The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
An efficient ribosomal frame-shifting signal in the polymerase-encoding region of the coronavirus IBV.
Open accessAbstract
The polymerase‐encoding region of the genomic RNA of the coronavirus infectious bronchitis virus (IBV) contains two very large, briefly overlapping open reading frames (ORF), F1 and F2, and it has been suggested on the basis of sequence analysis that expression of the downstream ORF, F2, might be mediated through ribosomal frame‐shifting. To examine this possibility a cDNA fragment containing the F1/F2 overlap region was cloned within a marker gene and placed under the control of the bacteriophage SP6 promoter in a recombinant plasmid. Messenger RNA transcribed from this plasmid, when translated in cell‐free systems, specified the synthesis of polypeptides whose size was entirely consistent with the products predicted by an efficient ribosomal frame‐shifting event within the overlap region. The nature of the products was confirmed by their reactivity with antisera raised against defined portions of the flanking marker gene. This is the first non‐retroviral example of ribosomal frame‐shifting in higher eukaryotes.
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Cites
Moore, R., Dixon, M., Smith, R., Peters, G., & Dickson, C. (1987) · Journal of Virology · doi:10.1128/jvi.61.2.480-490.1987 · Cited by 256
Cited by
The Molecular Biology of Coronaviruses
Masters, P. S. (2006) · Advances in Virus Research · doi:10.1016/s0065-3527(06)66005-3 · Cited by 1,761
Minskaia, E., Hertzig, T., Gorbalenya, A. E., Campanacci, V., Cambillau, C., Canard, B., & Ziebuhr, J. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0508200103 · Cited by 624
Vijgen, L., Keyaerts, E., Moës, E., Thoelen, I., Wollants, E., Lemey, P., Vandamme, A.-M., & Van Ranst, M. (2005) · Journal of Virology · doi:10.1128/jvi.79.3.1595-1604.2005 · Cited by 594
Varmus, H. (1988) · Science · doi:10.1126/science.3287617 · Cited by 523
Programmed translational frameshifting
Farabaugh, P. J. (1996) · Microbiological Reviews · doi:10.1128/mr.60.1.103-134.1996 · Cited by 316
Metadata
- Authors
- Brierley, I., Boursnell, M. E., Binns, M. M., Bilimoria, B., Blok, V. C., Brown, T. D., & Inglis, S. C.
- Venue
- The EMBO Journal
- Published
- 1987-12
- Volume
- 6
- Issue
- 12
- Pages
- 3779-3785
- ISSN
- 0261-4189 (ISSN-L)
- OpenAlex
- W184913305
- Cited by
- 314
- References
- 1
- FWCI
- 6.21
- Type
- journal article
- Language
- en
- Open access
- bronze
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- The paper
- Brierley, I., Boursnell, M. E., Binns, M. M., Bilimoria, B., Blok, V. C., Brown, T. D., & Inglis, S. C. (1987). An efficient ribosomal frame-shifting signal in the polymerase-encoding region of the coronavirus IBV. The EMBO Journal. https://doi.org/10.1002/j.1460-2075.1987.tb02713.x
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
