Cited by 2,458Protein Structure and DynamicsEnzyme Structure and FunctionRNA and protein synthesis mechanisms

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The relation between the divergence of sequence and structure in proteins.

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Chothia, C., Lesk, A.M.·1986·The EMBO Journal

DOI 10.1002/j.1460-2075.1986.tb04288.xPMC PMC1166865

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Abstract

Homologous proteins have regions which retain the same general fold and regions where the folds differ. For pairs of distantly related proteins (residue identity approximately 20%), the regions with the same fold may comprise less than half of each molecule. The regions with the same general fold differ in structure by amounts that increase as the amino acid sequences diverge. The root mean square deviation in the positions of the main chain atoms, delta, is related to the fraction of mutated residues, H, by the expression: delta(A) = 0.40 e1.87H.

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Authors: Chothia, C., & Lesk, A. M.
ORCID: Lesk, A.M.
Venue: The EMBO Journal
Publisher: Springer Science and Business Media LLC
Published: 1986-04-01
Volume: 5
Issue: 4
Pages: 823-826
ISSN: 0261-4189 (ISSN-L)
1460-2075
DOI: 10.1002/j.1460-2075.1986.tb04288.x
PMC: PMC1166865
OpenAlex: W1508885706
Cited by: 2,458
References: 28
Citations by year: 2026: 61 · 2025: 56 · 2024: 44 · 2023: 66 · 2022: 62 · 2021: 52 · 2020: 56 · 2019: 59 · 2018: 74 · 2017: 67 · 2016: 64 · 2015: 67 · 2014: 67 · 2013: 100 · 2012: 96
FWCI: 8.63
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: www.springer.com/tdm (tdm)
www.springer.com/tdm (vor)
Locations: The EMBO Journal (publishedVersion)
Europe PMC (PubMed Central) (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Funders: National Institute of General Medical Sciences (GM25435)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Protein Structure and Dynamics
Life Sciences › Biochemistry, Genetics and Molecular Biology › Structural Biology › Enzyme Structure and Function
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › RNA and protein synthesis mechanisms
Keywords: sequence-structure relationship, protein folding, homologous proteins, sequence divergence, structural divergence, RMSD, main-chain conformation, distant homologs
MeSH terms: Amino Acid Sequence, Animals, Humans, Mutation, Protein Conformation, Proteins, Structure-Activity Relationship

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The relation between the divergence of sequence and structure in proteins.

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