Hypoglycemia during the oral glucose tolerance test in pregnancy-maternal characteristics and neonatal outcomes
Abstract
Objective To evaluate maternal and neonatal outcomes in pregnancies complicated by hypoglycemia on 100-g oral glucose tolerance test (OGTT). Methods A retrospective cohort analysis of all live-born deliveries in a single medical center during 2018 and 2019 with available OGTT results and birth outcomes. Preterm deliveries ( Results Overall, 2079 women were entered into the analysis. Of these, 216 (10.4%) had at least one hypoglycemic value, 1072 (51.6%) had normal OGTTs and 791 (38%) abnormal OGTTs. Hypoglycemia in OGTT was more prevalent in multiparous women and was associated with fetal male gender. Absolute birth weight, low birth weight and small for gestational age differed between groups; however, there was no difference between groups in overall birth weight centiles (60.1 ± 26.8 versus 63 ± 26 versus 60.9 ± 27; P > 0.05). Following adjustment of confounders, hypoglycemia was not associated with rates of low birth weight or small for gestational age (P Conclusion Hypoglycemia in OGTT is not associated with maternal or neonatal adverse outcomes.
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Short-term outcomes of reactive hypoglycemia range between no adverse maternal or neonatal outcome to association with low APGAR scores, lower birth weight, small head circumference and short body length, and perinatal admission to the NICU.
“Short term outcome of reactive hypoglycemia have been described, ranging between no adverse maternal or neonatal outcome to association with low APGAR scores, lower birth weight, small head circumference and short body length, and perinatal admission to the NICU [5,6].”
From Hypoglycemia in Oral Glucose Tolerance Test during Pregnancy and Risk for Type 2 Diabetes—A Five-Year Cohort Study (2024) · cites this paper as [5]
The prevalence of hypoglycemia during oGTT in pregnancy ranges between 3.6% and 11.3% in different reports.
“Accordingly, the prevalence of hypoglycemia during oGTT in pregnancy ranges between 3.6% and 11.3% in different reports [4,5,6,7].”
From Hypoglycemia in Oral Glucose Tolerance Test during Pregnancy and Risk for Type 2 Diabetes—A Five-Year Cohort Study (2024) · cites this paper as [5]
Previous studies investigating the association between reactive hypoglycemia and pregnancy outcomes have conflicting results.
“Previous studies investigated the association between reactive hypoglycemia and pregnancy outcomes with conflicting results [4,5,6,7].”
From Hypoglycemia in Oral Glucose Tolerance Test during Pregnancy and Risk for Type 2 Diabetes—A Five-Year Cohort Study (2024) · cites this paper as [5]
Cites
Criteria for screening tests for gestational diabetes
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ACOG Practice Bulletin No. 190: Gestational Diabetes Mellitus
(2018) · Obstetrics & Gynecology · doi:10.1097/aog.0000000000002501 · Cited by 1,820 · see citing works
U.S. Preventive Services Task Force* (2008) · Annals of Internal Medicine · doi:10.7326/0003-4819-148-10-200805200-00008 · Cited by 291 · see citing works
Moyer, V. A., & on behalf of the U.S. Preventive Services Task Force* (2014) · Annals of Internal Medicine · doi:10.7326/m13-2905 · Cited by 223 · see citing works
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Haggiag, N., Rotman, M., Hallak, M., Toledano, Y., Gabbay-Benziv, R., & Maor-Sagie, E. (2024) · Journal of Clinical Medicine · doi:10.3390/jcm13133806 · Cited by 4 · see citing works
“Reactive hypoglycemia is more prevalent in male fetuses, and younger and multiparous women [4,5].”
BackgroundSelf-citation
- Authors
- Raviv, S., Wilkof‐Segev, R., Maor‐Sagie, E., Naeh, A., Yoeli, Y., Hallak, M., & Gabbay‐Benziv, R.
- Affiliations
- Technion – Israel Institute of Technology (IL)
- Corresponding author
- Gabbay‐Benziv, Rinat
- Venue
- International Journal of Gynecology & Obstetrics
- Publisher
- Wiley
- Published
- 2021-12-05
- Volume
- 158
- Issue
- 3
- Pages
- 585-591
- ISSN
- 0020-6695 (ISSN-L)
- 0020-7292
- 1879-3479
- OpenAlex
- W3212723779
- Cited by
- 15
- References
- 4
- Citations by year
- 2026: 1 · 2025: 9 · 2024: 2 · 2023: 2 · 2022: 1
- FWCI
- 1.13
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- International Journal of Gynecology & Obstetrics (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Obstetrics and Gynecology › Gestational Diabetes Research and Management
- Health Sciences › Medicine › Obstetrics and Gynecology › Maternal and Perinatal Health Interventions
- Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Birth, Development, and Health
- Keywords
- hypoglycemia, oral glucose tolerance test, pregnancy, maternal characteristics, neonatal outcomes, low birth weight, small for gestational age, birth weight, multiparity, fetal sex, perinatal outcomes
- MeSH terms
- Birth Weight, Blood Glucose, Female, Fetal Growth Retardation, Glucose Tolerance Test, Humans, Hypoglycemia, Infant, Newborn, Infant, Newborn, Diseases, Male, Pregnancy, Pregnancy Outcome, Retrospective Studies, Diabetes, Gestational
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