Small‐molecule protein–protein interaction inhibitors: Therapeutic potential in light of molecular size, chemical space, and ligand binding efficiency considerations

Buchwald, Peter·2010·IUBMB Life

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    Christos Ap. LADIAS, Pavlos Papakotoulas, Maria Papaioannou, Nikolaos A. Papanikolaou · 2023 · Exploration of Targeted Anti-tumor Therapy
  20. Overview of Protein-Protein Interactions and Small-Molecule Inhibitors Under Clinical Development
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  24. Design of peptide and small molecule inhibitors of cyclin dependent kinase 9/cyclin T1 protein-protein interaction using computational methods
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  27. Targeting the menin-MLL-LEDGF Interaction with Small Molecule Inhibitors.
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  34. BindingDB Entry 50002244: Complexity of Blocking Bivalent Protein-Protein Interactions: Development of a Highly Potent Inhibitor of the Menin-Mixed-Lineage Leukemia Interaction.
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  35. BindingDB Entry 50044412: Design, synthesis and in vitro and in vivo antitumour activity of 3-benzylideneindolin-2-one derivatives, a novel class of small-molecule inhibitors of the MDM2-p53 interaction.
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  39. BindingDB Entry 50047242: Property Focused Structure-Based Optimization of Small Molecule Inhibitors of the Protein-Protein Interaction between Menin and Mixed Lineage Leukemia (MLL).
    BindingDB · 2017 · UC San Diego
  40. BindingDB Entry 50006029: High-affinity small-molecule inhibitors of the menin-mixed lineage leukemia (MLL) interaction closely mimic a natural protein-protein interaction.
    BindingDB · 2020 · UC San Diego