Cross-talk between bile acids and gastrointestinal tract for progression and development of cancer and its therapeutic implications
Open accessAbstract
Increasing incidences of gastrointestinal (GI) cancer are linked to changes in lifestyle with excess of red meat/fat consumption, and elevated secretion of bile acids. Bile acids are strong signaling molecules that control various physiological processes. Failure in bile acid regulation has detrimental effects, often linked with development and promotion of cancer of digestive tract including esophagus, stomach, liver, and intestine. Excessive concentration of bile acids especially lipophillic secondary bile acids are cytotoxic causing apoptosis and reactive oxygen species-mediated damage to the cells. Resistance to this apoptosis and accumulation of mutations leads to progression of cancer. Cytotoxicity of bile acids is contingent on their chemical structure. In this review, we discuss the chemistry of bile acids, bile acid mediated cellular signaling processes, their role in GI cancer progression, and therapeutic potential of synthetic bile acid derivatives for cancer therapy.
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Excessive bile acid accumulation can lead to colon cancer development.
“Furthermore, excessive bile acid accumulation can lead to colon cancer development [104].”
From Current Concepts in Probiotic Safety and Efficacy (2026) · cites this paper as [104]
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References 70 · Cited by 56
Research works printed but not linked: 1
- Singh, M., Bansal, S., Kundu, S., Bhargava, P., Singh, A., et al. (2015) Syn- thesis, structure-activity relationship, and mechanistic investigation of litho- cholic acid amphiphiles for colon cancer therapy. Med. Chem. Commun. 6, 192-201.
- Authors
- Kundu, S., Kumar, S., & Bajaj, A.
- Affiliations
- Manipal Academy of Higher Education (IN)
- Regional Centre for Biotechnology (IN)
- Corresponding author
- Bajaj, Avinash
- Venue
- IUBMB Life
- Publisher
- Wiley
- Published
- 2015-07
- Volume
- 67
- Issue
- 7
- Pages
- 514-523
- ISSN
- 1521-6543 (ISSN-L)
- 1521-6551
- OpenAlex
- W1646057852
- Cited by
- 56
- References
- 70
- Citations by year
- 2026: 2 · 2025: 3 · 2024: 7 · 2023: 2 · 2022: 12 · 2021: 7 · 2020: 6 · 2019: 4 · 2018: 4 · 2017: 7 · 2016: 2
- FWCI
- 0.47
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- IUBMB Life (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Regional Centre for Biotechnology and Department of Biotechnology
- Topics
- Health Sciences › Medicine › Oncology › Drug Transport and Resistance Mechanisms
- Health Sciences › Medicine › Surgery › Cholangiocarcinoma and Gallbladder Cancer Studies
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Cancer, Lipids, and Metabolism
- Keywords
- bile acids, gastrointestinal cancer, secondary bile acids, bile acid signaling, apoptosis, reactive oxygen species, tumor progression, cancer therapy, red meat consumption
- MeSH terms
- Bile Acids and Salts, Biological Transport, Gastrointestinal Neoplasms, Humans, Signal Transduction, Apoptosis, Receptors, Cytoplasmic and Nuclear, Gastrointestinal Tract
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