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Head and tail development of the Drosophila embryo involves spalt, a novel homeotic gene
Open accessAbstract
Mutations in spalt (sal), a novel homeotic gene on the second chromosome of Drosophila, cause opposite transformations in two subterminal regions of the embryo: posterior head segments are transformed into anterior thoracic structures and anterior tail segments are transformed into posterior abdominal structures. The embryonic phenotypes of double mutants for sal and various Antennapedia (ANT-C) or bithorax (BX-C) genes indicate that sal acts independently of the hierarchical order of the latter gene complexes. Trans-regulatory gene mutations causing ectopic expression of ANT-C and BX-C genes do not change the realms of sal action. It is proposed that the region-specific action of the sal gene primarily promotes head as opposed to trunk development, while the BX-C gene AbdB distinguishes tail from head.
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“Spalt-like (SALL) proteins are C2H2 zinc-finger transcription factors important for embryogenesis”
From Tetramerisation governs SALL transcription factor function in development and disease (2025) · cites this paper as [1]
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- Hayes,P.H., Sato,T. and Denell,R.E. (1984) Proc. Natl. Acad. Sci. USA., 81, 545-549.
- Alan R.Liss, New York, pp. 365-383.
- Kaufman,T.C. and Abbott,M.K. (1984) Molecular Aspects ofEarly Develop- ment. Plenum Press, New York, pp. 189-218.
- Struhl,G. (1982) Proc. Natl. Acad. Sci. USA., 79, 7380-7384.
- Wirz,J., Fessler,L.I. and Gehring,W.J. (1986) EMBO J., 5, 3327-3334. Received on October 11, 1987 14602075, 1988, 1, Downloaded from https://www.embopress.org/doi/10.1002/j.1460-2075.1988.tb02799.x by Readcube (Labtiva Inc.), Wiley Online Library on [01/09/2023]. See the Terms and Conditions (https://onlinelibrary.wiley.com/terms-and-conditions) on Wiley Online Library for rules of use; OA articles are governed by the applicable Creative Commons License · DOI
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Casanova, J. (1989) · Roux's archives of developmental biology · doi:10.1007/bf02438938 · Cited by 4
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Medina-Jiménez, B. I., Budd, G., & Janssen, R. (2021) · EvoDevo · doi:10.1186/s13227-021-00177-y · Cited by 3
“Two other genes that are involved in the determination of body regions in Drosophila are the homeodomain encoding gene teashirt (tsh) [18], and the zinc finger encoding gene spalt (sal) [20, 38].”
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Heads or tails? A homeotic gene for both.
Sánchez-Herrero, E. (1988) · Trends in Genetics · doi:10.1016/0168-9525(88)90130-8 · Cited by 2
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Yip, M. L. R., & Lipshitz, H. D. (1996) · Advances in developmental biology · doi:10.1016/s1566-3116(08)60017-1 · Cited by 1
Tetramerisation governs SALL transcription factor function in development and disease
Giuliani, S., Chhatbar, K., Wear, M., Guy, J., Mathieson, T., Burdett, H., George, L., Alston, G., Spanos, C., McHugh, T., et al. (2025) · bioRxiv · doi:10.1101/2025.10.27.684836
Parker, G., & Roberts, D. B. (1996) · Biochemical Genetics · doi:10.1007/bf02396245
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Tsonis, P., & Goetinck, P. (1988) · doi:10.1016/s0174-173x(88)80018-9
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Metadata
- Authors
- Jürgens, G.
- Affiliations
- Max Planck Institute for Developmental Biology (DE)
- Corresponding author
- Jürgens, Gerd
- ORCID
- Jürgens, Gerd
- Venue
- The EMBO Journal
- Published
- 1988-01-01
- Volume
- 7
- Issue
- 1
- Pages
- 189-196
- ISSN
- 0261-4189 (ISSN-L)
- 1460-2075
- PMC
- PMC454247
- OpenAlex
- W89847511
- Cited by
- 145
- References
- 0
- Citations by year
- 2025: 1 · 2022: 1 · 2021: 5 · 2019: 2 · 2018: 3 · 2017: 4 · 2016: 3 · 2015: 2 · 2014: 5 · 2013: 7 · 2012: 7
- FWCI
- 2.51
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- The EMBO Journal (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Developmental Biology and Gene Regulation
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Genomics and Chromatin Dynamics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurobiology and Insect Physiology Research
- Keywords
- spalt, homeotic genes, Drosophila embryo, head development, tail development, Antennapedia complex, bithorax complex, Abdominal-B, ectopic expression
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