154 deceased patients were included. Obesity doubled the risk of death (relative risk [RR] 2.48, 95% confidence interval [CI] 1.41–4.36, I2 = 0%). No differences were found for gestational diabetes (RR 5.71; 95% CI 0.77–42.44, I2 = 94%) or asthma (RR 2.05, 95% CI 0.81–5.15, I2 = 0%). Overall, at least one severe co‐morbidity showed a twofold increased risk of death (RR 2.26, 95% CI 1.77–2.89, I2 = 76%). Admission to intensive care was related to a fivefold increased risk of death (RR 5.09, 95% CI 2.00–12.98, I2 = 56%), with no difference in need for respiratory support (RR 0.53, 95% CI 0.23–1.48, I2 = 95%) or mechanical ventilation (RR 4.34, 95% CI 0.96–19.60, I2 = 58%). Conclusion: COVID‐19 with at least one co‐morbidity increases risk of intensive care and mortality.

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  • Maternal obesity was a factor in the deaths of women infected with COVID-19 during pregnancy, with more than double the risk of death in women with BMI greater than 30 kg/m2.

    “Maternal obesity was also a factor in the deaths of women who were infected with COVID‐19 during pregnancy, with more than double the risk of death in women with BMI > 30 kg m–2. 50”

    From Overweight, obesity and excessive weight gain in pregnancy as risk factors for adverse pregnancy outcomes: A narrative review (2022) · cites this paper as [50]

    The Results (Meta-analysis; page unavailable) report that maternal obesity was associated with a 2.48-fold risk of death during COVID-19 infection, supporting the more-than-double-risk claim. Our copy does not specify BMI >30 kg/m² as the obesity cutoff, so it does not establish the claim for that precise group. (LLM, conf=0.85)

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Metadata

Authors
La Verde, M., Riemma, G., Torella, M., Cianci, S., Savoia, F., Licciardi, F., Scida, S., Morlando, M., Colacurci, N., & De Franciscis, P.
Affiliations
  • Department of Woman, Child and General and Specialized Surgery, Obstetrics and Gynecology Unit University of Campania “Luigi Vanvitelli” Naples Italy
  • University of Campania "Luigi Vanvitelli" (IT)
  • University of Messina (IT)
Corresponding author
Riemma, Gaetano
ORCID
Venue
International Journal of Gynecology & Obstetrics
Publisher
Wiley
Published
2021-05-18
Volume
154
Issue
2
Pages
212-219
ISSN
  • 0020-6695 (ISSN-L)
  • 0020-7292
  • 1879-3479
DOI
10.1002/ijgo.13726
PMC
PMC9087672
OpenAlex
W3158859529
Cited by
69
References
2
Citations by year
2026: 2 · 2025: 7 · 2024: 12 · 2023: 16 · 2022: 24 · 2021: 8
FWCI
2.77
Type
journal article
Language
en
Open access
Licence
Locations
  • International Journal of Gynecology & Obstetrics (publishedVersion, cc-by-nc-nd)
  • PubMed Central (publishedVersion, cc-by-nc-nd)
  • PubMed (publishedVersion)
  • Archivio Istituzionale della Ricerca - Università degli Studi della Campania "Luigi Vanvitelli" (submittedVersion)
Topics
  • Health Sciences › Medicine › Obstetrics and Gynecology › COVID-19 Impact on Reproduction
  • Health Sciences › Medicine › Infectious Diseases › COVID-19 Clinical Research Studies
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Issues in Pregnancy
Keywords
COVID-19 pandemic, maternal mortality, pregnancy, maternal comorbidities, obesity, gestational diabetes mellitus, asthma, intensive care unit admission, mechanical ventilation, respiratory support, mortality risk factors
MeSH terms
COVID-19, SARS-CoV-2, Asthma, Female, Humans, Infant, Newborn, Maternal Mortality, Obesity, Pregnancy, Pregnancy Complications, Infectious, Comorbidity, Diabetes, Gestational, Postpartum Period, Pandemics, Maternal Death

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